Browsing by Author "Vito, Pasquale"
Now showing items 1-5 of 5
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CARMA2sh and ULK2 control pathogen-associated molecular patterns recognition in human keratinocytes: psoriasis-linked CARMA2sh mutants escape ULK2 censorship
( Nature , 2017 , Article)The molecular complexes formed by specific members of the family of CARMA proteins, the CARD domain-containing adapter molecule BCL10 and MALT1 (CBM complex) represent a central hub in regulating activation of the pleiotropic ... -
Effect of CARMA 2sh gene in Mouse embryonic stem (ES) cells
(2017 , Poster)CARMA2 belongs to the CARMA family of proteins. They are involved in the regulation and activation of NF-κB that have a central role in the control of immune and inflammatory response, and cell survival and proliferation. ... -
Expression of active and inactive forms of CIK and CARMA 2sh proteins in Normal Human Epidermal Keratinocytes (NHEK)
(2016 , Poster)Psoriasis is a debilitating skin disease affecting approximately 23% of human population. The disease is considered to have key genetic underpinning and genome wide association studies and meta analysis have identified ... -
In Vitro Analysis of Psoriasis Linked CARMA2sh Gene in Keratinocytes and Mouse Embryonic Stem Cells towards Developing a Murine Transgenic Model
( American Association For Laboratory Animal Science , 2017 , Poster)Psoriasis is a debilitating skin disease affecting approximately 23% of human population. Genome-wide association studies have identified more than 40 susceptibility loci for psoriasis. CARMA2 proteins play a major role ... -
NF-κB Essential MOdulator (NEMO) Is Critical for Thyroid Function
( American Society for Biochemistry and Molecular Biology , 2016 , Article)The I-κB kinase (IKK) subunit NEMO/IKKγ (NEMO) is an adapter molecule that is critical for canonical activation of NF-κB, a pleiotropic transcription factor controlling immunity, differentiation, cell growth, tumorigenesis ...
