Browsing by Author "Douek, Daniel C"

Now showing items 1-3 of 3

    • Activation Dynamics and Immunoglobulin Evolution of Pre-existing and Newly Generated Human Memory B cell Responses to Influenza Hemagglutinin. 

      Andrews, Sarah F; Chambers, Michael J; Schramm, Chaim A; Plyler, Jason; Raab, Julie E; ... more authors ( Elsevier , 2019 , Article)
      Vaccine-induced memory B cell responses to evolving viruses like influenza A involve activation of pre-existing immunity and generation of new responses. To define the contribution of these two types of responses, we ...

    • Design of Nanoparticulate Group 2 Influenza Virus Hemagglutinin Stem Antigens That Activate Unmutated Ancestor B Cell Receptors of Broadly Neutralizing Antibody Lineages. 

      Corbett, Kizzmekia S; Moin, Syed M; Yassine, Hadi M; Cagigi, Alberto; Kanekiyo, Masaru; ... more authors ( American Society for Microbiology , 2019 , Article)
      Influenza vaccines targeting the highly conserved stem of the hemagglutinin (HA) surface glycoprotein have the potential to protect against pandemic and drifted seasonal influenza viruses not covered by current vaccines. ...

    • Vaccine-Induced Antibodies that Neutralize Group 1 and Group 2 Influenza A Viruses 

      Joyce, M. Gordon; Wheatley, Adam K.; Thomas, Paul V.; Chuang, Gwo-Yu; Soto, Cinque; ... more authors ( Elsevier Inc. , 2016 , Article)
      Antibodies capable of neutralizing divergent influenza A viruses could form the basis of a universal vaccine. Here, from subjects enrolled in an H5N1 DNA/MIV-prime-boost influenza vaccine trial, we sorted hemagglutinin ...