Browsing by Author "Buddenkotte, Joerg"
Now showing items 1-6 of 6
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Metabolomics analyses reveal the crucial role of ERK in regulating metabolic pathways associated with the proliferation of human cutaneous T-cell lymphoma cells treated with Glabridin
Khan, Abdul Q.; Agha, Maha Victor; Ahmad, Fareed; Anver, Rasheeda; Sheikhan, Khalid Sultan A.M.; Mateo, Jericha; Alam, Majid; Buddenkotte, Joerg; Uddin, Shahab; Steinhoff, Martin... more authors ... less authors ( John Wiley and Sons , 2024 , Article)Cutaneous T-cell lymphomas (CTC) are a heterogeneous group of T-cell lymphoproliferative malignancies of the skin with limited treatment options, increased resistance and remission. Metabolic reprogramming is vital in ... -
Neuronal BST2: A Pruritic Mediator alongside Protease-Activated Receptor 2 in the IL-27–Driven Itch Pathway
Yanqing, Li; Chen, Weiwei; Zhu, Xingyun; Mei, Huiyuan; Steinhoff, Martin; Buddenkotte, Joerg; Wang, Jinhai; Zhang, Wenhao; Li, Zhenghui; Dai, Xiaolong; Shan, Chunxu; Wang, Jiafu; Meng, Jianghui... more authors ... less authors ( Elsevier , 2024 , Article)Chronic itch is a common and complex symptom often associated with skin diseases such as atopic dermatitis (AD). Although IL-27 is linked to AD, its role and clinical significance in itch remain undefined. We sought to ... -
Retrospective evaluation of a TEN/SJS series managed with a new treatment protocol
Steinhoff, Martin; Buddenkotte, Joerg; Al-Shafi, Wadha; Al-Marri, Hissa; Emam, Fatima; Iqneibi, Mariam; Harris, Tim Richard Edmund; Thomas, Stephen H.; Asad, Syed Muhammad; Al-Maslamani, Hanan; Joy, Febu Elizabeth; Therachiyil, Lubna; Jochebeth, Anh; Leo, Rari; Younis, Shahad M.; Abu Raddad, Laith Jamal; Dargham, Soha Roger; Al-Khawaga, Sara... more authors ... less authors ( John Wiley and Sons , 2024 , Other)Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare, life-threatening diseases without standardized treatment. The mortality rate ranges from 20% to 50%, and can reach up to 90%, based on the ... -
Sanguinarine Triggers Apoptosis in Cutaneous Squamous Cell Carcinoma Cells through Reactive Oxygen Species-Dependent c-Jun N-Terminal Kinase Signaling Pathway
Patil, Kalyani; Khan, Abdul Q.; Ahmad, Fareed; Kuttikrishnan, Shilpa; Anver, Rasheeda; Mateo, Jericha M.; Ahmad, Aamir; Bhat, Ajaz A.; Buddenkotte, Joerg; Steinhoff, Martin; Uddin, Shahab... more authors ... less authors ( IMR Press Limited , 2024 , Article)Background: The benzophenanthridine Sanguinarine (Sng) is one of the most abundant root alkaloids with a long history of investigation and pharmaceutical applications. The cytotoxicity of Sng against various tumor cells ... -
Severe atopic dermatitis in an Asian-Arabic population treated with dupilumab: A retrospective observational study
Al Chalabi, Radi; Sherbash, Mohamed; Al-Marri, Fahad; Iqneibi, Mariam; Joy, Febu Elizabeth; Jochebeth, Anh; Al-Khawaga, Sara; Buddenkotte, Joerg; Steinhoff, Martin... more authors ... less authors ( John Wiley and Sons , 2024 , Other)Atopic dermatitis (AD) is a common, inflammatory skin disease characterized by a TH2-deviated immune response in the acute phase and a TH2/TH1/TH17/TH22-skewed immune response in the chronic phase1 associated with pruritus. ... -
Virus-Induced Host Chemokine CCL2 in COVID-19 Pathogenesis: Potential Prognostic Marker and Target of Anti-Inflammatory Strategy
Ansari, Abdul Wahid; Ahmad, Fareed; Alam, Majid Ali; Raheed, Thesni; Zaqout, Ahmed; Al-Maslamani, Muna; Ahmad, Aamir; Buddenkotte, Joerg; Al-Khal, Abdullatif; Steinhoff, Martin... more authors ... less authors (2024 , Article)A wide variety of inflammatory mediators, mainly cytokines and chemokines, are induced during SARS CoV-2 infection. Among these proinflammatory mediators, chemokines tend to play a pivotal role in virus-mediated immunopathology. ...