Browsing by Author "Thanassoulas, Angelos"
Now showing items 1-10 of 10
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ApoM binds endotoxin contributing to neutralization and clearance by High Density Lipoprotein.
( Elsevier , 2023 , Article)HDL possesses anti-inflammatory properties, however, the exact mechanism is not fully understood. Endotoxin is a potent inducers of TLR4 signaling, leading to inflammatory mediators' release. It has been estimated that ... -
Arrhythmogenic calmodulin E105A mutation alters cardiac RyR2 regulation leading to cardiac dysfunction in zebrafish
( Wiley , 2019 , Article)Calmodulin (CaM) is a universal calcium (Ca )-binding messenger that regulates many vital cellular events. In cardiac muscle, CaM associates with ryanodine receptor 2 (RyR2) and regulates excitation-contraction coupling. ... -
The Arrhythmogenic E105A CAM Mutation Dysregulates Normal Cardiac Function in Zebrafish by Altering CAM-Ca2+ and CAM-RyR2 Interactions
( Elsevier , 2019 , Article)Calmodulin (CaM) is a multifunctional calcium (Ca2+)-binding messenger that directly interacts with the cardiac ryanodine receptor 2 (RyR2), a large transmembrane Ca2+ channel that mediates Ca2+ release from the sarcoplasmic ... -
Calmodulin Interacts and Regulates Enzyme Activity of the Mammalian Sperm Phospholipase C
( Elsevier , 2017 , Article)Sperm-specific Phospholipase C zeta (PLCζ) is widely considered to be the sole, physiological stimulus responsible for the generation of Ca2+ oscillations that induce egg activation and early embryo development during ... -
Calmodulin Mutations Associated with Congenital Cardiac Disease Display Novel Biophysical and Biochemical Characteristics
( Elsevier , 2018 , Article)Calmodulin (CaM) is a cytoplasmic multifunctional calcium (Ca2+)-binding messenger that interacts with the cardiac ryanodine receptor (RyR2), a large transmembrane Ca2+ channel that mediates Ca2+ release from the sarcoplasmic ... -
Defective Interaction of Cam with RyR2 Cam-Binding Pocket Might Contribute to Arrhythmogenic Cardiac Disease
( Elsevier , 2020 , Article)Ryanodine receptor 2 (RyR2) is a large transmembrane calcium (Ca2+) release channel that mediates Ca2 release from the sarcoplasmic reticulum to activate cardiac muscle contraction. Calmodulin (CaM) regulation of RyR2 is ... -
Essential Role of Sperm-Specific PLC-Zeta in Egg Activation and Male Factor Infertility: An Update.
( Frontiers Media , 2020 , Article Review)Sperm-specific phospholipase C zeta (PLCζ) is widely considered to be the physiological stimulus responsible for generating calcium (Ca) oscillations that induce egg activation and early embryonic development during mammalian ... -
Mutations in PLCδ1 associated with hereditary leukonychia display divergent PIP2 hydrolytic function
( Blackwell Publishing Ltd , 2016 , Article)Hereditary leukonychia is a rare genetic nail disorder characterized by distinctive whitening of the nail plate of all 20 nails. Hereditary leukonychia may exist as an isolated feature, or in simultaneous occurrence with ... -
Pyridoxine non-responsive p.R336C mutation alters the molecular properties of cystathionine beta-synthase leading to severe homocystinuria phenotype
( Elsevier , 2022 , Article)The prevalence of homocystinuria in Qatar is 1:1800, mainly due to a founder missense mutation p.R336C. • The cystathionine beta-synthase (CBS) R336C mutant was bacterially expressed, purified and its molecular properties ... -
SPERM FACTORS AND EGG ACTIVATION The structure and function relationship of sperm PLCZ1
( BioScientifica , 2022 , Article Review)In 2002, sperm-specific phospholipase C zeta1 (PLCZ1) was discovered and through these 20 years, it has been established as the predominant sperm oocyte-activating factor. PLCZ1 cRNA expression or direct protein microinjection ...
