تصفح حسب المؤلف "Ouhtit, Allal"
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Profile of Mental and Behavioral Disorders Among Preschoolers in a Tertiary Care Hospital in Oman: A Retrospective Study
Al-Sharbati, Marwan M.; Al-Farsi, Yahya M.; Al-Sharbati, Zena M.; Al-Sulaimani, Fatima; Ouhtit, Allal; Al-Adawi, Samir... more authors ... less authors ( Oman Medical Specialty Board , 2016 , Article)Objectives Early diagnosis and prompt treatment of mental and behavioral disorders in preschoolers is critical for a better prognosis, ultimately leading to improved quality of life for both the child and the family. ... -
Severe neurological manifestations in an Egyptian patient with a novel frameshift mutation in the Glutaryl-CoA dehydrogenase gene
Moseilhy, Ahmed; Hassan, Magdy M.; El Abd, Heba S. A.; Mohammad, Shaimaa A.; El Bekay, Rajaa; Abdel-Motal, Ussama M.; Ouhtit, Allal; Zaki, Osama K.; Zayed, Hatem... more authors ... less authors ( Springer US , 2016 , Article)Abstract To characterize an Egyptian patient with glutaric acidemia type I (GA I) and to identify the causative mutation( s) that may be responsible for the disease phenotype. MRI was performed on the patient using the ... -
SIRT1, a novel transcriptional downstream target of CD44, linking its deacetylase activity to tumor cell invasion/metastasis
Ahmad, Salma M. S.; Al-Mansoob, Maryam; Ouhtit, Allal ( Frontiers Media S.A. , 2022 , Short Survey)Our tetracycline-off-inducible CD44 expression system previously established in mouse model, revealed that activation of CD44 with its major ligand hyaluronan (HA) promoted breast cancer (BC) metastasis to the liver. To ... -
SOD2, a Potential Transcriptional Target Underpinning CD44-Promoted Breast Cancer Progression
Alateyah, Nouralhuda; Gupta, Ishita; Rusyniak, Radoslaw Stefan; Ouhtit, Allal ( MDPI , 2022 , Article Review)CD44, a cell-adhesion molecule has a dual role in tumor growth and progression; it acts as a tumor suppressor as well as a tumor promoter. In our previous work, we developed a tetracycline-off regulated expression of CD44’s ... -
The power of phytochemicals combination in cancer chemoprevention
Rizeq, Balsam; Gupta, Ishita; Ilesanmi, Josephine; AlSafran, Mohammed; Rahman, MD Mizanur; Ouhtit, Allal... more authors ... less authors ( Ivyspring International Publisher , 2020 , Article Review)Conventional therapies for cancer treatment have posed many challenges, including toxicity, multidrug resistance and economic expenses. In contrast, complementary alternative medicine (CAM), employing phytochemicals have ... -
Towards understanding the genetics of Autism
Shailesh, Harshita; Gupta, Ishita; Sif, Said; Ouhtit, Allal ( Frontiers in Bioscience , 2016 , Article Review)Autism spectrum disorder (ASD) includes a group of neurodevelopmental disorders that affect communication skills, social interaction and intellectual ability. Despite evidence suggesting a strong genetic link with ASD, the ... -
Towards understanding the mechanisms of actions of carcinoembryonic antigen-related cell adhesion molecule 6 in cancer progression
Rizeq, Balsam; Zakaria, Zain; Ouhtit, Allal ( Wiley Open Access , 2017 , Article Review)Human carcinoembryonic antigen (CEA) is the prototypic member of a family of highly related cell surface glycoproteins that includes carcinoembryonic antigenrelated cell adhesion molecule 6 (CEACAM6) and others. CEACAM6 ... -
Validation of Novel Transcriptional Targets that Underpin CD44-promoted breast cancer cell invasion
Ahmad, Salma; Nazar, Hanan; Alatieh, Nouralhuda; Al-Mansoob, Maryam; Farooq, Zainab; Yusuf, Muna; Ouhtit, Allal... more authors ... less authors ( Qatar University Press , 2021 , Poster)Introduction: Breast cancer (BC) is the most common cancer worldwide, and metastasis is its worst aspect and the first cause of death. Metastasis is a multistep process, where an invasion is a recurring event. The process ...