Browsing by Author "Rachid, Ousama"
Now showing items 1-9 of 9
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Can we use normal saline stored under stress conditions? A simulated prehospital emergency medical setting
( Elsevier Ltd , 2023 , Article)Background: Data on stability and suitability to use normal saline stored under stress conditions in ambulances is lacking. Objective: We aimed to study the impact of exposure to extreme temperature variations on normal ... -
Comprehensive evaluation of the pharmacological and toxicological effects of γ-valerolactone as compared to γ-hydroxybutyric acid: Insights from in vivo and in silico models
( Elsevier , 2023 , Article)Γ-valerolactone (GVL), marketed online as “Tranquilli-G” and “excellent Valium”, is used as a legal substitute for γ-hydroxybutyric acid (GHB); however, until now, GVL has only been connected to one Drug-Facilitated Sexual ... -
The Impact of Pamam Dendrimers on Her2-Positive Breast Cancer and the Early Stages of Embryogenesis
(2020 , Master Thesis)Poly (amidoamine) (PAMAM) dendrimers are widely used in drug delivery systems and gene transfection as drug carriers. They also exert several biological effects including modulating gene expression and interfering with ... -
Pharmaco-toxicological effects of the novel tryptamine hallucinogen 5-MeO-MiPT on motor, sensorimotor, physiological, and cardiorespiratory parameters in mice—from a human poisoning case to the preclinical evidence
( Springer Nature , 2024 , Article)Rationale: The 5-methoxy-N-methyl-N-isopropyltryptamine (5-MeO-MiPT, known online as “Moxy”) is a new psychedelic tryptamine first identified on Italian national territory in 2014. Its hallucinogen effects are broadly ... -
Rivaroxaban Pharmacokinetics in Obese Subjects: A Systematic Review
( Springer Nature , 2022 , Article)Venous thromboembolism (VTE) is a leading cause of morbidity and mortality globally. The direct oral anticoagulants, including rivaroxaban, are relatively novel therapeutic options in the treatment and prevention of VTE. ... -
Strengthening the Quality of Clinical Pharmacokinetic Studies: Development and Validation of a Critical Appraisal Tool For Clinical Pharmacokinetic Research
(2020 , Master Thesis)Background: Critical appraisal process is central to the practice of evidence-based medicine that aids in assessing the quality of the published scientific knowledge. To our knowledge, there is no critical appraisal ... -
The synthetic cathinones MDPHP and MDPV: Comparison of the acute effects in mice, in silico ADMET profiles and clinical reports
( Elsevier , 2024 , Article)The 3,4-methylenedioxy-alpha-pyrrolidinohexanophenone (MDPHP) is a synthetic cathinone closely related to 3,4-methylenedioxypyrovalerone (MDPV), one of the most common synthetic cathinones present in the “bath salts”. MDPHP ... -
The use of a modified Delphi technique to develop a critical appraisal tool for clinical pharmacokinetic studies.
( Springer , 2022 , Article)Critical appraisal aids in assessing the quality of scientific literature, which is central to the practice of evidence-based medicine. Several tools and guidelines are available for critiquing and assessing the quality ... -
Utilization of the Transparent Peer Review Policy to Train Graduate Pharmacy Students on Scientific Critique
( Elsevier , 2024 , Article)ObjectiveRecognizing the importance of training graduate students in scientific critique and peer review, we introduced an innovative instructional strategy using the transparent peer review policy (TPRP). This study aimed ...
