Browsing by Author "Habib, Abdella M."

Now showing items 1-11 of 11

    • Biased signaling: A viable strategy to drug ghrelin receptors for the treatment of obesity 

      Karim, Nagi; Habib, Abdella M. ( Elsevier , 2021 , Article)
      Obesity is a global burden and a chronic ailment with damaging overall health effects. Ghrelin, an octanoylated 28 amino acid peptide hormone, is secreted from the oxyntic mucosa of the stomach. Ghrelin acts on regions of ...

    • Distinct transcriptional responses of mouse sensory neurons in models of human chronic pain conditions [version 1; referees: 2 approved] 

      BangaBangash M.A.; Alles, Sascha R. A.; Santana-Varela, Sonia; Millet, Queensta; Sikandar, Shafaq; ... more authors ( F1000 Research Ltd , 2018 , Article)
      Background: Sensory neurons play an essential role in almost all pain conditions, and have recently been classified into distinct subsets on the basis of their transcriptomes. Here we have analysed alterations in dorsal ...

    • Identification of FAM173B as a protein methyltransferase promoting chronic pain 

      Willemen, Hanneke L. D. M.; Kavelaars, Annemieke; Prado, Judith; Maas, Mirjam; Versteeg, Sabine; ... more authors ( Public Library of Science , 2018 , Article)
      Chronic pain is a debilitating problem, and insights in the neurobiology of chronic pain are needed for the development of novel pain therapies. A genome-wide association study implicated the 5p15.2 region in chronic ...

    • The impact of prior obesity surgery on glucose metabolism after body contouring surgery: A pilot study. 

      Badran, Saif; Doi, Suhail A; Hammouda, Atalla; Khoogaly, Hoda; Muneer, Mohammad; ... more authors ( Europe PMC , 2023 , Article)
      Body contouring surgery enhances physical appearance by means of surgical subcutaneous fat removal (SSFR). However, it remains unclear how SSFR may affect glucose metabolism and its broader effects on the endocrine system, ...

    • Metabolic aspects of surgical subcutaneous fat removal: an umbrella review and implications for future research. 

      Badran, Saif; Doi, Suhail A; Hamdi, Moustapha; Hammouda, Atalla; Alharami, Sara; ... more authors ( Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina , 2022 , Article Review)
      Although obesity is a preventable disease, maintaining a normal body weight can be very challenging and difficult, which has led to a significant increase in the demand for surgical subcutaneous fat removal (SSFR) to improve ...

    • Metabolic changes after nonsurgical fat removal: A dose response meta-analysis 

      Saif, Badran; Doi, Suhail A.; Iskeirjeh, Sara; Aljassem, Ghanem; Jafarian, Nasrin; ... more authors ( Elsevier , 2023 , Article Review)
      BackgroundObesity-induced insulin resistance leads to the metabolic syndrome. Both bariatric surgery and surgical fat removal have been shown to improve metabolic health, but the metabolic benefits of nonsurgical fat removal ...

    • Metabolic changes after surgical fat removal: A dose–response meta-analysis 

      Saif, Badran; Habib, Abdella M.; Aljassem, Ghanem; Musa, Omran A.H.; Clark, Justin; ... more authors ( Elsevier , 2023 , Article Review)
      BackgroundBariatric surgery averts obesity-induced insulin resistance and the metabolic syndrome. By contrast, surgical fat removal is considered merely an esthetic endeavor. The aim of this article was to establish whether ...

    • Microdeletion in a FAAH pseudogene identified in a patient with high anandamide concentrations and pain insensitivity 

      Habib, Abdella M.; Okorokov, Andrei L.; Hill, Beta Matthew Nicholas; Bras, Jose T.; Lee, Man-Cheung; ... more authors ( Elsevier , 2019 , Article)
      The study of rare families with inherited pain insensitivity can identify new human-validated analgesic drug targets. Here, a 66-yr-old female presented with nil requirement for postoperative analgesia after a normally ...

    • Molecular basis of FAAH-OUT-associated human pain insensitivity. 

      Mikaeili, Hajar; Habib, Abdella M; Yeung, Charlix Wai-Lok; Santana-Varela, Sonia; Luiz, Ana P; ... more authors ( Oxford University Press , 2023 , Article)
      Chronic pain affects millions of people worldwide and new treatments are needed urgently. One way to identify novel analgesic strategies is to understand the biological dysfunctions that lead to human inherited pain ...

    • Pain-causing stinging nettle toxins target TMEM233 to modulate NaV1.7 function 

      Jami, Sina; Deuis, Jennifer R.; Klasfauseweh, Tabea; Cheng, Xiaoyang; Kurdyukov, Sergey; ... more authors ( Nature Research , 2023 , Article)
      Voltage-gated sodium (NaV) channels are critical regulators of neuronal excitability and are targeted by many toxins that directly interact with the pore-forming α subunit, typically via extracellular loops of the ...

    • Vitamin D and Its Potential Interplay With Pain Signaling Pathways 

      Habib, Abdella M; Nagi, Karim; Thillaiappan, Nagendra Babu; Akhtar, Saghir; vijayakumar, sukumaran ( Frontiers Media , 2020 , Article Review)
      About 50 million of the U.S. adult population suffer from chronic pain. It is a complex disease in its own right for which currently available analgesics have been deemed woefully inadequate since ~20% of the sufferers ...