Browsing by Author "Dhulkifle, Hevna"
Now showing items 1-3 of 3
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6-Formylindolo(3,2-b)carbazole Dampens Inflammation and Reduces Endotoxin-Induced Kidney Injury via Nrf2 Activation
Dhulkifle, Hevna; Sayed, Tahseen S.; Abunada, Hanan H.; Abulola, Sara M.; Alhoshani, Ali; Korashy, Hesham M.; Maayah, Zaid H.... more authors ... less authors ( American Chemical Society (ACS) , 2023 , Article)Patients with sepsis are at a high risk of morbidity and mortality due to multiple organ injuries caused by pathological inflammation. Although sepsis is accompanied by multiple organ injuries, acute renal injury is a ... -
Apabetalone (RVX-208): A Potential Epigenetic Therapy for the Treatment of Cardiovascular, Renal, Neurological, Viral, and Cancer Disorders
Dhulkifle, Hevna; Diab, Mohammad Issam; Algonaiah, Majed; Korashy, Hesham M.; Maayah, Zaid H. ( American Chemical Society (ACS) , 2024 , Article)Bromodomain and extra-terminal domain proteins (BET proteins) are epigenetic reader proteins that have been implicated in regulating gene expression through binding to chromatin and interaction with transcription factors. ... -
Inhibition of cytochrome P450 epoxygenase promotes endothelium-to-mesenchymal transition and exacerbates doxorubicin-induced cardiovascular toxicity
Dhulkifle, Hevna; Therachiyil, Lubna; Hasan, Maram H.; Sayed, Tahseen S.; Younis, Shahd M.; Korashy, Hesham M.; Yalcin, Huseyin C.; Maayah, Zaid H.... more authors ... less authors ( Springer Nature , 2024 , Article)Background: Doxorubicin (DOX) is a potent chemotherapy widely used in treating various neoplastic diseases. However, the clinical use of DOX is limited due to its potential toxic effect on the cardiovascular system. Thus, ...