Browsing by Author "Prabhu, Kirti"
Now showing items 1-6 of 6
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Epigenetic and breast cancer therapy: Promising diagnostic and therapeutic applications.
Sher, Gulab; Salman, Nadia Aziz; Khan, Abdul Q; Prabhu, Kirti S; Raza, Afsheen; Kulinski, Michal; Dermime, Said; Haris, Mohammad; Junejo, Kulsoom; Uddin, Shahab... more authors ... less authors ( Elsevier , 2020 , Article Review)The global burden of breast cancer (BC) is increasing significantly. This trend is caused by several factors such as late diagnosis, limited treatment options for certain BC subtypes, drug resistance which all lead to poor ... -
The Role of Extracellular Vesicles as Modulators of the Tumor Microenvironment, Metastasis and Drug Resistance in Colorectal Cancer.
Siveen, Kodappully S; Raza, Afsheen; Ahmed, Eiman I; Khan, Abdul Q; Prabhu, Kirti S; Kuttikrishnan, Shilpa; Mateo, Jericha M; Zayed, Hatem; Rasul, Kakil; Azizi, Fouad; Dermime, Said; Steinhoff, Martin; Uddin, Shahab... more authors ... less authors ( MDPI , 2019 , Article)Colorectal cancer (CRC) is one of the most common cancers worldwide, with high morbidity and mortality rates. A number of factors including modulation of the tumor microenvironment, high metastatic capability, and resistance ... -
Role of non-coding RNA networks in leukemia progression, metastasis and drug resistance.
Bhat, Ajaz A; Younes, Salma N; Raza, Syed Shadab; Zarif, Lubna; Nisar, Sabah; Ahmed, Ikhlak; Mir, Rashid; Kumar, Sachin; Sharawat, Surender K; Hashem, Sheema; Elfaki, Imadeldin; Kulinski, Michal; Kuttikrishnan, Shilpa; Prabhu, Kirti S; Khan, Abdul Q; Yadav, Santosh K; El-Rifai, Wael; Zargar, Mohammad A; Zayed, Hatem; Haris, Mohammad; Uddin, Shahab... more authors ... less authors ( BMC , 2020 , Article Review)Early-stage detection of leukemia is a critical determinant for successful treatment of the disease and can increase the survival rate of leukemia patients. The factors limiting the current screening approaches to leukemia ... -
Sanguinarine Induces Apoptosis in Papillary Thyroid Cancer Cells via Generation of Reactive Oxygen Species.
Khan, Abdul Q; Mohamed, Elham A N; Hakeem, Ishrat; Nazeer, Aneeza; Kuttikrishnan, Shilpa; Prabhu, Kirti S; Siveen, Kodappully S; Nawaz, Zafar; Ahmad, Aamir; Zayed, Hatem; Uddin, Shahab... more authors ... less authors ( MDPI , 2020 , Article)Sanguinarine (SNG), a natural compound with an array of pharmacological activities, has promising therapeutic potential against a number of pathological conditions, including malignancies. In the present study, we have ... -
Sanguinarine Induces Apoptosis Pathway in Multiple Myeloma Cell Lines via Inhibition of the JaK2/STAT3 Signaling.
Akhtar, Sabah; Achkar, Iman W; Siveen, Kodappully S; Kuttikrishnan, Shilpa; Prabhu, Kirti S; Khan, Abdul Q; Ahmed, Eiman I; Sahir, Fairooz; Jerobin, Jayakumar; Raza, Afsheen; Merhi, Maysaloun; Elsabah, Hesham M; Taha, Ruba; Omri, Halima El; Zayed, Hatem; Dermime, Said; Steinhoff, Martin; Uddin, Shahab... more authors ... less authors ( Frontiers Media , 2019 , Article)Sanguinarine (SNG), a benzophenanthridine alkaloid, has displayed various anticancer abilities in several vivo and studies. However, the anticancer potential of SNG is yet to be established in multiple myeloma (MM), a ... -
Vascular endothelial growth factor (VEGF) signaling in tumour vascularization: Potential and challenges
Siveen, Kodappully Sivaraman; Prabhu, Kirti; Krishnankutty, Roopesh; Kuttikrishnan, Shilpa; Tsakou, Magdalini; Alali, Feras Q.; Dermime, Said; Mohammad, Ramzi M.; Uddin, Shahab... more authors ... less authors ( Bentham , 2017 , Article)Angiogenesis is defined as the physiological process by which new blood vessels develop from pre-existing vessels; either by sprouting or intussusception. Inhibition of angiogenesis is one of the most encouraging strategies ...