تصفح حسب المؤلف "Munusamy, Shankar"
-
Aldose Reductase as a Drug Target for Treatment of Diabetic Nephropathy: Promises and Challenges.
El Gamal, Heba; Munusamy, Shankar ( Bentham Science Publishers , 2017 , Article)Diabetic nephropathy (DN) is one of the most serious microvascular complications of diabetes mellitus and the leading cause of end stage renal disease. One of the key pathways activated in DN is the polyol pathway, in which ... -
Metformin Attenuates Albumin-induced Alterations in Renal Tubular Cells In Vitro
Allouch, Soumaya; Munusamy, Shankar ( Wiley Periodicals, Inc , 2017 , Article)Proteinuria (albuminuria) plays a crucial role in the etiology of chronic kidney disease (CKD) via alteration of multiple signaling pathways and cellular process in renal cells. The objectives of this study are to investigate ... -
Nephroprotective Effects of Metformin in Diabetic Nephropathy
Ravindran, Sreenithya; Kuruvilla, Vinitha; Wilbur, Kerry; Munusamy, Shankar ( Wiley , 2017 , Article)Metformin, a well-known anti-diabetic agent, is very effective in lowering blood glucose in patients with type 2 diabetes with minimal side-effects. Metformin is also being recommended in the treatment of obesity and ... -
Obesity-induced changes in kidney mitochondria and endoplasmic reticulum in the presence or absence of leptin
Munusamy, Shankar; do Carmo, Jussara M.; Hosler, Jonathan P.; Hall, John E. ( American Physiological Society , 2015 , Article)We investigated obesity-induced changes in kidney lipid accumulation, mitochondrial function, and endoplasmic reticulum (ER) stress in the absence of hypertension, and the potential role of leptin in modulating these ... -
PROTECTIVE EFFECTS OF METFORMIN IN AN IN VITRO MODEL OF PROTEINURIC KIDNEY DISEASE
Allouch, Soumaya (2017 , Master Thesis)Albuminuria, a hallmark of chronic kidney disease (CKD), plays a crucial role in the etiology of CKD. High albumin levels are thought to induce endoplasmic reticulum (ER) stress and activate the AKT pathway, and lead to ... -
Renoprotective Effects of Aldose Reductase Inhibitor Epalrestat against High Glucose-Induced Cellular Injury
El Gamal, Heba; Eid, Ali Hussein; Munusamy, Shankar ( Hindawi , 2017 , Article)Diabetic nephropathy (DN) is the leading cause of end stage renal disease worldwide. Increased glucose flux into the aldose reductase (AR) pathway during diabetes was reported to exert deleterious effects on the kidney. ... -
Sestrin2 as a Novel Biomarker and Therapeutic Target for Various Diseases
Pasha, Mazhar; Eid, Ali H.; Eid, Assaad A.; Gorin, Yves; Munusamy, Shankar ( Hindawi , 2017 , Article)Sestrin2 (SESN2), a highly conserved stress-inducible metabolic protein, is known to repress reactive oxygen species (ROS) and provide cytoprotection against various noxious stimuli including genotoxic and oxidative stress, ... -
STANDARDIZATION OF AN IN VITRO MODEL OF DIABETIC NEPHROPATHY IN RENAL TUBULAR CELLS AND INVESTIGATION OF THE ROLE OF ALDOSE REDUCTASE PATHWAY IN HIGH GLUCOSE-INDUCED RENAL CELL INJURY
El Gamal, Heba (2015 , Master Thesis)Diabetic nephropathy (DN) is the leading cause of end stage renal disease, and one of the most serious microvascular complications of diabetes mellitus. Increase in the shift of glucose into the aldose reductase pathway ... -
Structure–activity relationship of piperine and its synthetic amide analogs for therapeutic potential to prevent experimentally induced ER stress in vitro
Hammad, Ayat S.; Ravindran, Sreenithya; Khalil, Ashraf; Munusamy, Shankar ( Springer Netherlands , 2017 , Article)Endoplasmic reticulum (ER) is the key organelle involved in protein folding and maturation. Emerging studies implicate the role of ER stress in the development of chronic kidney disease. Thus, there is an urgent need for ... -
Synthesis and Pharmacological Evaluation of Different Piperine Analogs for Therapeutic Potential to Prevent ER Stress
Hammad, Ayat Samir (2015 , Master Thesis)Background: Endoplasmic reticulum (ER) is the chief organelle involved in protein folding and maturation. Emerging studies implicate the role of ER stress in the development of chronic kidney disease (CKD). Thus, there is ...