Browsing by Author "Albagha, Omar"

Now showing items 1-11 of 11

    • A population study of clinically actionable genetic variation affecting drug response from the Middle East 

      Jithesh, Puthen Veettil; Abuhaliqa, Mohammed; Syed, Najeeb; Ahmed, Ikhlak; El Anbari, Mohammed; ... more authors ( Nature Research , 2022 , Article)
      Clinical implementation of pharmacogenomics will help in personalizing drug prescriptions and alleviate the personal and financial burden due to inefficacy and adverse reactions to drugs. However, such implementation is ...

    • Blood Proteomics Analysis Reveals Potential Biomarkers and Convergent Dysregulated Pathways in Autism Spectrum Disorder: A Pilot Study 

      Mesleh, Areej; Ehtewish, Hanan; de la Fuente, Alberto; Al-shamari, Hawra; Ghazal, Iman; ... more authors ( Multidisciplinary Digital Publishing Institute (MDPI) , 2023 , Article)
      Autism spectrum disorder (ASD) is an umbrella term that encompasses several disabling neurodevelopmental conditions. These conditions are characterized by impaired manifestation in social and communication skills with ...

    • Genome-wide association study identifies several loci for HEV seropositivity 

      Maria K., Smatti; Al-Sarraj, Yasser A.; Albagha, Omar; Yassine, Hadi M. ( Elsevier , 2023 , Article)
      Hepatitis E viral (HEV) infection imposes a heavy global health burden. The variability in the prevalence of serological markers of HEV infection between different ethnic groups proposes a host genetic influence. Here, we ...

    • Genome-Wide Association Study Reveals a Novel Association Between MYBPC3 Gene Polymorphism, Endurance Athlete Status, Aerobic Capacity and Steroid Metabolism. 

      Al-Khelaifi, Fatima; Yousri, Noha A; Diboun, Ilhame; Semenova, Ekaterina A; Kostryukova, Elena S; ... more authors ( Frontiers Media , 2020 , Article)
      The genetic predisposition to elite athletic performance has been a controversial subject due to the underpowered studies and the small effect size of identified genetic variants. The aims of this study were to investigate ...

    • Host genetic variants potentially associated with SARS-CoV-2: A multi-population analysis 

      Smatti, Maria K.; Al-Sarraj, Yasser; Albagha, Omar; Yassine, Hadi M. ( Qatar University Press , 2020 , Poster)
      Background: Clinical outcomes of coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) showed enormous inter-individual and inter-population differences, possibly ...

    • Host Genetic Variants Potentially Associated With SARS-CoV-2: A Multi-Population Analysis. 

      Smatti, Maria K; Al-Sarraj, Yasser A; Albagha, Omar; Yassine, Hadi M ( Frontiers Media , 2020 , Article)
      Clinical outcomes of coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) showed enormous inter-individual and inter-population differences, possibly due to host ...

    • Metabolic GWAS of elite athletes reveals novel genetically-influenced metabolites associated with athletic performance. 

      Al-Khelaifi, Fatima; Diboun, Ilhame; Donati, Francesco; Botre, Francesco; Abraham, David; ... more authors ( Nature Research , 2019 , Article)
      Genetic research of elite athletic performance has been hindered by the complex phenotype and the relatively small effect size of the identified genetic variants. The aims of this study were to identify genetic predisposition ...

    • Metabolomic Profiling of Pregnancies With Polycystic Ovary Syndrome Identifies a Unique Metabolic Signature and Potential Predictive Biomarkers of Low Birth Weight 

      Diboun, Ilhame; Ramanjaneya, Manjunath; Ahmed, Lina; Bashir, Mohammed; Butler, Alexandra E; ... more authors ( Frontiers Media , 2021 , Article)
      Polycystic ovary syndrome (PCOS) is a complex syndrome with clinical features of an endocrine/metabolic disorder. Various metabolites show significant association with PCOS; however, studies comparing the metabolic profile ...

    • Metabolomics of lean/overweight insulin resistant females reveals alterations in steroids and fatty acids. 

      Diboun, Ilhame; Al-Mansoori, Layla; Al-Jaber, Hend; Albagha, Omar; Elrayess, Mohamed A ( Endocrine Society , 2020 , Article)
      The global diabetes epidemic is largely attributed to obesity-triggered metabolic syndrome. However, the impact of insulin resistance (IR) prior to obesity on the high prevalence of diabetes and the molecular mediators ...

    • Predictive Biomarkers of Intensive Care Unit and Mechanical Ventilation Duration in Critically-Ill Coronavirus Disease 2019 Patients. 

      Taleb, Sara; Yassine, Hadi M; Benslimane, Fatiha M; Smatti, Maria K; Schuchardt, Sven; ... more authors ( Frontiers Media , 2021 , Article)
      Detection of early metabolic changes in critically-ill coronavirus disease 2019 (COVID-19) patients under invasive mechanical ventilation (IMV) at the intensive care unit (ICU) could predict recovery patterns and help in ...

    • Qatar genome: Insights on genomics from the Middle East 

      Mbarek, Hamdi; Devadoss Gandhi, Geethanjali; Selvaraj, Senthil; Al-Muftah, Wadha; Badji, Radja; ... more authors ( Wiley , 2022 , Article)
      Despite recent biomedical breakthroughs and large genomic studies growing momentum, the Middle Eastern population, home to over 400 million people, is underrepresented in the human genome variation databases. Here we ...