Browsing by Author "Martínez-Cruz, Luis Alfonso"

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The disease-linked R336C mutation in cystathionine β-synthase disrupts communication with the PLP cofactor, yet maintains the enzyme's overall structural integrity

Conter, Carolina; Núñez-Franco, Reyes; Al-Sadeq, Duaa Walid; Fernández-Rodríguez, Carmen; Goikoetxea-Usandizaga, Naroa; Nasrallah, Gheyath K.; Nomikos, Michail; Martinez-Chantar, Maria Luz; Astegno, Alessandra; Jiménez-Osés, Gonzalo; Martínez-Cruz, Luis Alfonso... more authors ... less authors ( John Wiley & Sons , 2025 , Article)
Cystathionine β-synthase (CBS) is a pyridoxal-phosphate (PLP)-dependent enzyme essential for the reverse transsulfuration pathway, where homocysteine and serine combine to form cystathionine, the immediate precursor of ...