Browsing by Author "Malki, Ahmed"
Now showing items 1-15 of 15
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Antitumor Activities of the Novel Isosteviol Derivative 10C Against Liver Cancer
( International Institute of Anticancer Research , 2017 , Article)Background/Aim. Hepatocellular carcinoma (HCC) is the most common type of liver cancer and the fifth most common primary malignancy with worldwide increasing incidence. The current study aims to investigate the anticancer ... -
Association between metabolically healthy obesity and metastasis in lung cancer patients – a systematic review and meta-analysis
( Frontiers Media , 2023 , Article Review)Background: Many clinical trials have looked at the relationship between obesity and lung cancer (LC), however, there is scarcity of literature specifically addressing the association between metabolically healthy obesity ... -
Association between Soft Drink Consumption and Aggressive Behaviour among a Quarter Million Adolescents from 64 Countries Based on the Global School-Based Student Health Survey (GSHS)
( MDPI , 2020 , Article)Soft drink consumption has become a significant public health concern that is associated with various adverse health outcomes.We aim to examine the association between soft drink consumption and aggressive behavior among ... -
Discovery of Novel Pyridine Derivatives as Anti-Cancer Agents
(2015 , Master Thesis)The International Agency for Research on Cancer indicated that cancer burden was raised in 2012 to 14.1 million incidence cases and 8.2 mortality cases. Consequently, novel approaches are urgently required for further ... -
Editorial: Vascular Endothelial Growth Factor Inhibitors: Blocking Angiogenesis and Improving Outcomes.
( OMICS International , 2015 , Article)Tumor tissues are just like normal tissues; require nutrients, oxygen and the ability to evacuate waste products and CO2, the process of angiogenesis or (tumor-associated vascularization) addresses these needs to tumor ... -
In vitro and in vivo efficacy of a novel quinuclidinone derivative against breast cancer
( International Institute of Anticancer Research , 2014 , Article)Previously, our laboratory reported on novel quinuclidinone derivatives that cause cytotoxicity in human non-small lung carcinoma epithelial cells null for p53 (H1299). The current study aims to investigate the effect of ... -
IN-DEPTH CHARACTERIZATION OF MESENCHYMAL STEM CELLS-DERIVED EXTRACELLULAR VESICLES USING QUANTITATIVE PROTEOMICS
(2016 , Master Thesis)As they home in on injured tissue, modulate the immune system and support tissue repairing, mesenchymal stem cells (MSCs) are considered a promising tool for many therapeutic applications. In vitro, MSCs have been shown ... -
Microfluidics integrated biosensors: A leading technology towards lab-on-a-chip and sensing applications
( Multidisciplinary Digital Publishing Institute (MDPI) , 2015 , Article)A biosensor can be defined as a compact analytical device or unit incorporating a biological or biologically derived sensitive recognition element immobilized on a physicochemical transducer to measure one or more analytes. ... -
Molecular Mechanisms of Colon Cancer Progression and Metastasis: Recent Insights and Advancements.
( MDPI , 2020 , Article Review)Colorectal cancer (CRC), the third most common type of cancer, is the second leading cause of cancer-related mortality rates worldwide. Although modern research was able to shed light on the pathogenesis of CRC and provide ... -
New 3-Cyano-2-Substituted Pyridines Induce Apoptosis in MCF 7 Breast Cancer Cells
( Multidisciplinary Digital Publishing Institute (MDPI) , 2016 , Article)The synthesis of new 3-cyano-2-substituted pyridines bearing various pharmacophores and functionalities at position 2 is described. The synthesized compounds were evaluated for their in vitro anti-cancer activities on five ... -
Novel 1,5-diphenyl-6-substituted 1H-pyrazolo[3,4-d]pyrimidin-4(5H)-ones induced apoptosis in RKO colon cancer cells
( Taylor & Francis , 2015 , Article)Novel 1,5-diphenyl-6-substituted-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-ones were synthesized and characterized. All compounds were screened for their anti-proliferative activities in five different cancer cell lines. The results ... -
Novel Quinuclidinone Derivatives Induced Apoptosis in Human Breast Cancer via Targeting P53
( Elsevier , 2017 , Article)Small molecules that can target human cancers have been highly sought to increase the anticancer efficacy, the present work describes the design and synthesis of novel series of five quinuclidinone derivatives (2a-2e). ... -
Vascular Endothelial Dysfunction as the Mechanism for Development of Obesity
(2018 , Master Thesis)Obesity is one of the major public health issues in the world with a rapid increase in its prevalence. According to the last public health report from supreme public health in Qatar in 2012, 71.8 % of the women were ... -
VISUALIZATION OF FACTOR VIII WITH FLOW-CYTOMETRY AS A TOOL FOR NOVEL GENE THERAPY APPROACH IN HEMOPHILIA A
(2019 , Master Thesis)Haemophilia A is a genetic X-linked disorder, characterized by coagulation Factor VIII (FVIII) deficiency and leading to pathological bleedings. The disease occurs in a rate of 1 in 5000 males’ births. The treatment is the ... -
Vitamin D Signaling in Inflammation and Cancer: Molecular Mechanisms and Therapeutic Implications
( MDPI , 2020 , Article Review)Vitamin D and its active metabolites are important nutrients for human skeletal health. UV irradiation of skin converts 7-dehydrocholesterol into vitamin D3, which metabolized in the liver and kidneys into its active form, ...
