Browsing by Author "Karim, Nagi"
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Biased agonism at G protein-coupled receptors
Karim, Nagi; Onaran, H. Ongun ( Elsevier , 2021 , Other)G protein-coupled receptors (GPCRs) represent the largest family of approved therapeutic targets. Ligands stimulating these receptors specifically activate multiple signalling pathways that induce not only the desired ... -
Biased signaling: A viable strategy to drug ghrelin receptors for the treatment of obesity
Karim, Nagi; Habib, Abdella M. ( Elsevier , 2021 , Article)Obesity is a global burden and a chronic ailment with damaging overall health effects. Ghrelin, an octanoylated 28 amino acid peptide hormone, is secreted from the oxyntic mucosa of the stomach. Ghrelin acts on regions of ... -
In-frame fusion of SUMO1 enhances βarrestin2's association with activated GPCRs as well as with nuclear pore complexes
Karim, Nagi; Kaur, Suneet; Bai, Yushi; Shenoy, Sudha K. ( Elsevier , 2020 , Article)Small ubiquitin like modifier (SUMO) conjugation or SUMOylation of βarrestin2 promotes its association with the clathrin adaptor protein AP2 and facilitates rapid β2 adrenergic receptor (β2AR) internalization. However, ...