Browsing by Author "El-Gamal, Heba"
Now showing items 1-7 of 7
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Aldose Reductase as a Drug Target for Treatment of Diabetic Nephropathy: Promises and Challenges.
El Gamal, Heba; Munusamy, Shankar ( Bentham Science Publishers , 2017 , Article)Diabetic nephropathy (DN) is one of the most serious microvascular complications of diabetes mellitus and the leading cause of end stage renal disease. One of the key pathways activated in DN is the polyol pathway, in which ... -
Circulating microparticles as biomarkers of stroke: A focus on the value of endothelial- and platelet-derived microparticles.
El-Gamal, Heba; Parray, Aijaz S; Mir, Fayaz A; Shuaib, Ashfaq; Agouni, Abdelali ( Wiley , 2019 , Article)Stroke is one of the leading causes of mortality and disability worldwide. Numerous pathophysiological mechanisms involving blood vessels, coagulation and inflammation contribute to the vascular occlusion. Perturbations ... -
Corrigendum: Renoprotective Effects of Aldose Reductase Inhibitor Epalrestat against High Glucose-Induced Cellular Injury (BioMed Research International (2017) 2017 (5903105) DOI: 10.1155/2017/5903105)
El Gamal, Heba; Eid, Ali Hussein; Munusamy, Shankar ( Hindawi Limited , 2019 , Other)Following publication of the article, Renoprotective Effects of Aldose Reductase Inhibitor Epalrestat against High Glucose-Induced Cellular Injury, the authors were made aware that the effects of epalrestat on the high ... -
Endoplasmic Reticulum (ER) Stress-Generated Extracellular Vesicles (Microparticles) Self-Perpetuate ER Stress and Mediate Endothelial Cell Dysfunction Independently of Cell Survival.
Osman, Aisha; El-Gamal, Heba; Pasha, Mazhar; Zeidan, Asad; Korashy, Hesham M; Abdelsalam, Shahenda S; Hasan, Maram; Benameur, Tarek; Agouni, Abdelali... more authors ... less authors ( Frontiers Media , 2020 , Article)Circulating extracellular vesicles (EVs) are recognized as biomarkers and effectors of endothelial dysfunction, the initiating step of cardiovascular abnormalities. Among these EVs, microparticles (MPs) are vesicles directly ... -
Renoprotective Effects of Aldose Reductase Inhibitor Epalrestat against High Glucose-Induced Cellular Injury
El Gamal, Heba; Eid, Ali Hussein; Munusamy, Shankar ( Hindawi , 2017 , Article)Diabetic nephropathy (DN) is the leading cause of end stage renal disease worldwide. Increased glucose flux into the aldose reductase (AR) pathway during diabetes was reported to exert deleterious effects on the kidney. ... -
Sestrin2 suppression aggravates oxidative stress and apoptosis in endothelial cells subjected to pharmacologically induced endoplasmic reticulum stress
Fatima, Munazza T; Hasan, Maram; Abdelsalam, Shahenda S; Sivaraman, Siveen K; El-Gamal, Heba; Zahid, Muhammad A; Elrayess, Mohamed A; Korashy, Hesham M; Zeidan, Asad; Parray, Aijaz S; Agouni, Abdelali... more authors ... less authors ( Elsevier , 2021 , Article)Endoplasmic reticulum (ER) stress is an inflammatory response that contributes to endothelial dysfunction, a hallmark of cardiovascular diseases, in close interplay with oxidative stress. Recently, Sestrin2 (SESN2) emerged ... -
STANDARDIZATION OF AN IN VITRO MODEL OF DIABETIC NEPHROPATHY IN RENAL TUBULAR CELLS AND INVESTIGATION OF THE ROLE OF ALDOSE REDUCTASE PATHWAY IN HIGH GLUCOSE-INDUCED RENAL CELL INJURY
El Gamal, Heba (2015 , Master Thesis)Diabetic nephropathy (DN) is the leading cause of end stage renal disease, and one of the most serious microvascular complications of diabetes mellitus. Increase in the shift of glucose into the aldose reductase pathway ...