Browsing by Author "Habib, Abdella M."

Now showing items 1-20 of 20

    • Biased signaling: A viable strategy to drug ghrelin receptors for the treatment of obesity 

      Karim, Nagi; Habib, Abdella M. ( Elsevier , 2021 , Article)
      Obesity is a global burden and a chronic ailment with damaging overall health effects. Ghrelin, an octanoylated 28 amino acid peptide hormone, is secreted from the oxyntic mucosa of the stomach. Ghrelin acts on regions of ...

    • Bioelectrical Impedance Analysis Detects Body Fat Changes After Surgical Subcutaneous Fat Removal 

      Ahmed, Mohamed Badie; Doi, Suhail A.; Habib, Abdella M.; Glass, Graeme E.; Hammouda, Atalla; ... more authors ( Mary Ann Liebert , 2024 , Article)
      Background: The risk and metabolic effects of obesity are determined by the distribution of fat throughout the body. It has been proposed that the distribution of abdominal fat is more closely related to the metabolic risks ...

    • Distinct transcriptional responses of mouse sensory neurons in models of human chronic pain conditions [version 1; referees: 2 approved] 

      BangaBangash M.A.; Alles, Sascha R. A.; Santana-Varela, Sonia; Millet, Queensta; Sikandar, Shafaq; ... more authors ( F1000 Research Ltd , 2018 , Article)
      Background: Sensory neurons play an essential role in almost all pain conditions, and have recently been classified into distinct subsets on the basis of their transcriptomes. Here we have analysed alterations in dorsal ...

    • Hormonal predictors of the insulin sensitive phenotype in humans. 

      Ahmed, Mohamed Badie; Habib, Abdella M; Badran, Saif; Alsherawi, Abeer; Elnefaily, Sherouk Essam; ... more authors ( Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina , 2025 , Article)
      Clinical obesity, a chronic condition marked by excessive fat accumulation, often leads to insulin resistance and a heightened risk of comorbidities. This study aimed to identify hormonal predictors of an insulin-sensitive ...

    • Hormonal predictors of the lean phenotype in humans. 

      Ahmed, Mohamed Badie; Habib, Abdella M; Badran, Saif; Alsherawi, Abeer; Al-Mohannadi, Fatima; ... more authors ( Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina , 2025 , Article)
      Clinical obesity is characterized by excessive fat accumulation and an increased risk of numerous associated comorbidities. Adipose tissue secretes leptin and other adipokines, which play key roles in regulating energy ...

    • Identification of FAM173B as a protein methyltransferase promoting chronic pain 

      Willemen, Hanneke L. D. M.; Kavelaars, Annemieke; Prado, Judith; Maas, Mirjam; Versteeg, Sabine; ... more authors ( Public Library of Science , 2018 , Article)
      Chronic pain is a debilitating problem, and insights in the neurobiology of chronic pain are needed for the development of novel pain therapies. A genome-wide association study implicated the 5p15.2 region in chronic ...

    • The impact of prior obesity surgery on glucose metabolism after body contouring surgery: A pilot study. 

      Badran, Saif; Doi, Suhail A; Hammouda, Atalla; Khoogaly, Hoda; Muneer, Mohammad; ... more authors ( Europe PMC , 2023 , Article)
      Body contouring surgery enhances physical appearance by means of surgical subcutaneous fat removal (SSFR). However, it remains unclear how SSFR may affect glucose metabolism and its broader effects on the endocrine system, ...

    • Liraglutide induces enhanced suppression of food intake in mice lacking the growth hormone secretagogue receptor 

      Cassano, Daniela A.; Aguggia, Julieta; Giovanini, Lucía; Heredia, Florencia; De Francesco, Pablo N.; ... more authors ( Elsevier , 2025 , Article)
      The glucagon-like peptide-1 receptor (GLP-1R) and the growth hormone secretagogue receptor (GHSR) exert opposing effects on food intake. GLP-1R activation produces potent appetite-suppressing effects, whereas GHSR activation ...

    • MDFIC2 is a PIEZO channel modulator that can alleviate mechanical allodynia associated with neuropathic pain 

      Habib, Abdella M.; Li, Shengnan; Zhang, Chenjing; Ji, Meijun; Osorio, Nancy; ... more authors ( National Academy of Sciences , 2025 , Article)
      PIEZO channels are mechanical force sensors involved in various biological processes, including somatosensation. To date, only a few PIEZO-binding partners have been identified, including MyoD-family inhibitor proteins ...

    • Metabolic aspects of surgical subcutaneous fat removal: an umbrella review and implications for future research. 

      Badran, Saif; Doi, Suhail A; Hamdi, Moustapha; Hammouda, Atalla; Alharami, Sara; ... more authors ( Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina , 2022 , Article Review)
      Although obesity is a preventable disease, maintaining a normal body weight can be very challenging and difficult, which has led to a significant increase in the demand for surgical subcutaneous fat removal (SSFR) to improve ...

    • Metabolic changes after nonsurgical fat removal: A dose response meta-analysis 

      Saif, Badran; Doi, Suhail A.; Iskeirjeh, Sara; Aljassem, Ghanem; Jafarian, Nasrin; ... more authors ( Elsevier , 2023 , Article Review)
      BackgroundObesity-induced insulin resistance leads to the metabolic syndrome. Both bariatric surgery and surgical fat removal have been shown to improve metabolic health, but the metabolic benefits of nonsurgical fat removal ...

    • Metabolic changes after surgical fat removal: A dose–response meta-analysis 

      Saif, Badran; Habib, Abdella M.; Aljassem, Ghanem; Musa, Omran A.H.; Clark, Justin; ... more authors ( Elsevier , 2023 , Article Review)
      BackgroundBariatric surgery averts obesity-induced insulin resistance and the metabolic syndrome. By contrast, surgical fat removal is considered merely an esthetic endeavor. The aim of this article was to establish whether ...

    • Microdeletion in a FAAH pseudogene identified in a patient with high anandamide concentrations and pain insensitivity 

      Habib, Abdella M.; Okorokov, Andrei L.; Hill, Beta Matthew Nicholas; Bras, Jose T.; Lee, Man-Cheung; ... more authors ( Elsevier , 2019 , Article)
      The study of rare families with inherited pain insensitivity can identify new human-validated analgesic drug targets. Here, a 66-yr-old female presented with nil requirement for postoperative analgesia after a normally ...

    • Molecular basis of FAAH-OUT-associated human pain insensitivity. 

      Mikaeili, Hajar; Habib, Abdella M; Yeung, Charlix Wai-Lok; Santana-Varela, Sonia; Luiz, Ana P; ... more authors ( Oxford University Press , 2023 , Article)
      Chronic pain affects millions of people worldwide and new treatments are needed urgently. One way to identify novel analgesic strategies is to understand the biological dysfunctions that lead to human inherited pain ...

    • Out of the dark: the emerging roles of lncRNAs in pain 

      Habib, Abdella M.; Cox, James J.; Okorokov, Andrei L. ( Elsevier , 2024 , Article Review)
      The dark genome, the nonprotein-coding part of the genome, is replete with long noncoding RNAs (lncRNAs). These functionally versatile transcripts, with specific temporal and spatial expression patterns, are critical gene ...

    • Pain-causing stinging nettle toxins target TMEM233 to modulate NaV1.7 function 

      Jami, Sina; Deuis, Jennifer R.; Klasfauseweh, Tabea; Cheng, Xiaoyang; Kurdyukov, Sergey; ... more authors ( Nature Research , 2023 , Article)
      Voltage-gated sodium (NaV) channels are critical regulators of neuronal excitability and are targeted by many toxins that directly interact with the pore-forming α subunit, typically via extracellular loops of the ...

    • Pre-prandial plasma liver-expressed antimicrobial peptide 2 (LEAP2) concentration in humans is inversely associated with hunger sensation in a ghrelin independent manner 

      Andreoli, María; Fittipaldi, Antonela S.; Castrogiovanni, Daniel; De Francesco, Pablo N.; Valdivia, Spring; ... more authors ( Springer Science and Business Media Deutschland GmbH , 2023 , Article)
      Purpose The liver-expressed antimicrobial peptide 2 (LEAP2) is a newly recognized peptide hormone that acts via the growth hormone secretagogue receptor (GHSR) blunting the effects of ghrelin and displaying ghrelin-independent ...

    • Selective Colocalization of GHSR and GLP-1R in a Subset of Hypothalamic Neurons and Their Functional Interaction 

      Aguggia, Julieta; Fernandez, Gimena; Cassano, Daniela; Mustafá,, Emilio R.; Rodríguez, Silvia S.; ... more authors ( Oxford University Press , 2024 , Article)
      The GH secretagogue receptor (GHSR) and the glucagon-like peptide-1 receptor (GLP-1R) are G protein-coupled receptors with critical, yet opposite, roles in regulating energy balance. Interestingly, these receptors are ...

    • Spexin is a biomarker of the process that regulates leptin sensitivity 

      Mohamed Badie, Ahmed; Habib, Abdella M.; Badran, Saif; Alsherawi, Abeer; Syed, Asma; ... more authors ( Elsevier , 2025 , Article)
      The rising prevalence of obesity poses a critical threat to global health, prompting an urgent need for a comprehensive understanding of its underlying mechanisms. This study aimed to delve into the relationship between ...

    • Vitamin D and Its Potential Interplay With Pain Signaling Pathways 

      Habib, Abdella M; Nagi, Karim; Thillaiappan, Nagendra Babu; Akhtar, Saghir; vijayakumar, sukumaran ( Frontiers Media , 2020 , Article Review)
      About 50 million of the U.S. adult population suffer from chronic pain. It is a complex disease in its own right for which currently available analgesics have been deemed woefully inadequate since ~20% of the sufferers ...