Browsing by Author "Shkoor, Mohanad"
Now showing items 1-15 of 15
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DMAP-Catalyzed Reaction of Diethyl 1,3-Acetonedicarboxylate with 2-Hydroxybenzylideneindenediones: Facile Synthesis of Fluorenone-Fused Coumarins
( Thieme Gruppe , 2021 , Article)The base-catalyzed reaction of diethyl 1,3-acetonedicarboxylate with 2-hydroxybenzylidene indenediones was studied. The reaction provides a facile and expeditious protocol for the synthesis of natural product inspired ... -
Exploring the Dynamic Interplay of Deleterious Variants on the RAF1–RAP1A Binding in Cancer: Conformational Analysis, Binding Free Energy, and Essential Dynamics
( Wiley , 2024 , Article)The RAF1–RAP1A interaction activates the MAPK/ERK pathway which is very crucial in the carcinogenesis process. This protein complex influences tumor formation, proliferation, and metastasis. Understanding aberrant interactions ... -
Highly fluorescent push-pull bis-coumarinyl sulfone: Synthesis, photophysical behavior, and solvatochromic response
( Elsevier , 2025 , Article)In this work, 3,3′-sulfonylbis(7-(diethylamino)-2H-chromen-2-one), an effective fluorescent push-pull system, is synthesized and photophysically characterized. The donor-π–acceptor–π–donor (D–π–A–π–D) architecture of the ... -
Integrated structural proteomics and machine learning-guided mapping of a highly protective precision vaccine against mycoplasma pulmonis
( Elsevier , 2024 , Article)Mycoplasma pulmonis (M. pulmonis) is an emerging respiratory infection commonly linked to prostate cancer, and it is classified under the group of mycoplasmas. Improved management of mycoplasma infections is essential due ... -
Investigating the role of functional mutations in leucine binding to Sestrin2 in aging and age-associated degenerative pathologies using structural and molecular simulation approaches
( Taylor & Francis , 2024 , Article)Leucine is the native known ligand of Sestrin2 (Sesn2) and its interaction with Sesn2 is particularly important, as it influences the activity of mTOR in aging and its associated pathologies. It is important to find out ... -
l-Proline-Catalyzed Three-Component Reaction of 4-Chloro-3-formylcoumarin, Sodium Sulfide, and α-Halo Ketones: A Direct Approach to Thieno[3,2- c ]coumarins
( Georg Thieme Verlag KG , 2023 , Article)A new protocol for the synthesis of thieno[3,2-c]coumarins is disclosed. In this method, a 3-formyl-2-oxo-2H-chromene-4-thiolate anion is generated in situ by treatment of 4-chloro-3-formylcoumarin with sodium sulfide. ... -
Mechanochemical arylative detrifluoromethylation of trifluoromethylarenes
( Royal Society of Chemistry , 2023 , Article)The stoichiometric defluorinative functionalization of ArCF3 is a conceptually appealing research target. It enables the challenging late-stage functionalization of CF3-containing aromatic molecules and contributes to the ... -
Mechanochemical Conversion of Aromatic Amines to Aryl Trifluoromethyl Ethers
( American Chemical Society , 2022 , Article)Increased interest in the trifluoromethoxy group in organic synthesis and medicinal chemistry has induced a demand for new, selective, general, and faster methods applicable to natural products and highly functionalized ... -
Mechanochemical Defluorinative Arylation of Trifluoroacetamides: An Entry to Aromatic Amides
( American Chemical Society , 2022 , Article)The amide bond is prominent in natural and synthetic organic molecules endowed with activity in various fields. Among a wide array of amide synthetic methods, substitution on a pre-existing (O)C-N moiety is an underexplored ... -
Mechanochemical Transformation of CF3 Group: Synthesis of Amides and Schiff Bases
( Wiley , 2021 , Article)We communicate two mild, solvent-free mechanochemical coupling transformations of CF3 group with nitro compounds into amides or Schiff bases employing Ytterbia as a catalyst. This process proceeds via C−F bond activation, ... -
Network Pharmacology Integrated With Quantum-Polarized Ligand Docking and Molecular Simulation Revealed the Anti-Diabetic Potential of Curcumin
( Wiley , 2024 , Article)Diabetes mellitus is a chronic metabolic disorder affecting millions of people worldwide and causes serious complications such as diabetic nephropathy. Curcumin, a natural polyphenol derived from turmeric, has demonstrated ... -
Regioselective domino C–C/C–O arylation of 1,2,3-triiodobenzenes and 1,3-diketones: Synthesis and in silico evaluation of 7-iodobenzo[b]furan as potential ALK inhibitors
( Elsevier , 2025 , Article)We report a simple, direct, and regioselective protocol for the synthesis of 2,3-disubstituted 7-iodobenzo[b]furans via domino double CC/CO arylations of 1,2,3-triiodobenzene and 1,3-dicarbonyl compounds. Remarkably, the ... -
Spectrofluorometric investigations on the solvent effects on the photocyclization reaction of diclofenac
( Elsevier , 2023 , Article)The solvent effects on the photochemical conversion rate of the photosensitizing drug diclofenac (DCF) were investigated using steady-state fluorescence spectroscopy. The spectral information obtained for the photochemical ... -
Synthesis of 5-oxo-5H-chromeno[3,4-c]pyridine-1-carbonitriles and features of their NMR spectra
( Wiley , 2019 , Article)Two different methods leading to 5-oxo-5H-chromeno[3,4-c]pyridine-1-carbonitriles were investigated. Reactions of 3-aminocrotonirile with substituted salicylaldehydes provided 5-oxo-5H-chromeno[3,4-c]pyridine-1-carbonitriles ... -
Unusual product from the acid-catalyzed one-pot, multicomponent reaction of thiocarbohydrazide, aldehydes, and phenacyl bromides
( Taylor & Francis , 2017 , Article)A one-pot, three-component protocol for the synthesis of novel five-membered thiazole ring bonded to two hydrazone motifs is described. The acid-catalyzed reaction of one equivalent of thiocarbohydrazide, two equivalents ...
