Browsing by Author "Wood, John N."

Now showing items 1-3 of 3

    • Distinct transcriptional responses of mouse sensory neurons in models of human chronic pain conditions [version 1; referees: 2 approved] 

      BangaBangash M.A.; Alles, Sascha R. A.; Santana-Varela, Sonia; Millet, Queensta; Sikandar, Shafaq; ... more authors ( F1000 Research Ltd , 2018 , Article)
      Background: Sensory neurons play an essential role in almost all pain conditions, and have recently been classified into distinct subsets on the basis of their transcriptomes. Here we have analysed alterations in dorsal ...

    • Molecular basis of FAAH-OUT-associated human pain insensitivity. 

      Mikaeili, Hajar; Habib, Abdella M; Yeung, Charlix Wai-Lok; Santana-Varela, Sonia; Luiz, Ana P; ... more authors ( Oxford University Press , 2023 , Article)
      Chronic pain affects millions of people worldwide and new treatments are needed urgently. One way to identify novel analgesic strategies is to understand the biological dysfunctions that lead to human inherited pain ...

    • Pain-causing stinging nettle toxins target TMEM233 to modulate NaV1.7 function 

      Jami, Sina; Deuis, Jennifer R.; Klasfauseweh, Tabea; Cheng, Xiaoyang; Kurdyukov, Sergey; ... more authors ( Nature Research , 2023 , Article)
      Voltage-gated sodium (NaV) channels are critical regulators of neuronal excitability and are targeted by many toxins that directly interact with the pore-forming α subunit, typically via extracellular loops of the ...