Browsing by Author "Kashir, Junaid"
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Advancing male age differentially alters levels and localization patterns of PLCzeta in sperm and testes from different mouse strains
Kashir, Junaid; Mistry, Bhavesh; Gumssani, Maha; Rajab, Muhammad; Abu-Dawas, Reema; Almohanna, Falah; Nomikos, Michail; Jones, Celine; Abu-Dawud, Raed; Al-Yacoub, Nadya; Coward, Kevin; Lai, F.; Assiri, Abdullah... more authors ... less authors ( Medknow Publications , 2021 , Article)Sperm-specific phospholipase C zeta (PLC) initiates intracellular calcium (Ca2+) transients which drive a series of concurrent events collectively termed oocyte activation. Numerous investigations have linked abrogation ... -
Antigen Unmasking Is Required to Clinically Assess Levels and Localisation Patterns of Phospholipase C Zeta in Human Sperm
Kashir, Junaid; Mistry, Bhavesh V.; BuSaleh, Lujain; Nomikos, Michail; Almuqayyil, Sarah; Abu-Dawud, Raed; AlYacoub, Nadya; Hamdan, Hamdan; AlHassan, Saad; Lai, F. Anthony; Assiri, Abdullah M.; Coskun, Serdar... more authors ... less authors ( MDPI , 2023 , Article)Mammalian oocyte activation is initiated by intracellular calcium (Ca2+) oscillations, driven by the testis-specific phospholipase C zeta (PLCζ). Sperm PLCζ analysis represents a diagnostic measure of sperm fertilisation ... -
Editorial: The role of calcium signaling in gametogenesis and early embryogenesis
Kashir, Junaid; Lai, F. Anthony; Nomikos, Michail ( Frontiers Media , 2022 , Article)Calcium homeostasis exerts a profound role in determining the quality of gametogenesis, the resultant efficacy of fertilisation and ultimately the competency of embryogenesis. Perhaps no other single ion plays such a ...