Browsing by Author "Tkac, Jan"
Now showing items 1-20 of 28
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Analysis of serum glycome by lectin microarrays for prostate cancer patients - a search for aberrant glycoforms
( Springer , 2020 , Article)This is the first work focused on glycoprofiling of whole N- and O- glycome using lectins in an array format applied for analysis of serum samples from healthy individuals, benign prostate hyperplasia (BPH) patients, and ... -
Anisotropy in CNT composite fabricated by combining directional freezing and gamma irradiation of acrylic acid
( Elsevier, Ltd , 2016 , Article)A novel fabrication process for composite consisting of organized modified carbon nanotubes (CNT) in the polyacrylic acid (PAA) matrix has been developed. The CNT were organized along crystallite domains during a directional ... -
Carboxybetaine Ester Feature as a Platform for Switchable Surface Properties
( Hamad bin Khalifa University Press (HBKU Press) , 2016 , Conference)A lot of strategies for smart approaches on surfaces were applied such as hydrogel layer, polymer brushes or self-assembly monolayers (SAM). [1] Nowadays switchable zwitterionic materials consisting of molecules with ... -
Carboxybetaine Modified Interface for Electrochemical Glycoprofiling of Antibodies Isolated from Human Serum
( American Chemical Society , 2015 , Article)Impedimetric lectin biosensors capable of recognizing two different carbohydrates (galactose and sialic acid) in glycans attached to antibodies isolated from human serum were prepared. The first step entailed the modification ... -
Electrochemical Investigation of Interfacial Properties of Ti3C2Tx MXene Modified by Aryldiazonium Betaine Derivatives
( Frontiers Media S.A. , 2020 , Article)For efficient and effective utilization of MXene such as biosensing or advanced applications, interfacial modification of MXene needs to be considered. To this end, we describe modification of Ti3C2Tx MXene by aryldiazonium-based ... -
Electrochemical performance of Ti3C2Tx MXene in aqueous media: towards ultrasensitive H2O2 sensing
( Elsevier Ltd , 2017 , Article)An extensive characterization of pristine and oxidized Ti3C2Tx (T: O, OH, F) MXene showed that exposure of MXene to an anodic potential in the aqueous solution oxidizes the nanomaterial forming TiO2 layer or TiO2 domains ... -
Exchange counterion in polycationic hydrogels: Tunability of hydrophobicity, water state, and floating capability for a floating ph device
( MDPI AG , 2021 , Article)Smart gel materials are capable of controlling and switching swelling, water state, and wettability properties triggered by external stimuli. In this study, we fabricated a series of polyelectrolyte hydrogels bearing a ... -
Glycomics of prostate cancer: updates
( Taylor and Francis Ltd , 2019 , Article)Introduction: Prostate cancer (PCa) is a life-threatening disease affecting millions of men. The current best PCa biomarker (level of prostate-specific antigen in serum) lacks specificity for PCa diagnostics and this is ... -
Glycoprofiling as a novel tool in serological assays of systemic sclerosis: A comparative study with three bioanalytical methods
( Elsevier , 2014 , Article)Systemic sclerosis (SSc) is an autoimmune disease seriously affecting patient’s quality of life. The heterogeneity of the disease also means that identification and subsequent validation of biomarkers of the disease is ... -
Glycoprofiling of cancer biomarkers: Label-free electrochemical lectin-based biosensors
( De Gruyter , 2015 , Article)Glycosylation of biomolecules is one of the most prevalent post- and co-translational modification in a human body, with more than half of all human proteins being glycosylated. Malignant transformation of cells influences ... -
Graphene as a signal amplifier for preparation of ultrasensitive electrochemical biosensors
( Springer-Verlag , 2015 , Article)Early diagnostics of diseases performed with minimal money and time consumption has become achievable due to recent advances in development of biosensors. These devices use biorecognition elements for selective interaction ... -
Highly stable Ti3C2Tx (MXene)/Pt nanoparticles-modified glassy carbon electrode for H2O2 and small molecules sensing applications
( Elsevier B.V. , 2018 , Article)© 2018 Elsevier B.V. Electrochemical performance of a 2D Ti3C2Tx (MXene, where T: [dbnd]O, –OH, –F) sheets modified with Pt nanoparticles (PtNPs) was investigated. The results showed that Ti3C2Tx/PtNP nanocomposite deposited ... -
Immobilization of bilirubin oxidase on graphene oxide flakes with different negative charge density for oxygen reduction. The effect of GO charge density on enzyme coverage, electron transfer rate and current density
( Elsevier Ltd , 2017 , Article)Previously we showed that an effective bilirubin oxidase (BOD)-based biocathode using graphene oxide (GO) could be prepared in 2 steps: 1. electrostatic adsorption of BOD on GO; 2. electrochemical reduction of the BOD-GO ... -
Immobilization of concanavalin A lectin on a reduced graphene oxide-thionine surface by glutaraldehyde crosslinking for the construction of an impedimetric biosensor
( Elsevier B.V. , 2017 , Article)Lectins, which are proteins with selective affinity to glycans or glycoproteins, have been recognized as promising agents for the construction of devices for the detection of specific glycoproteins and for glycoprofiling. ... -
Mixed Zwitterion-Based Self-Assembled Monolayer Interface for Impedimetric Glycomic Analyses of Human IgG Samples in an Array Format
( American Chemical Society , 2016 , Article)An impedimetric lectin biosensor for the detection of changes in the glycan structure of antibodies isolated from human serum is here correlated with the progression of rheumatoid arthritis (RA). The biosensor was built ... -
MXene-based electrochemical devices applied for healthcare applications
( Springer , 2024 , Article Review)The initial part of the review provides an extensive overview about MXenes as novel and exciting 2D nanomaterials describing their basic physico-chemical features, methods of their synthesis, and possible interfacial ... -
Nanomaterial-based biosensors for detection of prostate specific antigen
( Springer-Verlag Wien , 2017 , Article Review)Screening serum for the presence of prostate specific antigen (PSA) belongs to the most common approach for the detection of prostate cancer. This review (with 156 refs.) addresses recent developments in PSA detection based ... -
Nanotechnology in Glycomics: Applications in Diagnostics, Therapy, Imaging, and Separation Processes
( John Wiley and Sons Inc. , 2017 , Article Review)This review comprehensively covers the most recent achievements (from 2013) in the successful integration of nanomaterials in the field of glycomics. The first part of the paper addresses the beneficial properties of ... -
Nicotinamide-based supergelator self-assembling via asymmetric hydrogen bonding NH OC and H Br pattern for reusable, moldable and self-healable nontoxic fuel gels
( Academic Press Inc. , 2021 , Article)Hypothesis Development of highly efficient low-molecular weight gelators (LMWGs) for safe energy storage materials is of great demand. Energy storage materials as fuel gels are often achieved by construction of hybrid ... -
Nicotinamide-based supergelator self-assembling via asymmetric hydrogen bonding NH⋯OC and H⋯Br− pattern for reusable, moldable and self-healable nontoxic fuel gels
( Elsevier , 2021 , Article)Hypothesis Development of highly efficient low-molecular weight gelators (LMWGs) for safe energy storage materials is of great demand. Energy storage materials as fuel gels are often achieved by construction of hybrid ...
