Browsing by Author "Naja, Khaled"
Now showing items 1-19 of 19
-
Advancements in precision medicine: multi-omics approach for tailored metformin treatment in type 2 diabetes
( Frontiers Media SA , 2024 , Article Review)Metformin has become the frontline treatment in addressing the significant global health challenge of type 2 diabetes due to its proven effectiveness in lowering blood glucose levels. However, the reality is that many ... -
Association between antioxidant metabolites and N-terminal fragment brain natriuretic peptides in insulin-resistant individuals.
( Lippincott, Williams & Wilkins , 2024 , Article)Oxidative stress plays a pivotal role in the development of metabolic syndrome, including heart failure and insulin resistance. The N-terminal fragment of brain natriuretic peptide (NT-proBNP) has been associated with ... -
Comparing the metabolic signatures of obesity defined by waist circumference, waist-hip ratio, or BMI
( John Wiley and Sons Inc , 2024 , Article)Objective: Measuring obesity is crucial for assessing health risks and developing effective prevention and treatment strategies. The most common methods used to measure obesity include BMI, waist circumference, and waist-hip ... -
Eight weeks of aerobic exercise, but not four, improves insulin sensitivity and cardiovascular performance in young women
( Nature Research , 2025 , Article)Regular aerobic exercise has a significant impact on glucose metabolism and lipid profiles, contributing to overall health improvement. However, evidence for optimal exercise duration to achieve these effects is limited. ... -
Indoleacetylglutamine Pathway Is a Potential Biomarker for Cardiovascular Diseases
( Multidisciplinary Digital Publishing Institute (MDPI) , 2025 , Article)Cardiovascular diseases (CVDs) remain a leading cause of global morbidity and mortality. Metabolomics allows for the identification of important biomarkers for CVDs, essential for early detection and risk assessment. This ... -
Joint Effects of Exercise and Ramadan Fasting on Telomere Length: Implications for Cellular Aging
( MDPI , 2024 , Article)Aging is a fundamental biological process that progressively impairs the functionality of the bodily systems, leading to an increased risk of diseases. Telomere length is one of the most often used biomarkers of aging. ... -
Lipid Subclasses Differentiate Insulin Resistance by Triglyceride-Glucose Index
( Multidisciplinary Digital Publishing Institute (MDPI) , 2025 , Article)Background: Insulin resistance is a key driver of metabolic syndrome and related disorders, yet its underlying metabolic alterations remain incompletely understood. The Triglyceride-Glucose (TyG) index is an emerging, ... -
Mechanisms of body fat distribution and gluteal-femoral fat protection against metabolic disorders
( Frontiers Media SA , 2024 , Article Review)Obesity is a major health problem that affects millions of individuals, and it is associated with metabolic diseases including insulin resistance (IR), type 2 diabetes (T2D), and cardiovascular diseases (CVDs). However, ... -
Metabolic signatures of combined exercise and fasting: an expanded perspective on previous telomere length findings
( Frontiers Media SA , 2024 , Article)Introduction: Aging is a complex process marked by a gradual decline in physiological function and increased susceptibility to diseases. Telomere length is frequently regarded as one of the primary biomarkers of aging. ... -
Metformin increases 3-hydroxy medium chain fatty acids in patients with type 2 diabetes: a cross-sectional pharmacometabolomic study
( Frontiers Media SA , 2024 , Article)Background: Metformin is a drug with a long history of providing benefits in diabetes management and beyond. The mechanisms of action of metformin are complex, and continue to be actively debated and investigated. The aim ... -
N-lactoyl amino acids are potential biomarkers for insulin resistance and diabetic complications
( Wiley , 2025 , Article)Aims: N-lactoyl amino acids (Lac-AA) are emerging as crucial players in metabolic research, with potential implications for disease mechanisms and therapeutic interventions. This study exploress the role of Lac-AA in insulin ... -
N-Lactoyl amino acids as metabolic biomarkers differentiating low and high exercise response
( Institute of Sport , 2025 , Article)Aerobic physical exercise has significant benefits for cardiovascular health; however, some individuals experience no benefit or even adverse effects. One reason for poor tolerance to aerobic exercise may be a low percentage ... -
N-Lactoyl Amino Acids: Emerging Biomarkers in Metabolism and Disease
( Wiley , 2025 , Article)N-lactoyl amino acids (Lac-AA) form an emerging class of metabolites that have gained significant attention in recent years due to their ubiquitous presence in different biological systems and potential roles in various ... -
N-Lactoyl amino acids: insights from metabolite genome-wide association studies and phenome-wide association analysis
( Oxford University Press , 2025 , Article)N-lactoyl-amino acids (Lac-AA) are emerging as important metabolites with diverse physiological roles. This study integrates metabolomics and genomics to investigate the genetic determinants and clinical relevance of three ... -
Pharmacometabolomic Approach to Investigate the Response to Metformin in Patients with Type 2 Diabetes: A Cross-Sectional Study
( MDPI , 2023 , Article)Metformin constitutes the foundation therapy in type 2 diabetes (T2D). Despite its multiple beneficial effects and widespread use, there is considerable inter-individual variability in response to metformin. Our objective ... -
Pharmacometabolomics of sulfonylureas in patients with type 2 diabetes: a cross-sectional study
( Frontiers Media SA , 2024 , Article)Background: Sulfonylureas have been a longstanding pharmacotherapy in the management of type 2 diabetes, with potential benefits beyond glycemic control. Although sulfonylureas are effective, interindividual variability ... -
Targeted Inhibition of GATA-3 by Pyrrothiogatain: Implications for Adipocyte Biology and Inflammatory Response
( Multidisciplinary Digital Publishing Institute (MDPI) , 2025 , Article)GATA-3 is a master regulator of preadipocyte differentiation and function. Pharmacological or genetic targeting of GATA-3 will allow us to understand the function of GATA-3 in regulating metabolism, insulin signaling, and ... -
The influence of circadian rhythm disruption during Ramadan on metabolic responses to physical activity: a pilot study
( Frontiers Media SA , 2025 , Article)Background: Circadian rhythms and sleep patterns are important regulators of metabolic health. During Ramadan intermittent fasting (RIF), the sleep–wake cycles are often disrupted, which can affect physical activity (PA) ... -
Variability of blue carbon storage in arid evaporitic environment of two coastal Sabkhas or mudflats
( Nature Research , 2023 , Article)Coastal Sabkhas are mudflats found in arid coastal regions that are located within the supratidal zone when high rates of evaporation lead to high salinity. While evaporitic minerals often accumulate underneath the surface, ...
