Browsing by Author "Priyadharshini Christy, J."
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Computational and modeling approaches to understand the impact of the Fabry's disease causing mutation (D92Y) on the interaction with pharmacological chaperone 1-deoxygalactonojirimycin (DGJ).
Thirumal Kumar, D; Judith, E; Priyadharshini Christy, J; Siva, R; Tayubi, Iftikhar Aslam; Chakraborty, Chiranjib; George Priya Doss, C; Zayed, Hatem... more authors ... less authors ( Elsevier , 2019 , Book chapter)Fabry's disease (FD) is the second most commonly occurring lysosomal storage disorders (LSDs). The mutations in α-galactosidase A (GLA) protein were widely found to be causative for the Fabry's disease. These mutations ... -
Elucidating the role of interacting residues of the MSH2-MSH6 complex in DNA repair mechanism: A computational approach.
Thirumal Kumar, D; Susmita, B; Judith, E; Priyadharshini Christy, J; George Priya Doss, C; Zayed, Hatem... more authors ... less authors ( Elsevier , 2019 , Article)The DNA repair system is crucial to repair the error resulting in DNA replication. MSH2-MSH6 protein complex plays a significant role in maintaining the mismatch repair mechanism. Mutations in the interface between the two ... -
Molecular dynamics-based analyses of the structural instability and secondary structure of the fibrinogen gamma chain protein with the D356V mutation.
Ali, Shabana Kouser; Sneha, P; Priyadharshini Christy, J; Zayed, Hatem; George Priya Doss, C ( Taylor & Francis , 2016 , Article)Mutations in the fibrinogen gamma chain (FGG) gene have been associated with various disorders, such as dysfibrinogenemia, thrombophilia, and hypofibrinogenemia. A literature survey showed that a residue exchange in ...