تصفح حسب المؤلف "El-Agnaf, Omar M."
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Blood Proteomics Analysis Reveals Potential Biomarkers and Convergent Dysregulated Pathways in Autism Spectrum Disorder: A Pilot Study
Mesleh, Areej; Ehtewish, Hanan; de la Fuente, Alberto; Al-shamari, Hawra; Ghazal, Iman; Al-Faraj, Fatema; Al-Shaban, Fouad; Abdesselem, Houari B.; Emara, Mohamed; Alajez, Nehad M.; Arredouani, Abdelilah; Decock, Julie; Albagha, Omar; Stanton, Lawrence W.; Abdulla, Sara A.; El-Agnaf, Omar M.A.... more authors ... less authors ( Multidisciplinary Digital Publishing Institute (MDPI) , 2023 , Article)Autism spectrum disorder (ASD) is an umbrella term that encompasses several disabling neurodevelopmental conditions. These conditions are characterized by impaired manifestation in social and communication skills with ... -
Cerebrospinal fluid α-synuclein species in cognitive and movements disorders
Constantinides, Vasilios C.; Majbour, Nour K.; Paraskevas, George P.; Abdi, Ilham; Safieh-Garabedian, Bared; Stefanis, Leonidas; El-Agnaf, Omar M.; Kapaki, Elisabeth... more authors ... less authors ( Multidisciplinary Digital Publishing Institute (MDPI) , 2021 , Article)Total CSF α-synuclein (t-α-syn), phosphorylated α-syn (pS129-α-syn) and α-syn oligomers (o-α-syn) have been studied as candidate biomarkers for synucleinopathies, with suboptimal specificity and sensitivity in the ... -
Novel engineered nanobodies specific for N-terminal region of alpha-synuclein recognize Lewy-body pathology and inhibit in-vitro seeded aggregation and toxicity.
Hmila, Issam; Vaikath, Nishant N; Majbour, Nour K; Erskine, Daniel; Sudhakaran, Indulekha P; Gupta, Vijay; Ghanem, Simona S; Islam, Zeyaul; Emara, Mohamed M; Abdesselem, Houari B; Kolatkar, Prasanna R; Achappa, Devaya K; Vinardell, Tatiana; El-Agnaf, Omar M A... more authors ... less authors ( FEBS PRESS , 2022 , Article)Nanobodies (Nbs), the single-domain antigen-binding fragments of dromedary heavy-chain antibodies (HCAb), are excellent candidates as therapeutic and diagnostic tools in synucleinopathies because of their small size, ...