Browsing by Author "Alhmoud, Jehad F."

Now showing items 1-4 of 4

    • DNA Damage/Repair Management in Cancers 

      Alhmoud, Jehad F; Woolley, John F; Al Moustafa, Ala-Eddin; Malki, Mohammed Imad ( MDPI , 2020 , Article Review)
      DNA damage is well recognized as a critical factor in cancer development and progression. DNA lesions create an abnormal nucleotide or nucleotide fragment, causing a break in one or both chains of the DNA strand. When DNA ...

    • DNA Damage/Repair Management in Cancers 

      Alhmoud, Jehad F.; Woolley, John F.; Al Moustafa, Ala-Eddin; Malki, Mohammed Imad ( Routledge , 2021 , Book chapter)
      DNA damage can alter nucleotide sequences and lead to expression of dysfunctional proteins that impact normal cellular physiology. Sources of DNA damage can be endogenous or exogenous and include reactive oxygen species ...

    • Investigation of the Effect of Imatinib and Hydroxyurea Combination Therapy on Hematological Parameters and Gene Expression in Chronic Myeloid Leukemia (CML) Patients 

      Al-Amleh, Esraa K.; Al-Sanabra, Ola M.; Alqaisi, Khalid M.; Alqaraleh, Moath; Al-Nahal, Jumana; ... more authors ( MDPI , 2022 , Article)
      (1) Background: Chronic myeloid leukemia is defined as the neoplastic development of mostly myeloid cells in the bone marrow. Several treatments, including chemotherapy, radiation, hormone treatment, and immunological ...

    • Targeting DNA Repair Pathways in Hematological Malignancies. 

      Alhmoud, Jehad F; Mustafa, Ayman G; Malki, Mohammed Imad ( MDPI , 2020 , Article Review)
      DNA repair plays an essential role in protecting cells that are repeatedly exposed to endogenous or exogenous insults that can induce varying degrees of DNA damage. Any defect in DNA repair mechanisms results in multiple ...