Browsing by Author "Rizk, Nasser"
Now showing items 1-20 of 26
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12/15-Lipoxygenase-Derived Lipid Metabolites Induce Retinal Endothelial Cell Barrier Dysfunction: Contribution of NADPH Oxidase
( Public Library of Science , 2013 , Article)The purpose of the current study was to evaluate the effect of 12/15- lipoxygenase (12/15-LOX) metabolites on retinal endothelial cell (REC) barrier function. FITC-dextran flux across the REC monolayers and electrical ... -
Adiponectin Ameliorates Hyperglycemia-Induced Retinal Endothelial Dysfunction, Highlighting Pathways, Regulators, and Networks
( dovepress , 2022 , Article)Background: The pathophysiology of diabetic retinopathy (DR) is multifaced. A low level of circulating adiponectin (APN) in type 2 diabetes is associated with microvasculature complications, and its role in the evolution ... -
Association between Genetic Variants of GC Gene at 4q13.3 and Vitamin D Concentrations in Adult Females
( Longdom , 2019 , Article)Background: Vitamin D binding protein, encoded by the GC gene (on 4q13.3), plays an important role in transporting vitamin D. Several Genome-Wide Association Studies (GWASs) have established a significant association ... -
ASSOCIATION BETWEEN INSULIN RESISTANCE AND NITRIC OXIDE IN HUMAN RETINAL MICROVASCULAR ENDOTHELIAL CELLS IN VITRO
(2015 , Master Thesis)Diabetic retinopathy (DR) a major consequence of diabetes is considered the leading cause of vision loss and blindness worldwide among working adults. Endothelial dysfunction expediting imbalance in vascular homeostasis, ... -
Associations of Vitamin D Receptor Polymorphisms with Coronary Artery Diseases
(2016 , Poster)Background: Previous studies have investigated the association of rs1544410, rs7975232 and rs731236 polymorphisms on vitamin D receptor gene and its impact on diseases such as cancer, diabetes and hypertension in different ... -
Brn-3b and PPARy Nuclear Receptor Expression in Adipose Tissue of Human Subjects
(2014 , Master Thesis)Obesity rates have reached alarming heights globally, having more than doubled since the 1980's. Over 60% of diabetic patients are obese, and the increasing severity of the disease is associated with Type 2 Diabetes ... -
Effect of CYP2C19 genetic variants on bleeding and major adverse cardiovascular events in a cohort of Arab patients undergoing percutaneous coronary intervention and stent implantation
( Lippincott Williams and Wilkins , 2022 , Article)Introduction One-third of patients have clopidogrel resistance that may lead to major adverse cardiac events (MACEs). By contrast, it was found that some clopidogrel-treated patients have hyperresponsive platelets that are ... -
EFFECT OF ENDOPLASMIC RETICULUM STRESS MEDIATED BY HYPERGLYCEMIA ON BARRIER FUNCTION IN RETINAL CELLS
(2016 , Master Thesis)Background: Diabetic Retinopathy (DR) is an inflammatory disease mainly characterized by the dysfunction of the retinal blood vessels. Several studies reported a possible link between the hyperglycemia and the activation ... -
The effect of genetic and nongenetic factors on warfarin dose variability in Qatari population.
( Pharmacogenomics Journal , 2020 , Article)The objective of this study is to estimate the prevalence of VKORC1, CYP2C9, and CYP4F2 genetic variants and their contribution to warfarin dose variability in Qataris. One hundred and fifty warfarin-treated Qatari patients ... -
Effect of hypoxia on metabolic markers and gene expression HIF-1 α in adipocytes
(2015 , Master Thesis)Background: Docosahexaenoic acid (DHA; omega-3 fatty acid) has been reported to have potential anti-obesity properties. Hypoxia is a condition that results from the excessive expansion of white adipose tissue resulting in ... -
Effect of sera from elite athletes on cytokine secretion and insulin signaling in preadipocytes and skeletal muscle cells
( Frontiers Media , 2022 , Article)Introduction: The immunomodulatory effect of physical activity can impact insulin signaling differentially in adipose tissues and skeletal muscle cells, depending on sport intensity. In this study, the effect of serum from ... -
The frequency of polycystic ovary syndrome in young reproductive females in Qatar
( Dove Medical Press , 2016 , Article)This was a prospective cross-sectional study in which 126 female students between the ages of 18 and 30 years were evaluated for the frequency of polycystic ovary syndrome (PCOS) through clinical interview, questionnaire, ... -
Hepatic Gene Expression Profile of Lipid Metabolism of Obese Mice After Treatment with AntiObesity Drug
( Qatar University Press , 2020 , Poster)Obesity is a global disorder with multifactorial causes. The liver plays a vital role in fat metabolism. Disorder of hepatic fat metabolism is associated with obesity and causes fatty liver. High fat diet intake (HFD) to ... -
LABORATORIES PREPAREDNESS IN RESPONSE TO COVID 19 PANDEMIC IN QATAR STRATEGIC PLANNING AND EMERGENCY SUPPLY CHAIN MANAGEMENT
(2022 , Professional Masters Project)Introduction: the purpose of this study is to investigate the preparedness of laboratories in Qatar on provisions of essential supplies in pandemic through assesses Supply Chain Management capabilities and its resilience ... -
A lipidomic screen of hyperglycemia-treated HRECs links 12/15-Lipoxygenase to microvascular dysfunction during diabetic retinopathy via NADPH oxidase
( American Society for Biochemistry and Molecular Biology , 2015 , Article)Retinal hyperpermeability and subsequent macular edema is a cardinal feature of early diabetic retinopathy (DR). Here, we investigated the role of bioactive lipid metabolites, in particular 12/15-lipoxygenase (LOX)-derived ... -
Lipidomics for the Prediction of the Unstable Coronary Plaque
( Hamad bin Khalifa University Press (HBKU Press) , 2016 , Conference Paper)Plaques that build up in the lining of the coronary arteries are made up of lipids, inflammatory cells, smooth muscle cells and connective tissue. Thormbosis of a not necessarily occlusive but unstable plaque most often ... -
Metabolomic biomarkers of pancreatic cancer: a meta-analysis study
( Impact Journals , 2017 , Article)Pancreatic cancer (PC) is an aggressive disease with high mortality rates, however, there is no blood test for early detection and diagnosis of this disease. Several research groups have reported on metabolomics based ... -
Pigment epithelium-derived factor inhibits retinal microvascular dysfunction induced by 12/15-lipoxygenase-derived eicosanoids
( Elsevier , 2015 , Article)We recently demonstrated that 12/15-lipoxygenase (LOX) derived metabolites, hydroxyeicosatetraenoic acids (HETEs), contribute to diabetic retinopathy (DR) via NADPH oxidase (NOX) and disruption of the balance in retinal ... -
The prevalence of vitamin D deficiency among female college students at Qatar University
( Medical Services Department Saudi Arabian Armed , 2011 , Article)Nowadays vitamin D deficiency is considered as a common problem among many Arab countries including Lebanon, Qatar, Saudi Arabia, UAE and other European countries as documented by many studies (1,2,3,5). Vitamin D is a ... -
The Regulation of BRN3B in Adipocytes by Glucose and Insulin
(2014 , Master Thesis)Obesity is the inappropriate accumulation of excess fat stored in the adipocytes of the adipose tissue. Understanding the molecular mechanisms that regulate the process of the preadipocyte to adipocyte conversion, adipogenesis, ...
