Browsing by Author "Rizk, Nasser"
Now showing items 1-14 of 14
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Association between Genetic Variants of GC Gene at 4q13.3 and Vitamin D Concentrations in Adult Females
sharif, Elham; Rizk, Nasser; Thakur, Hajera; Kurdi, Tasnim; Alwakeel, Mariam ( Longdom , 2019 , Article)Background: Vitamin D binding protein, encoded by the GC gene (on 4q13.3), plays an important role in transporting vitamin D. Several Genome-Wide Association Studies (GWASs) have established a significant association ... -
ASSOCIATION BETWEEN INSULIN RESISTANCE AND NITRIC OXIDE IN HUMAN RETINAL MICROVASCULAR ENDOTHELIAL CELLS IN VITRO
Bushra, Sumbul (2015 , Master Thesis)Diabetic retinopathy (DR) a major consequence of diabetes is considered the leading cause of vision loss and blindness worldwide among working adults. Endothelial dysfunction expediting imbalance in vascular homeostasis, ... -
Associations of Vitamin D Receptor Polymorphisms with Coronary Artery Diseases
Sharif, Elham; Rizk, Nasser; Abu Aqel, Sirin; Masoud, Ofelia (2016 , Poster)Background: Previous studies have investigated the association of rs1544410, rs7975232 and rs731236 polymorphisms on vitamin D receptor gene and its impact on diseases such as cancer, diabetes and hypertension in different ... -
Brn-3b and PPARy Nuclear Receptor Expression in Adipose Tissue of Human Subjects
Al-Kowari, Moza Khlaifa A.D. (2014 , Master Thesis)Obesity rates have reached alarming heights globally, having more than doubled since the 1980's. Over 60% of diabetic patients are obese, and the increasing severity of the disease is associated with Type 2 Diabetes ... -
EFFECT OF ENDOPLASMIC RETICULUM STRESS MEDIATED BY HYPERGLYCEMIA ON BARRIER FUNCTION IN RETINAL CELLS
Saif, Atiya Ramadan (2016 , Master Thesis)Background: Diabetic Retinopathy (DR) is an inflammatory disease mainly characterized by the dysfunction of the retinal blood vessels. Several studies reported a possible link between the hyperglycemia and the activation ... -
Effect of hypoxia on metabolic markers and gene expression HIF-1 α in adipocytes
Younes, Noura B. (2015 , Master Thesis)Background: Docosahexaenoic acid (DHA; omega-3 fatty acid) has been reported to have potential anti-obesity properties. Hypoxia is a condition that results from the excessive expansion of white adipose tissue resulting in ... -
The frequency of polycystic ovary syndrome in young reproductive females in Qatar
Sharif, Elham; Rahman, Sumaya; Zia, Yumna; Rizk, Nasser ( Dove Medical Press , 2016 , Article)This was a prospective cross-sectional study in which 126 female students between the ages of 18 and 30 years were evaluated for the frequency of polycystic ovary syndrome (PCOS) through clinical interview, questionnaire, ... -
A lipidomic screen of hyperglycemia-treated HRECs links 12/15-Lipoxygenase to microvascular dysfunction during diabetic retinopathy via NADPH oxidase
Ibrahim, Ahmed S.; Elshafey, Sally; Sellak, Hassan; Hussein, Khaled A.; El-Sherbiny, Mohamed; Abdelsaid, Mohammed; Rizk, Nasser; Beasley, Selina; Tawfik, Amany M.; Smith, Sylvia B.; Al-Shabrawey, Mohamed... more authors ... less authors ( American Society for Biochemistry and Molecular Biology , 2015 , Article)Retinal hyperpermeability and subsequent macular edema is a cardinal feature of early diabetic retinopathy (DR). Here, we investigated the role of bioactive lipid metabolites, in particular 12/15-lipoxygenase (LOX)-derived ... -
Metabolomic biomarkers of pancreatic cancer: a meta-analysis study
Mehta, Khyati Y.; Wu, Hung-Jen; Menon, Smrithi S.; Fallah, Yassi; Zhong, Xiaogang; Rizk, Nasser; Unger, Keith; Mapstone, Mark; Fiandaca, Massimo S.; Federoff, Howard J.; Cheema, Amrita K.... more authors ... less authors ( Impact Journals , 2017 , Article)Pancreatic cancer (PC) is an aggressive disease with high mortality rates, however, there is no blood test for early detection and diagnosis of this disease. Several research groups have reported on metabolomics based ... -
The prevalence of vitamin D deficiency among female college students at Qatar University
Sharif, Elham A.; Rizk, Nasser ( Medical Services Department Saudi Arabian Armed , 2011 , Article)Nowadays vitamin D deficiency is considered as a common problem among many Arab countries including Lebanon, Qatar, Saudi Arabia, UAE and other European countries as documented by many studies (1,2,3,5). Vitamin D is a ... -
The Regulation of BRN3B in Adipocytes by Glucose and Insulin
Abochar, Hiba (2014 , Master Thesis)Obesity is the inappropriate accumulation of excess fat stored in the adipocytes of the adipose tissue. Understanding the molecular mechanisms that regulate the process of the preadipocyte to adipocyte conversion, adipogenesis, ... -
The Relationship Between Leptin and PCOS
Sharif, Elham; Faisal, Amal; Osman, Amal; Rizk, Nasser ( De Gruyter , 2014 , Conference Paper)Background: The ob gene produces a leptin hormone that works as a satiety signal to the hypothalamus. Leptin may have a role in polycystic ovary syndrome (PCOS) via its role on obesity and insulin resistance. Materials ... -
The Role of Systemic Filtrating Organs in Aging and Their Potential in Rejuvenation Strategies
Kassab, Amal; Rizk, Nasser; Prakash, Satya ( MDPI , 2022 , Article Review)Advances in aging studies brought about by heterochronic parabiosis suggest that aging might be a reversable process that is affected by changes in the systemic milieu of organs and cells. Given the broadness of such a ... -
Sulforaphane Downregulates Hepatic Fibroblast Growth Factor 21 (FGF21) of Diet Induced Obese Mice
Rizk, Nasser; Noureldin, Arwa; Galal, Aya; Mohamed, Omnia; ElGamal, Abdelrahman; Elsayegh, Dina... more authors ... less authors ( The Obesity Society , 2020 , Conference Paper)Background: Fibroblast growth factor 21 is a hormone-like protein that plays a critical role as an energy regulator. Sulforaphane (SFN) is expected to have potential therapeutic effects in treating obesity. This study aims ...