Browsing by Author "Smith, Adrian"
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Calmodulin Mutations Associated with Congenital Cardiac Disease Display Novel Biophysical and Biochemical Characteristics
Nomikos, Michail; Thanassoulas, Angelos; L. Calver, Brian; Beck, Konrad; Vassilakopoulou, Vyronia; Buntwal, Luke; Konotgianni, Iris; Smith, Adrian; Safieh-Garabedian, Bared; Livaniou, Evangelia; Steen Toft, Egon; Nounesis, George... more authors ... less authors ( Elsevier , 2018 , Article)Calmodulin (CaM) is a cytoplasmic multifunctional calcium (Ca2+)-binding messenger that interacts with the cardiac ryanodine receptor (RyR2), a large transmembrane Ca2+ channel that mediates Ca2+ release from the sarcoplasmic ... -
Life-threatening arrhythmogenic CaM mutations disrupt CaM binding to a distinct RyR2 CaM-binding pocket
Angelos, Thanassoulas; Vassilakopoulou, Vyronia; Calver, Brian L.; Buntwal, Luke; Smith, Adrian; Lai, Christopher; Kontogianni, Iris; Livaniou, Evangelia; Nounesis, George; Lai, F. Anthony; Nomikos, Michail... more authors ... less authors ( Elsevier , 2023 , Article)Calmodulin (CaM) modulates the activity of several proteins that play a key role in excitation-contraction coupling (ECC). In cardiac muscle, the major binding partner of CaM is the type-2 ryanodine receptor (RyR2) and ...