Browsing by Author "Udhaya Kumar, S."
Now showing items 1-5 of 5
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Chapter Four Controlling cell proliferation by targeting cyclin-dependent kinase 6 using drug repurposing approach
( Elsevier , 2023 , Book chapter)Cyclin-dependent kinase 6 (CDK6) is an essential kinase in cell cycle progression, which is a viable target for inhibitors in various malignancies, including breast cancer. This study aimed to virtually screen efficient ... -
Chapter Seven Exploring the effect of disease causing mutations in metal binding sites of human ARSA in metachromatic leukodystrophy
( Elsevier , 2024 , Book chapter)The arylsulfatase A (ARSA) gene is observed to be deficient in patients with metachromatic leukodystrophy (MLD), a type of lysosomal storage disease. MLD is a severe neurodegenerative disorder characterized by an autosomal ... -
Chapter Three Elucidating the mechanism of antimicrobial resistance in Mycobacterium tuberculosis using gene interaction networks
( Elsevier , 2023 , Book chapter)Antimicrobial resistance (AMR) in microorganisms is an urgent global health threat. AMR of Mycobacterium tuberculosis is associated with significant morbidity and mortality. It is of great importance to underpin the ... -
Identification of dysregulated canonical pathways associated with pathogenesis and progression of Amyotrophic Lateral Sclerosis—An integrated bioinformatics approach
( Elsevier , 2023 , Article)The mechanisms responsible for the pathogenesis and progression of Amyotrophic Lateral Sclerosis (ALS) remain poorly understood, making the diagnosis of ALS challenging. We aimed to find the novel gene biomarkers via ... -
Molecular characterization of circadian gene expression and its correlation with survival percentage in colorectal cancer patients
( Elsevier , 2023 , Book chapter)Colorectal cancer (CRC) is a form of cancer characterized by many symptoms and readily metastasizes to different organs in the body. Circadian rhythm is one of the many processes that is observed to be dysregulated in ...