Browsing by Author "Ouhtit, Allal"
Now showing items 1-20 of 30
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Accredited genetic testing in the Arab Gulf region: reinventing the wheel.
( Nature Publishing Group , 2016 , Article)Accredited genetic testing in the Arab Gulf region: reinventing the wheel. -
Anti-cancer properties of Microalgae (T1) Extract in Breast Cancer Cell Lines
( Qatar University Press , 2021 , Poster)Breast cancer (BC), a worldwide health issue, is the most common malignant cancer in women in Gulf region, including the State of Qatar. Unfortunately, malignant tumors has the capability to metastasis, which involves both ... -
Antibody-Dependent Enhancement (ADE) and the role of complement system in disease pathogenesis
( Elsevier Ltd , 2022 , Article Review)Antibody-dependent enhancement (ADE) has been associated with severe disease outcomes in several viral infections, including respiratory infections. In vitro and in vivo studies showed that antibody-response to SARS-CoV ... -
Antibody-dependent enhancement (ADE) of SARS-CoV-2 in patients exposed to MERS-CoV and SARS-CoV-2 antigens
( Wiley , 2024 , Article)This study evaluated the potential for antibody-dependent enhancement (ADE) in serum samples from patients exposed to Middle East respiratory syndrome coronavirus (MERS-CoV). Furthermore, we evaluated the effect of severe ... -
Antibody-dependent enhancement of SARS-CoV-2, the impact of variants and vaccination
( Taylor and Francis Group , 2025 , Article)This study characterized antibody-dependent enhancement (ADE) in serum samples from individuals exposed to SARS-CoV-2 via infection or vaccination and evaluated its association with SARS-CoV-2 variants (Wuhan and Omicron), ... -
ANTIMICROBIAL AND CYTOTOXIC ACTIVITIES OF SELECTED QATARI FLORA
(2018 , Master Thesis)Conventional medicine has been challenged by various issues, including drug resistance and safety. On the other hand, Complementary Alternative Medicine has been increasingly gaining the interest of the scientific community ... -
An Arab registry for type 1 diabetes: global benefits for type 1 diabetes patients
( Taylor & Francis , 2016 , Article)BACKGROUND: The Arab world encompasses twenty-two Arabic-speaking countries, where the rate of consanguinity can exceed 50%. Type 1 diabetes (T1D), a chronic disorder that requires lifelong treatment, is believed to be ... -
Burden and disease pathogenesis of influenza and other respiratory viruses in diabetic patients
( Elsevier , 2022 , Article Review)Over the past two decades, diabetes mellitus (DM) has been receiving increasing attention among autoimmune diseases. The prevalence of type 1 and type 2 diabetes has increased rapidly and has become one of the leading ... -
CD146, a novel target of CD44-signaling, suppresses breast tumor cell invasion.
(2017 , Article)We have previously validated three novel CD44-downstream positively regulated transcriptional targets, including Cortactin, Survivin and TGF-β2, and further characterized the players underlying their separate signaling ... -
CD44 mediates stem cell mobilization to damaged lung via its novel transcriptional targets, Cortactin and Survivin
( Ivyspring International Publisher , 2020 , Article)Beyond their role in bone and lung homeostasis, mesenchymal stem cells (MSCs) are becoming popular in cell therapy. Various insults may disrupt the repair mechanisms involving MSCs. One such insult is smoking, which is a ... -
Docosahexaenoic Acid, a Key Compound for Enhancing Sensitization to Drug in Doxorubicin-Resistant MCF-7 Cell Line.
( MDPI , 2023 , Article)Drug resistance is a well-known and significant obstacle in the battle against cancer, rendering chemotherapy treatments often ineffective. To improve the effectiveness of chemotherapy, researchers are exploring the use ... -
Haematococcus pluvialis Microalgae Extract Inhibits Proliferation, Invasion, and Induces Apoptosis in Breast Cancer Cells
( Frontiers Media S.A. , 2022 , Article)Breast cancer (BC) is the most common malignant cancer in females worldwide. Drug resistance, toxicity, and the failure of current therapies to completely cure BC has challenged conventional medicine. Consequently, ... -
Influenza prevalence and vaccine efficacy among diabetic patients in Qatar
( Elsevier , 2023 , Article)Seasonal influenza viruses may lead to severe illness and mortality in patients with comorbidities, including Diabetes Mellitus (DM). Vaccination against influenza in DM patients may reduce influenza incidence and severity. ... -
Inositol 1,4,5-Trisphosphate Receptors in Hypertension.
( Frontiers Media , 2018 , Article Review)Chronic hypertension remains a major cause of global mortality and morbidity. It is a complex disease that is the clinical manifestation of multiple genetic, environmental, nutritional, hormonal, and aging-related disorders. ... -
KYNU, a novel potential target that underpins CD44-promoted breast tumour cell invasion
( Blackwell Publishing Inc. , 2021 , Article Review)Using a validated tetracycline-off-inducible CD44 expression system in mouse model, we have previously demonstrated that the hyaluronan (HA) receptor CD44 promotes breast cancer (BC) metastasis to the liver. To unravel the ... -
Molecular Evidence of Anticancer Activity of Camel Milk Combined with Camel Urine
( Austin Publishing Group , 2021 , Article)Camel Milk (CM) and Camel Urine (CU) is a traditional practice in the Middle East and other countries as an alternative treatment against cancer. We hypothesized that a combination of CM and CU (CM+CU), used at ... -
Molecular Evidence of Breast Cancer Cell Proliferation Inhibition by a Combination of Selected Qatari Medicinal Plants Crude Extracts
( MDPI , 2023 , Article): Breast cancer (BC) is the most common malignancy, and conventional medicine has failed to establish efficient treatment modalities. Conventional medicine failed due to lack of knowledge of the mechanisms that underpin ... -
Novel CD44-downstream signaling pathways mediating breast tumor invasion
( Ivyspring International Publisher , 2018 , Article Review)CD44, also known as homing cell adhesion molecule is a multi-structural cell molecule involved in cell-cell and cell-extracellular matrix communications. CD44 regulates a number of central signaling pathways, including ... -
Novel role of BRCA1 interacting C-terminal helicase 1 (BRIP1) in breast tumour cell invasion
( Wiley Open Access , 2020 , Article)Breast cancer (BC) is the most common malignancy and the leading cause of death in women worldwide. Only 5%-10% of mutations in BRCA genes are associated with familial breast tumours in Eastern countries, suggesting the ... -
The Novel Role of BRIP1 in Breast Tumor Development and Progression
(2020 , Dissertation)Breast cancer (BC) is the most common malignancy and the leading cause of death in women worldwide. Only 5-10% of mutations in the BRCA genes are attributed to familial breast tumors in Eastern countries, suggesting the ...
