Browsing by Author "Mohamed, Iman A."
Now showing items 1-4 of 4
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The Efficacy of Etoposide on H9c2 Cardiomyoblasts Against Doxorubicin Induced Cardiotoxicity
Shabana, Sara; Aden, Suad; Abdulrahman, Nabeel; Riaz, Sadaf; Jaballah, Maiy; Mohamed, Iman A.; Mraiche, Fatima... more authors ... less authors ( OMICS International , 2015 , Article)Background: Doxorubicin (DOX), a widely used anticancer drug, has been associated with cardiotoxicity. Recently, DOX-induced cardiotoxicity has been attributed to topoisomerase II (TOPII)-β expression and activity. In our ... -
Na+/H+ exchanger isoform 1 induced osteopontin expression in cardiomyocytes involves NFAT3/Gata4
Mlih, Mohamed; Abdulrahman, Nabeel; Gadeau, Alain-Pierre; Mohamed, Iman A.; Jaballah, Maiy; Mraiche, Fatima... more authors ... less authors ( Springer-Verlag , 2015 , Article)Osteopontin (OPN), a multifunctional glycophosphoprotein, has been reported to contribute to the development and progression of cardiac remodeling and hypertrophy. Cardiac-specific OPN knockout mice were protected against ... -
The Role of Cardiac Myosin Binding Protein C3 in Hypertrophic Cardiomyopathy- Progress and Novel Therapeutic Opportunities
Mohamed, Iman A.; Krishnamoorthy, Navaneethakrishnan T.; Nasrallah, Gheyath K.; Da'as, Sahar ( Wiley , 2016 , Article)Hypertrophic cardiomyopathy (HCM) is a common autosomal dominant genetic cardiovascular disorder marked by genetic and phenotypic heterogeneity. Mutations in the gene encodes the cardiac myosin-binding protein C, cMYBPC3 ... -
Transcriptome Profile Identifies Actin as an Essential Regulator of Cardiac Myosin Binding Protein C3 Hypertrophic Cardiomyopathy in a Zebrafish Model
Da’as, Sahar Isa; Hasan, Waseem; Salem, Rola; Younes, Nadine; Abdelrahman, Doua; Mohamed, Iman A.; Aldaalis, Arwa; Temanni, Ramzi; Mathew, Lisa Sara; Lorenz, Stephan; Yacoub, Magdi; Nomikos, Michail; Nasrallah, Gheyath K.; Fakhro, Khalid A.... more authors ... less authors ( MDPI , 2022 , Article)Variants in cardiac myosin-binding protein C (cMyBP-C) are the leading cause of inherited hypertrophic cardiomyopathy (HCM), demonstrating the key role that cMyBP-C plays in the heart’s contractile machinery. To investigate ...