Browsing by Author "Sif, Saïd"
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The Novel Role of BRIP1 in Breast Tumor Development and Progression
RIZEQ, BALSAM RIAD (2020 , Dissertation)Breast cancer (BC) is the most common malignancy and the leading cause of death in women worldwide. Only 5-10% of mutations in the BRCA genes are attributed to familial breast tumors in Eastern countries, suggesting the ... -
Promoter–enhancer looping at the PPARγ2 locus during adipogenic differentiation requires the Prmt5 methyltransferase
LeBlanc, Scott E.; Wu, Qiong; Lamba, Pallavi; Sif, Saïd; Imbalzano, Anthony N. ( Oxford University Press , 2016 , Article)PPARγ2 is a critical lineage-determining transcription factor that is essential for adipogenic differentiation. Here we report characterization of the three-dimensional structure of the PPARγ2 locus after the onset of ... -
Uncovering the Epigenetic Contribution of Protein Arginine Methyltransferase 5 (PRMT5) during Zebrafish Cardiomyogenesis
Zakaria, Zain Zaki (2020 , Dissertation)The heart develops through an extremely intricate process mediated by a network of transcription factors initiated by key chromatin modification events. Scientist have implicated the protein arginine methyltransferase ...