Browsing by Author "Thanassoulas, Angelos"
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ApoM binds endotoxin contributing to neutralization and clearance by High Density Lipoprotein.
Mousa, Hanaa; Thanassoulas, Angelos; Zughaier, Susu M ( Elsevier , 2023 , Article)HDL possesses anti-inflammatory properties, however, the exact mechanism is not fully understood. Endotoxin is a potent inducers of TLR4 signaling, leading to inflammatory mediators' release. It has been estimated that ... -
Arrhythmogenic calmodulin E105A mutation alters cardiac RyR2 regulation leading to cardiac dysfunction in zebrafish
Da'as, Sahar I; Thanassoulas, Angelos; Calver, Brian L; Beck, Konrad; Salem, Rola; Saleh, Alaaeldin; Kontogianni, Iris; Al-Maraghi, Ali; Nasrallah, Gheyath K; Safieh-Garabedian, Bared; Toft, Egon; Nounesis, George; Lai, F Anthony; Nomikos, Michail... more authors ... less authors ( Wiley , 2019 , Article)Calmodulin (CaM) is a universal calcium (Ca )-binding messenger that regulates many vital cellular events. In cardiac muscle, CaM associates with ryanodine receptor 2 (RyR2) and regulates excitation-contraction coupling. ... -
The Arrhythmogenic E105A CAM Mutation Dysregulates Normal Cardiac Function in Zebrafish by Altering CAM-Ca2+ and CAM-RyR2 Interactions
Nomikos, Michail; I. Da’as, Sahar; Thanassoulas, Angelos; Salem, Rola; L. Calver, Brian; Saleh, Alaaeldin; Al-Maraghi, Ali; K. Nasrallah, Gheyath; Safieh-Garabedian, Bared; Toft, Egon; Nounesis, George; Lai, F. Anthony... more authors ... less authors ( Elsevier , 2019 , Article)Calmodulin (CaM) is a multifunctional calcium (Ca2+)-binding messenger that directly interacts with the cardiac ryanodine receptor 2 (RyR2), a large transmembrane Ca2+ channel that mediates Ca2+ release from the sarcoplasmic ... -
Calmodulin Interacts and Regulates Enzyme Activity of the Mammalian Sperm Phospholipase C
Nomikos, Michail; Thanassoulas, Angelos; L. Calver, Brian; Theodoridou, Maria; Buntwal, Luke; Sideratou, Zili; Nounesis, George; Lai, F. Anthony... more authors ... less authors ( Elsevier , 2017 , Article)Sperm-specific Phospholipase C zeta (PLCζ) is widely considered to be the sole, physiological stimulus responsible for the generation of Ca2+ oscillations that induce egg activation and early embryo development during ... -
Calmodulin Mutations Associated with Congenital Cardiac Disease Display Novel Biophysical and Biochemical Characteristics
Nomikos, Michail; Thanassoulas, Angelos; L. Calver, Brian; Beck, Konrad; Vassilakopoulou, Vyronia; Buntwal, Luke; Konotgianni, Iris; Smith, Adrian; Safieh-Garabedian, Bared; Livaniou, Evangelia; Steen Toft, Egon; Nounesis, George... more authors ... less authors ( Elsevier , 2018 , Article)Calmodulin (CaM) is a cytoplasmic multifunctional calcium (Ca2+)-binding messenger that interacts with the cardiac ryanodine receptor (RyR2), a large transmembrane Ca2+ channel that mediates Ca2+ release from the sarcoplasmic ... -
Defective Interaction of Cam with RyR2 Cam-Binding Pocket Might Contribute to Arrhythmogenic Cardiac Disease
Nomikos, Michail; Thanassoulas, Angelos; Vassilakopoulou, Vyronia; L. Calver, Brian; Livaniou, Evangelia; Safieh-Garabedian, Bared; Toft, Egon; Nounesis, George; Lai, F. Anthony... more authors ... less authors ( Elsevier , 2020 , Article)Ryanodine receptor 2 (RyR2) is a large transmembrane calcium (Ca2+) release channel that mediates Ca2 release from the sarcoplasmic reticulum to activate cardiac muscle contraction. Calmodulin (CaM) regulation of RyR2 is ... -
Essential Role of Sperm-Specific PLC-Zeta in Egg Activation and Male Factor Infertility: An Update.
Saleh, Alaaeldin; Kashir, Junaid; Thanassoulas, Angelos; Safieh-Garabedian, Bared; Lai, F Anthony; Nomikos, Michail... more authors ... less authors ( Frontiers Media , 2020 , Article Review)Sperm-specific phospholipase C zeta (PLCζ) is widely considered to be the physiological stimulus responsible for generating calcium (Ca) oscillations that induce egg activation and early embryonic development during mammalian ... -
Mutations in PLCδ1 associated with hereditary leukonychia display divergent PIP2 hydrolytic function
Nomikos, Michail; Thanassoulas, Angelos; Beck, Konrad; Theodoridou, Maria; Kew, Jasmine; Kashir, Junaid; Calver, Brian L.; Matthews , Emily; Rizkallah, Pierre; Sideratou, Zili; Nounesis, George; Lai, F. Anthony... more authors ... less authors ( Blackwell Publishing Ltd , 2016 , Article)Hereditary leukonychia is a rare genetic nail disorder characterized by distinctive whitening of the nail plate of all 20 nails. Hereditary leukonychia may exist as an isolated feature, or in simultaneous occurrence with ... -
Pyridoxine non-responsive p.R336C mutation alters the molecular properties of cystathionine beta-synthase leading to severe homocystinuria phenotype
Al-Sadeq, Duaa W.; Thanassoulas, Angelos; Islam, Zeyaul; Kolatkar, Prasanna; Al-Dewik, Nader; Safieh-Garabedian, Bared; Nasrallah, Gheyath K.; Nomikos, Michail... more authors ... less authors ( Elsevier , 2022 , Article)The prevalence of homocystinuria in Qatar is 1:1800, mainly due to a founder missense mutation p.R336C. • The cystathionine beta-synthase (CBS) R336C mutant was bacterially expressed, purified and its molecular properties ... -
SPERM FACTORS AND EGG ACTIVATION The structure and function relationship of sperm PLCZ1
Thanassoulas, Angelos; Swann, Karl; Lai, F. Anthony; Nomikos, Michail ( BioScientifica , 2022 , Article Review)In 2002, sperm-specific phospholipase C zeta1 (PLCZ1) was discovered and through these 20 years, it has been established as the predominant sperm oocyte-activating factor. PLCZ1 cRNA expression or direct protein microinjection ...