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    Browsing by Author "Kontogianni, Iris"

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        Divergent Biochemical Properties and Disparate Impact of Arrhythmogenic Calmodulin Mutations on Zebrafish Cardiac Function 

        Da'as, Sahar I.; Thanassoulas, Angelos; Calver, Brian L.; Saleh, Alaaeldin; Abdelrahman, Doua; Hasan, Waseem; Safieh-Garabedian, Bared; Kontogianni, Iris; Nasrallah, Gheyath K.; Nounesis, George; Lai, F. Anthony; Nomikos, Michail... more authors ... less authors ( John Wiley & Sons , 2024 , Article)
        Calmodulin (CaM) is a ubiquitous, small cytosolic calcium (Ca2+)-binding sensor that plays a vital role in many cellular processes by binding and regulating the activity of over 300 protein targets. In cardiac muscle, CaM ...
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        Life-threatening arrhythmogenic CaM mutations disrupt CaM binding to a distinct RyR2 CaM-binding pocket 

        Angelos, Thanassoulas; Vassilakopoulou, Vyronia; Calver, Brian L.; Buntwal, Luke; Smith, Adrian; Lai, Christopher; Kontogianni, Iris; Livaniou, Evangelia; Nounesis, George; Lai, F. Anthony; Nomikos, Michail... more authors ... less authors ( Elsevier , 2023 , Article)
        Calmodulin (CaM) modulates the activity of several proteins that play a key role in excitation-contraction coupling (ECC). In cardiac muscle, the major binding partner of CaM is the type-2 ryanodine receptor (RyR2) and ...

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        Qatar University Digital Hub is a digital collection operated and maintained by the Qatar University Library and supported by the ITS department

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