Browsing by Author "Tomei, Sara"
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Immunomodulatory effects of vitamin d supplementation in a deficient population
Garand, Mathieu; Toufiq, Mohammed; Singh, Parul; Huang, Susie Shih Yin; Tomei, Sara; Mathew, Rebecca; Mattei, Valentina; Al Wakeel, Mariam; Sharif, Elham; Al Khodor, Souhaila... more authors ... less authors ( Multidisciplinary Digital Publishing Institute (MDPI) , 2021 , Article)In addition to its canonical functions, vitamin D has been proposed to be an important mediator of the immune system. Despite ample sunshine, vitamin D deficiency is prevalent (>80%) in the Middle East, resulting in a high ... -
The role of polymorphisms in vitamin d-related genes in response to vitamin d supplementation
Tomei, Sara; Singh, Parul; Mathew, Rebecca; Mattei, Valentina; Garand, Mathieu; Alwakeel, Mariam; Sharif, Elham; Khodor, Souhaila Al... more authors ... less authors ( Multidisciplinary Digital Publishing Institute (MDPI) , 2020 , Article)Background. Vitamin D deficiency represents a major healthcare problem. Vitamin D status is influenced by genetic and environmental determinants. Several observational studies have evaluated the association of single-nucleotide ... -
Thousands of Qatari genomes inform human migration history and improve imputation of Arab haplotypes
Razali, Rozaimi Mohamad; Rodriguez-Flores, Juan; Ghorbani, Mohammadmersad; Naeem, Haroon; Aamer, Waleed; Aliyev, Elbay; Jubran, Ali; Ismail, Said I.; Al-Muftah, Wadha; Badji, Radja; Mbarek, Hamdi; Darwish, Dima; Fadl, Tasnim; Yasin, Heba; Ennaifar, Maryem; Abdellatif, Rania; Alkuwari, Fatima; Alvi, Muhammad; Al-Sarraj, Yasser; Saad, Chadi; Althani, Asmaa; Fethnou, Eleni; Qafoud, Fatima; Alkhayat, Eiman; Afifi, Nahla; Tomei, Sara; Liu, Wei; Lorenz, Stephan; Syed, Najeeb; Almabrazi, Hakeem; Vempalli, Fazulur Rehaman; Temanni, Ramzi; Saqri, Tariq Abu; Khatib, Mohammedhusen; Hamza, Mehshad; Zaid, Tariq Abu; El Khouly, Ahmed; Pathare, Tushar; Poolat, Shafeeq; Al-Ali, Rashid; Albagha, Omar; Al-Khodor, Souhaila; Alshafai, Mashael; Badii, Ramin; Chouchane, Lotfi; Estivill, Xavier; Fakhro, Khalid A.; Mokrab, Younes; Puthen, Jithesh V.; Suhre, Karsten; Tatari, Zohreh; Clark, Andrew G.... more authors ... less authors ( Nature Research , 2021 , Article)Arab populations are largely understudied, notably their genetic structure and history. Here we present an in-depth analysis of 6,218 whole genomes from Qatar, revealing extensive diversity as well as genetic ancestries ... -
Understanding the genetics of early onset obesity in a cohort of children from Qatar.
Mohammed, Idris; Haris, Basma; Al-Barazenji, Tara; Vasudeva, Dhanya; Tomei, Sara; Al Azwani, Iman; Dauleh, Hajar; Shehzad, Saira; Chirayath, Shiga; Mohamadsalih, Ghassan; Petrovski, Goran; Khalifa, Amel; Love, Donald R; Al-Shafai, Mashael; Hussain, Khalid... more authors ... less authors ( Oxford University Press , 2023 , Article)Monogenic obesity is a rare form of obesity due to pathogenic variants in genes implicated in the leptin-melanocortin signaling pathway and accounts for around 5% of severe early onset obesity. Mutations in the genes ...