Browsing by Author "Darwiche, Nadine"
Now showing items 1-6 of 6
-
2-Nucleobase-substituted 4,6-Diaminotriazine Analogs: Synthesis and Anti-cancer Activity in 5-Fluorouracil-Sensitive and Resistant Colorectal Cancer Cells.
Hamze, Khalil; Abdallah, Rola H; Younis, Nour K; Fardoun, Manal; Darwiche, Nadine; Kobeissy, Firas; Iratni, Rabah; Bouhadir, Kamal; Eid, Ali H... more authors ... less authors ( Bentham Science Publishers , 2022 , Article)Cancer continues to be the second leading cause of death worldwide with colorectal cancer (CRC) being the third most common type. Despite significant advances in cancer therapies, current treatment of CRC remains suboptimal. ... -
Inflammasomes as biomarkers and therapeutic targets in traumatic brain injury and related-neurodegenerative diseases: A comprehensive overview
Dania, Kattan; Barsa, Chloe; Mekhijian, Sarin; Shakkour, Zaynab; Jammoul, Maya; Doumit, Mark; Zabala, Maria Camila Pareja; Darwiche, Nadine; Eid, Ali H.; Mechref, Yehia; Wang, Kevin K.; de Rivero Vaccari, Juan Pablo; Munoz Pareja, Jennifer C.; Kobeissy, Firas... more authors ... less authors ( Elsevier , 2023 , Article)Given the ambiguity surrounding traumatic brain injury (TBI) pathophysiology and the lack of any Food and Drug Administration (FDA)-approved neurotherapeutic drugs, there is an increasing need to better understand the ... -
Novel therapeutic strategies for spinal osteosarcomas
M. Akhtar, Anwar; El-Baba, Chirine; Elnaggar, Muhammed H.; Elkholy, Yasmeen O.; Mottawea, Mohamed; Johar, Dina; Al Shehabi, Tuqa S.; Kobeissy, Firas; Moussalem, Charbel; Massaad, Elie; Omeis, Ibrahim; Darwiche, Nadine; Eid, A.H.... more authors ... less authors ( Elsevier , 2020 , Article Review)At the dawn of the third millennium, cancer has become the bane of twenty-first century man, and remains a predominant public health burden, affecting welfare and life expectancy globally. Spinal osteogenic sarcoma, a ... -
Retinoids and Reactive Oxygen Species in Cancer Cell Death and Therapeutics
El-Baba, Chirine; Eid, Ali H.; Shaito, Abdallah; Kobeissy, Firas; Darwiche, Nadine ( Springer Nature , 2022 , Book chapter)Retinoids are a large family of structurally related natural and synthetic molecules that exhibit a variety of effects in embryogenesis and adult life. The parent compound of retinoids is vitamin A which was first discovered ... -
Thromboinflammatory Processes at the Nexus of Metabolic Dysfunction and Prostate Cancer: The Emerging Role of Periprostatic Adipose Tissue
Alzaim, Ibrahim; Al-Saidi, Aya; Hammoud, Safaa H.; Darwiche, Nadine; Al-Dhaheri, Yusra; Eid, Ali H.; El-Yazbi, Ahmed F.... more authors ... less authors ( MDPI , 2022 , Article)The increased global prevalence of metabolic disorders including obesity, insulin resistance, metabolic syndrome and diabetes is mirrored by an increased incidence of prostate cancer (PCa). Ample evidence suggests that ... -
Unveiling a Biomarker Signature of Meningioma: the Need for a Panel of Genomic, Epigenetic, Proteomic, and RNA Biomarkers to Advance Diagnosis and Prognosis
Halabi, Reem; Dakroub, Fatima; Haider, Mohammad Z.; Patel, Stuti; Amhaz, Nayef A.; Reslan, Mohammad A.; Eid, Ali H.; Mechref, Yehia; Darwiche, Nadine; Kobeissy, Firas H.; Omeis, Ibrahim; Shaito, Abdullah... more authors ... less authors ( preprints , 2023 , Preprint)Meningiomas are the most prevalent primary intracranial tumors. The majority are benign but can undergo dedifferentiation in grades classified from I to III. Meningiomas tremendous variability in tumor behavior and slow ...