Browsing by Author "Souchelnytskyi, Serhiy"
Now showing items 1-18 of 18
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Acquisition of invasiveness by breast adenocarcinoma cells engages established hallmarks and novel regulatory mechanisms
( International Institute of Anticancer Research , 2019 , Article)Background/Aim: Proteomics of invasiveness opens a window on the complexity of the metastasis-engaged mechanisms. The extend and types of this complexity require elucidation. Materials and Methods: Proteomics, immuno ... -
Breast carcinoma metastasis suppressor gene 1 (BRMS1): update on its role as the suppressor of cancer metastases.
( Springer , 2015 , Article)BRMS1 was discovered over a decade ago as a potential tumor suppressor gene. In this review, we summarize the recent findings about the structure of BRMS1, mechanisms of its action and a role of BRMS1 in the cancer ... -
COVID-19 engages clinical markers for the management of cancer and cancer-relevant regulators of cell proliferation, death, migration, and immune response
( Nature Research , 2021 , Article)Clinical reports show that the management of cancer patients infected with SARS-CoV-2 requires modifications. Understanding of cancer-relevant mechanisms engaged by the virus is essential for the evidence-based management ... -
Exposure to EGF and 17β‑estradiol irreversibly affects the proliferation and transformation of MCF7 cells but is not sufficient to promote tumor growth in a xenograft mouse model upon withdrawal of exposure.
( Spandidos Publications , 2018 , Article)Epidermal growth factor (EGF) and estrogen are potent regulators of breast tumorigenesis. Their short‑term actions on human breast epithelial cells have been investigated extensively. However, the consequence of a long‑term ... -
The Exposure to Human Breast Cancer Cells Altered 14 Post-Translational Modifications of Human Serum Albumin.
( International Federation of Clinical Chemistry and Laboratory Medicine , 2022 , Article)Serum albumin is in contact with practically all cells in the human body, including tumor cells in cancer patients. The purpose of this study was to explore whether cancer cells affect post-translational modifications ... -
Glycosylation is a novel TGF?1-independent post-translational modification of Smad2
( Elsevier B.V. , 2019 , Article)Smad2 is a crucial component of intracellular signaling by transforming growth factor-? (TGF?). Here we describe that Smad2 is glycosylated, which is a novel for Smad2 post-translational modification. We showed that the ... -
Identification of a 48 kDa form of unconventional myosin 1c in blood serum of patients with autoimmune diseases.
( Elsevier , 2016 , Article)We searched for protein markers present in blood serum of multiple sclerosis (MS), rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) patients in comparison to healthy human individuals. We used precipitati ... -
Identification of SER-PRO-CYS Peptide in Blood Serum of Multiple Sclerosis Patients
( Bentham Science Publishers , 2016 , Article)Monitoring of multiple sclerosis (MS) requires additional molecular markers. Recently, we used original TCA-precipitation/extraction approach in combination with MALDI TOF/TOF mass-spectrometry and identified earlier unknown ... -
Isolation and identification in human blood serum of the proteins possessing the ability to bind with 48 kDa form of unconventional myosin 1c and their possible diagnostic and prognostic value
( Wiley , 2021 , Article)We firstly identified 48 kDa molecular form of the unconventional myosin 1c (p48/Myo1C), and isolated it from blood serum of multiple sclerosis patients. The amount of p48/Myo1C in human blood serum correlated with some ... -
Novel Post-translational Modifications in Human Serum Albumin
( Bentham , 2022 , Article)Aim: This study aims to identify novel post-translational modifications in human serum albumin by mass spectrometry. Background: Serum albumin is the most abundant protein in plasma, has many physiological functions, and ... -
Progress and challenges in the proteomics of domestic pig in research on the female reproductive system
( Polish Society Magnesium Research , 2016 , Article)The proteomics of pigs is developing dynamically, attracting much attention among representatives of medical and health sciences, veterinary medicine, agricultural and natural sciences. The pig has been widely studied in ... -
Proteomic analysis of T. qataranse exposed to lead (Pb) stress reveal new proteins with potential roles in Pb tolerance and detoxification mechanism
( Frontiers Media , 2022 , Article)Soil lead (Pb) contamination is one of the environmental problems facing the modern world. Sources of Pb in soil include industrial activities such as mining and smelting processes, agricultural activities such as application ... -
Proteomic analysis of the endometrium during early pregnancy in the domestic pig.
( CSIRO Publishing , 2017 , Article)Reproductive processes in domestic pigs have been studied extensively. Pigs are one of the main sources of meat for human consumption and are an established model for investigations into mammalian, including human, ... -
Proteomic profile alterations in porcine conceptuses during early stages of development
( Elsevier , 2021 , Article)The dynamic embryo development during the early stages of gestation requires precise molecular changes, including proteomic ones. We aimed to find unique proteins for porcine conceptuses specifically during the peri-implantation ... -
Proteomic Profiling of Diffuse Large B-Cell Lymphomas
( Karger Publishers , 2018 , Article)The aim of this study was to identify differences in proteome profiles of diffuse large B-cell lymphoma (DLBCL) of nongerminal center (non-GC) versus GC type in the search for new markers and drug targets. Six DLBCL, with ... -
Review of Post-translational Modification of Human Serum Albumin
( Bentham , 2022 , Article)Post-translational modifications (PTMs) may affect the functions of human serum albumin. Here we review reports of novel PTMs of human serum albumin. This study reviewed one hundred twenty-three recently reported novel ... -
Systemic properties of carcinogenesis: lessons from studies on the Earth and in the Space
( Qatar University Press , 2020 , Poster)Background: Hundreds of proteins and genes are involved in initiation and growth of tumors. These proteins and genes act in coordinated ways, and their relations are visualized as networks. Networks are more accurate ... -
Targeted and systemic insights into the crosstalk between DNA-dependent protein kinase catalytic subunit and receptors of estrogen, progesterone and epidermal growth factor in the context of cancer
( Springer , 2021 , Article)DNA-dependent protein kinase catalytic subunit (DNA-PKcs) has emerged as a regulator of carcinogenesis. Increased expression of DNA-PKcs correlates with metastatic cancers. Here we review recently reported crosstalk of ...
