Browsing by Author "Doolaanea, Abd Almonem"
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3D culture of cancer cells in alginate hydrogel beads as an effective technique for emergency cell storage and transportation in the pandemic era
Alallam, Batoul; May, Kyaw Oo; Ibrahim, Wisam Nabeel; Doolaanea, Abd Almonem ( Wiley , 2021 , Article)Due to the restrictions in access to research lab during the pandemic time and due to existence of challenges in providing proper storage and transportation of cells in developing countries, having an effective and feasible ... -
Characterization of neurobehavioral pattern in a zebrafish 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced model: A 96-hour behavioral study
Razali, Khairiah; Mohd Nasir, Mohd Hamzah; Othman, Noratikah; Doolaanea, Abd Almonem; Kumar, Jaya; Nabeel Ibrahim, Wisam; Mohamed, Wael M. Y.... more authors ... less authors ( Public Library of Science , 2022 , Article)Parkinson’s disease (PD) is the most common brain motor disorder, characterized by a substantial loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc). Motor impairments, such as dyskinesia, bradykinesia, ... -
Curcumin gum Arabic nanoparticles demonstrate potent antioxidant and cytotoxic properties in human cancer cells
Hassani, Abdelkader; Hussain, Siti Aslina; Al-Qubaisi, Mothanna Sadiq; Belfar, Mohamed Lakhder; Belkhalfa, Hakim; Enezei, Hamid Hammad; Zentou, Hamid; Ibrahim, Wisam Nabeel; Doolaanea, Abd Almonem... more authors ... less authors ( Tech Science Press , 2022 , Article)The main purpose of the study was to enhance the stability and therapeutic effects of Curcumin (Cur) through nanoformulation with gum Arabic (GA) as a coating agent through an efficient synthetic approach. The antioxidant ... -
Formulation, Cellular Uptake and Cytotoxicity of Thymoquinone-Loaded PLGA Nanoparticles in Malignant Melanoma Cancer Cells
Ibrahim, Wisam Nabeel; Bin Mohd Rosli, Luqman Muizzuddin; Doolaanea, Abd Almonem ( Dove Medical Press , 2020 , Article)Introduction: Thymoquinone (TQ) is the main active compound extracted from Nigella sativa a traditional herb with wide therapeutic applications and recognizable anticancer properties. This study aimed to formulate and ... -
Formulation, Characterization and Biological Activity Screening of Sodium Alginate-Gum Arabic Nanoparticles Loaded with Curcumin.
Hassani, Abdelkader; Mahmood, Syed; Enezei, Hamid Hammad; Hussain, Siti Aslina; Hamad, Hamad Ali; Aldoghachi, Ahmed Faris; Hagar, Abdullah; Doolaanea, Abd Almonem; Ibrahim, Wisam Nabeel... more authors ... less authors ( MDPI , 2020 , Article)The approach of drug delivery systems emphasizes the use of nanoparticles as a vehicle, offering the optional property of delivering drugs as a single dose rather than in multiple doses. The current study aims to improve ... -
The Promise of the Zebrafish Model for Parkinson’s Disease: Today’s Science and Tomorrow’s Treatment
Razali, Khairiah; Othman, Noratikah; Mohd Nasir, Mohd Hamzah; Doolaanea, Abd Almonem; Kumar, Jaya; Ibrahim, Wisam Nabeel; Ibrahim, Norlinah Mohamed; Mohamed, Wael M. Y.... more authors ... less authors ( Frontiers Media , 2021 , Article)The second most prevalent neurodegenerative disorder in the elderly is Parkinson’s disease (PD). Its etiology is unclear and there are no available disease-modifying medicines. Therefore, more evidence is required concerning ... -
Thymoquinone Suppresses Cell Proliferation and Enhances Apoptosis of HL60 Leukemia Cells through Re-Expression of JAK/STAT Negative Regulators.
Almajali, Belal; Al-Jamal, Hamid Ali Nagi; Wan Taib, Wan Rohani; Ismail, Imilia; Johan, Muhammad Farid; Doolaanea, Abd Almonem; Ibrahim, Wisam Nabeel; Tajudin, Syed Ahmad... more authors ... less authors ( West Asia Organization for Cancer Prevention (WAOCP) , 2021 , Article)The natural compound, thymoquinone (TQ) has demonstrated potential anticancer properties in inhibiting cell proliferation and promoting apoptosis in myeloid leukemia cells, breast cancer cells, and others. However, the ... -
Thymoquinone, as a Novel Therapeutic Candidate of Cancers
Almajali, Belal; Nagi, Hamid Ali; Taib, Wan Rohani Wan; Ismail, Imilia Ismail; Johan, Muhammad Farid; Doolaanea, Abd Almonem; Ibrahim, Wisam Nabeel... more authors ... less authors ( MDPI , 2021 , Article)To date, natural products are widely used as pharmaceutical agents for many human diseases and cancers. One of the most popular natural products that have been studied for anticancer properties is thymoquinone (TQ). As ...