Browsing by Author "Agha, Maha V"
Now showing items 1-4 of 4
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Metabolic signature of obesity-associated insulin resistance and type 2 diabetes.
Al-Sulaiti, Haya; Diboun, Ilhame; Agha, Maha V; Mohamed, Fatima F S; Atkin, Stephen; Dömling, Alex S; Elrayess, Mohamed A; Mazloum, Nayef A... more authors ... less authors ( BMC , 2019 , Article)Obesity is associated with an increased risk of insulin resistance and type 2 diabetes mellitus (T2DM). However, some obese individuals maintain their insulin sensitivity and exhibit a lower risk of associated comorbidities. ... -
Signal transducer and activator of transcription 3 (Stat3) suppresses stat1/interferon signaling pathway and inflammation in senescent preadipocytes
Madani, Aisha Y.; Majeed, Yasser; Abdesselem, Houari B.; Agha, Maha V.; Vakayil, Muneera; Al Sukhun, Nour K.; Halabi, Najeeb M.; Kumar, Pankaj; Hayat, Shahina; Elrayess, Mohamed A.; Rafii, Arash; Suhre, Karsten; Mazloum, Nayef A.... more authors ... less authors ( MDPI , 2021 , Article)© 2021 by the authors. Licensee MDPI, Basel, Switzerland. Obesity promotes premature aging and dysfunction of white adipose tissue (WAT) through the accumulation of cellular senescence. The senescent cells burden in WAT ... -
Signal Transducer and Activator of Transcription 3 (STAT3) Suppresses STAT1/Interferon Signaling Pathway and Inflammation in Senescent Preadipocytes.
Madani, Aisha Y; Majeed, Yasser; Abdesselem, Houari B; Agha, Maha V; Vakayil, Muneera; Sukhun, Nour K Al; Halabi, Najeeb M; Kumar, Pankaj; Hayat, Shahina; Elrayess, Mohamed A; Rafii, Arash; Suhre, Karsten; Mazloum, Nayef A... more authors ... less authors ( MDPI , 2021 , Article)Obesity promotes premature aging and dysfunction of white adipose tissue (WAT) through the accumulation of cellular senescence. The senescent cells burden in WAT has been linked to inflammation, insulin-resistance (IR), ... -
SIRT1 promotes lipid metabolism and mitochondrial biogenesis in adipocytes and coordinates adipogenesis by targeting key enzymatic pathways.
Majeed, Yasser; Halabi, Najeeb; Madani, Aisha Y; Engelke, Rudolf; Bhagwat, Aditya M; Abdesselem, Houari; Agha, Maha V; Vakayil, Muneera; Courjaret, Raphael; Goswami, Neha; Hamidane, Hisham Ben; Elrayess, Mohamed A; Rafii, Arash; Graumann, Johannes; Schmidt, Frank; Mazloum, Nayef A... more authors ... less authors ( Nature Research , 2021 , Article)The NAD-dependent deacetylase SIRT1 controls key metabolic functions by deacetylating target proteins and strategies that promote SIRT1 function such as SIRT1 overexpression or NAD boosters alleviate metabolic complications. ...