Browsing by Author "Shurbaji, Samar"
Now showing items 1-14 of 14
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Application of a flow-induced stress wave and investigation of associated injuries on cell monolayers using a parallel plate flow chamber
Shurbaji, Samar; Al-Ruweidi, Mahmoud Khatib A.A.; Ali, Fatma Hassan; Benslimane, Fatiha M.; Yalcin, Huseyin C. ( MDPI , 2020 , Article)© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Parallel plate flow chambers are widely used to expose cultured cells to physiological flows for the investigation of a variety of diseases. These applications ... -
Associations of Vitamin D Receptor Polymorphism rs1544410 with Adiposity Phenotypes
Sharif, Elham; Swaidan, Nuha; Shurbaji, Samar; Rizk, Nasser M. ( MedCrave , 2016 , Article)Background: Vitamin D receptor (VDR) is present on adipocytes, and many studies were performed to investigate the association between polymorphisms in VDR gene with obesity. However, in the Arab Gulf populations, whereas ... -
Cardiac function and blood flow hemodynamics assessment of zebrafish (Danio rerio) using high-speed video microscopy
Fatiha M., Benslimane; Zakaria, Zain Z.; Shurbaji, Samar; Abdelrasool, Mahmoud Khatib Ali; Al-Badr, Mashael Ali H.I.; Al Absi, Enas Said Khalil; Yalcin, Huseyin C.... more authors ... less authors ( Elsevier , 2020 , Article)BackgroundIn the last few decades, zebrafish (Danio rerio) were introduced as a model organism to investigate human diseases including cardiovascular and neuronal disorders. In most zebrafish investigations, cardiac function ... -
Characterization of MXene as a Cancer Photothermal Agent Under Physiological Conditions
Shurbaji, Samar; Manaph, Nimshitha P. Abdul; Ltaief, Samia M.; Al-Shammari, Abeer R.; Elzatahry, Ahmed; Yalcin, Huseyin C.... more authors ... less authors ( Frontiers Media , 2021 , Article)A growing interest has recently emerged in the use of nanomaterials in medical applications. Nanomaterials, such as MXene, have unique properties due to their 2D ultra-thin structure, which is potentially useful in cancer ... -
Development and In Vivo Testing of Smart Nanoparticles for Enhanced Anti-Cancer Activity and Reduced Cardiotoxicity Associated with Tyrosine Kinase Inhibitors
Yalcin, Huseyin; Al-Thani, Hissa; Shurbaji, Samar ( Qatar University Press , 2021 , Poster)Tyrosine kinase inhibitors (TKIs) are new generation of anti-cancer drugs with very high efficiency against cancer cells. However, TKIs are associated with severe cardiotoxicity limiting their clinical benefits. One TKI ... -
Dexamethasone and transdehydroandrosterone significantly reduce pulmonary epithelial cell injuries associated with mechanical ventilation.
Al-Ruweidi, Mahmoud Khatib A A; Ali, Fatma Hassan; Shurbaji, Samar; Popelka, Anton; Yalcin, Huseyin C ( American Physiological Society , 2021 , Article)Many patients who suffer from pulmonary diseases cannot inflate their lungs normally, as they need mechanical ventilation (MV) to assist them. The stress associated with MV can damage the delicate epithelium in small airways ... -
Do changes in ace-2 expression affect sars-cov-2 virulence and related complications: A closer look into membrane-bound and soluble forms
Yalcin, Huseyin C.; Sukumaran, Vijayakumar; Al-Ruweidi, Mahmoud Khatib A.A.; Shurbaji, Samar ( MDPI , 2021 , Article Review)The SARS-CoV-2 virus utilizes angiotensin converting enzyme (ACE-2) for cell entry and infection. This enzyme has important functions in the renin-angiotensin aldosterone system to preserve cardiovascular function. In ... -
Effect of flow-induced shear stress in nanomaterial uptake by cells: Focus on targeted anti-cancer therapy
Shurbaji, Samar; Anlar, Gulsen G.; Hussein, Essraa A.; Elzatahry, Ahmed; Yalcin, Huseyin C. ( MDPI , 2020 , Article)© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Recently, nanomedicines have gained a great deal of attention in diverse biomedical applications, including anti-cancer therapy. Being different from normal tissue, ... -
Mechanosensitive Pathways in Heart Development: Findings from Chick Embryo Studies.
Alser, Maha; Shurbaji, Samar; Yalcin, Huseyin C ( MDPI , 2021 , Article)The heart is the first organ that starts to function in a developing embryo. It continues to undergo dramatic morphological changes while pumping blood to the rest of the body. Genetic regulation of heart development is ... -
Nitric Oxide Releasing Hydrogel Nanoparticles Decreases Epithelial Cell Injuries Associated With Airway Reopening.
Shurbaji, Samar; El-Sherbiny, Ibrahim M; Alser, Maha; Ali, Isra H; Kordi, Haya; Al-Sadi, Ameena; Popelka, Anton; Benslimane, Fatiha; Yacoub, Magdi; Yalcin, Huseyin C... more authors ... less authors ( Frontiers , 2021 , Article)Acute respiratory distress syndrome (ARDS) is an acute inflammatory lung condition. It is characterized by disruption of gas exchange inside the alveoli, accumulation of protein edema, and an increase in lung stiffness. ... -
Reduced Cardiotoxicity of Ponatinib-Loaded PLGA-PEG-PLGA Nanoparticles in Zebrafish Xenograft Model.
Al-Thani, Hissa F; Shurbaji, Samar; Zakaria, Zain Zaki; Hasan, Maram H; Goracinova, Katerina; Korashy, Hesham M; Yalcin, Huseyin C... more authors ... less authors ( MDPI , 2022 , Article)Tyrosine kinase inhibitors (TKIs) are the new generation of anti-cancer drugs with high potential against cancer cells' proliferation and growth. However, TKIs are associated with severe cardiotoxicity, limiting their ... -
The influence of shear stress on nanomaterial's uptake by MDA-231 breast cancer cells
Shurbaji, Samar; Elzatahry, Ahmed; Yalcin, Huseyin ( Qatar University Press , 2020 , Poster)Introduction: Recently, nanotechnology products have been used for a variety of applications including the medical field. Two dimensional (2D) nanomaterials have attracted a growing interest due to its unique properties ... -
Using Zebrafish for Investigating the Molecular Mechanisms of Drug-Induced Cardiotoxicity
zakaria, zain z.; benslimane, fatiha m.; nasrallah, gheyath k.; shurbaji, samar; younes, nadin n.; Mraiche, Fatima; Da’as, Sahar I.; yalcin, huseyin c.... more authors ... less authors ( Hindawi Publishing Corporation , 2018 , Article)Over the last decade, the zebrafish (Danio rerio) has emerged as amodel organismfor cardiovascular research.Zebrafish have several advantages over mammalian models. For instance, the experimental cost of using zebrafish ... -
Zebrafish as a Model for Anticancer Nanomedicine Studies.
Al-Thani, Hissa F; Shurbaji, Samar; Yalcin, Huseyin C ( MDPI , 2021 , Article Review)Nanomedicine is a new approach to fight against cancer by the development of anticancer nanoparticles (NPs) that are of high sensitivity, specificity, and targeting ability to detect cancer cells, such as the ability of ...