Browsing by Author "Emara, Mohamed M."
Now showing items 1-20 of 33
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A meta-review of meta-analyses and an updated meta-analysis on the efficacy of chloroquine and hydroxychloroquine in treating COVID19 infection
( Qatar University Press , 2020 , Poster)Objective: To synthesize the findings presented in systematic reviews and meta-analyses as well as to update the evidence using a meta-analysis in evaluating the efficacy and safety of CQ and HCQ with or without Azithromycin ... -
Assessing the consistency of iPSC and animal models in cystic fibrosis modelling: A metaanalysis
( Public Library of Science , 2022 , Article)Introduction Cystic fibrosis (CF) is a hereditary autosomal recessive disorder caused by a range of mutations in the CF Transmembrane Conductance Regulator (CFTR) gene. This gene encodes the CFTR protein, which acts as a ... -
Association between Multimorbidity and COVID-19 Mortality in Qatar: A Cross-Sectional Study
( PagePress , 2023 , Article)This study assessed the association between multimorbidity and mortality from COVID-19 in the Middle East and North Africa region, where such data are scarce. We conducted a cross-sectional study using data of all cases ... -
Burden and disease pathogenesis of influenza and other respiratory viruses in diabetic patients
( Elsevier , 2022 , Article Review)Over the past two decades, diabetes mellitus (DM) has been receiving increasing attention among autoimmune diseases. The prevalence of type 1 and type 2 diabetes has increased rapidly and has become one of the leading ... -
CCN3, POSTN, and PTHLH as potential key regulators of genomic integrity and cellular survival in iPSCs
( Frontiers Media SA , 2024 , Article)Reprogramming human somatic cells into a pluripotent state, achieved through the activation of well-defined transcriptional factors known as OSKM factors, offers significant potential for regenerative medicine. While OSKM ... -
Combined Noncoding RNA-mRNA Regulomics Signature in Reprogramming and Pluripotency in iPSCs
( Multidisciplinary Digital Publishing Institute (MDPI) , 2022 , Article)Somatic cells are reprogrammed with reprogramming factors to generate induced pluripotent stem cells (iPSCs), offering a promising future for disease modeling and treatment by overcoming the limitations of embryonic stem ... -
COVID-19 exit strategy during vaccine implementation: a balance between social distancing and herd immunity
( Springer , 2022 , Article Review)Currently, health authorities around the world are struggling to limit the spread of COVID-19. Since the beginning of the pandemic, social distancing has been the most important strategy used by most countries to control ... -
Demographic and Clinical Characteristics of Early Travel-Associated COVID-19 Cases
( Frontiers Media , 2020 , Article)© Copyright © 2020 Marei, Emara, Elsaied, Nasrallah, Chivese, Al-Romaihi, Althani, Al Thani, Farag and Yassine. Background: SARS-CoV-2 continues to claim hundreds of thousands of people's lives. It mostly affects the elderly ... -
Efficacy of chloroquine and hydroxychloroquine in treating COVID-19 infection: A meta-review of systematic reviews and an updated meta-analysis
( Elsevier , 2021 , Article)To synthesize findings from systematic reviews and meta-analyses on the efficacy and safety of chloroquine (CQ) and hydroxychloroquine (HCQ) with or without Azithromycin for treating COVID-19, and to update the evidence ... -
Erratum: Assessing the consistency of iPSC and animal models in cystic fibrosis modelling: A meta-analysis. (PLoS ONE (2022) 17:8 (e0272091) DOI: 10.1371/journal.pone.0272091)
( Public Library of Science , 2024 , Article)There are errors in the Funding section. The correct Funding statement is: The author acknowledges Qatar National Library for funding the publication of the article. -
Fibrillar form of α-synuclein-specific scFv antibody inhibits α-synuclein seeds induced aggregation and toxicity
( Springer Nature , 2020 , Article)Synucleinopathies including Parkinson’s disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA) are characterized by pathological accumulation of α-synuclein (α-syn). Amongst the various approaches ... -
Generation of human-induced pluripotent stem cells from a patient with homozygous I1234V mutation of cystic fibrosis.
( Hamad bin Khalifa University Press , 2024 , Article)Cystic fibrosis (CF) is an inherited autosomal recessive disorder. The most predominant mutation among Qatari patients with CF is the homozygous I1234V mutation, which is more prevalent in a Bedouin tribe.1 There are no ... -
High-throughput autoantibody screening identifies differentially abundant autoantibodies in autism spectrum disorder
( Frontiers Media SA , 2023 , Article)Introduction: Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by defects in two core domains, social/communication skills and restricted/repetitive behaviors or interests. There is no approved ... -
Hyperosmotic Stress Induces a Specific Pattern for Stress Granule Formation in Human-Induced Pluripotent Stem Cells
( Hindawi , 2021 , Article)Stress granules (SGs) are assemblies of selective messenger RNAs (mRNAs), translation factors, and RNA-binding proteins in small untranslated messenger ribonucleoprotein (mRNP) complexes in the cytoplasm. Evidence indicates ... -
Identification of potential transcription factors that enhance human iPSC generation
( Springer Nature , 2020 , Article)Although many factors have been identified and used to enhance the iPSC reprogramming process, its efficiency remains quite low. In addition, reprogramming efficacy has been evidenced to be affected by disease mutations ... -
Identification of Prognostic Metabolomic Biomarkers at the Interface of Mortality and Morbidity in Pre-Existing TB Cases Infected With SARS-CoV-2
( Frontiers Media S.A. , 2022 , Article)Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection currently remains one of the biggest global challenges that can lead to acute respiratory distress syndrome (CARDS) in severe cases. In line with this, ... -
Immune transcriptomic analysis on COVID-19 patients with varying clinical presentations identifies severity markers
( Nature Research , 2025 , Article)Coronavirus disease (COVID-19) is a heterogeneous infectious disease caused by the novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The distinctive features of COVID-19 infection encompass ... -
The impact of pre-existing immunity on the emergence of within-host immune-escape mutations in Omicron lineages
( Microbiology Society , 2025 , Article)The Omicron variant of SARS-CoV-2 circulating amongst highly immunized populations is anticipated to induce immunological pressures, potentially compromising existing immunity. This study investigates vaccine-induced ... -
Influenza prevalence and vaccine efficacy among diabetic patients in Qatar
( Elsevier , 2023 , Article)Seasonal influenza viruses may lead to severe illness and mortality in patients with comorbidities, including Diabetes Mellitus (DM). Vaccination against influenza in DM patients may reduce influenza incidence and severity. ... -
Inhibition of alpha-synuclein seeded fibril formation and toxicity by herbal medicinal extracts.
( BMC , 2020 , Article)Recent studies indicated that seeded fibril formation and toxicity of α-synuclein (α-syn) play a main role in the pathogenesis of certain diseases including Parkinson's disease (PD), multiple system atrophy, and dementia ...
