Browsing by Author "n 94093822"
Now showing items 1-20 of 24
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Acinic cell carcinoma of the breast: A comprehensive review
( Elsevier , 2022 , Article)Acinic cell carcinoma of the breast is a rare special subtype of breast cancer in the category of salivary gland-type tumors. It is morphologically similar to acinic cell carcinomas of salivary glands and pancreas and has ... -
Ang-(1-7)/ MAS1 receptor axis inhibits allergic airway inflammation via blockade of Src-mediated EGFR transactivation in a murine model of asthma.
( PLoS ONE , 2019 , Article)The angiotensin-(1-7) [Ang-(1-7)]/MAS1 receptor signaling axis is a key endogenous anti-inflammatory signaling pathway. However, the mechanisms by which its mediates the anti-inflammatory effects are not completely understood. ... -
Attenuating amygdalin (vitamin B17) toxicity for potential therapeutic uses: insights into controlled release technology-based formulations as a strategy for improving clinical safety
( Taylor and Francis , 2025 , Article)Introduction: Amygdalin, is arguably, one of the most controversial molecules found in nature, with several therapeutic properties, including anticancer, but there are concerns over its toxicity in healthy tissue alike, ... -
The cardiac toxicity of PAMAM dendrimer drug delivery systems can be attenuated with the adjunct use of cardioprotective agents.
(2024 , Article)Polyamidoamine (PAMAM) dendrimer nanoparticles are efficient drug delivery vectors with potential clinical applications in nanomedicine. However, PAMAMs can compromise heart function, and strategies to mitigate cardiotoxicity ... -
Chronic administration of nano-sized PAMAM dendrimers in vivo inhibits EGFR-ERK1/2-ROCK signaling pathway and attenuates diabetes-induced vascular remodeling and dysfunction.
( Elsevier , 2019 , Article)We investigated whether chronic administration of nano-sized polyamidoamine (PAMAM) dendrimers can have beneficial effects on diabetes-induced vascular dysfunction by inhibiting the epidermal growth factor receptor ... -
COVID-19 and Alzheimer's disease: Impact of lockdown and other restrictive measures during the COVID-19 pandemic.
( the Association of Basic Medical Sciences , 2023 , Article Review)Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection initially results in respiratory distress symptoms but can also lead to central nervous system (CNS) and neurological manifestations, significantly ... -
Critical appraisal of predatory journals in pathology.
( BMJ , 2019 , Article)Predatory journals refer to journals that recruit articles through aggressive marketing and spam emails, promising a quick, but not robust, review and fast open-access (OA) publication, thus compromising scholarly publishing ... -
Diabetes-induced peripheral neuropathy: Is prescribing physical exercise the answer?
( Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina , 2024 , Article)Diabetes mellitus, a chronic metabolic disorder characterized by hyperglycemia, has become a global health concern with an increasing prevalence worldwide. The International Diabetes Federation (IDF) estimates that over ... -
Epstein-Barr Virus and Human Papillomaviruses Interactions and Their Roles in the Initiation of Epithelial-Mesenchymal Transition and Cancer Progression.
( Frontiers Media , 2018 , Article Review)Oncoviruses are implicated in around 20% of all human cancers including both solid and non-solid malignancies. Epstein-Barr virus (EBV) and human papillomaviruses (HPVs) are the most common oncoviruses worldwide. Currently, ... -
Epstein-Barr Virus in Gliomas: Cause, Association, or Artifact?
( Frontiers Media , 2018 , Article Review)Gliomas are the most common malignant brain tumors and account for around 60% of all primary central nervous system cancers. Glioblastoma multiforme (GBM) is a grade IV glioma associated with a poor outcome despite recent ... -
HDL attenuates Ang II–AT1R–EGFR signaling and reverses vascular remodeling in spontaneously hypertensive rats
( Frontiers , 2025 , Article)Background: Angiotensin II (Ang II) signaling via angiotensin II type 1 receptor (AT1R) and transactivation of epidermal growth factor receptor (EGFR) enhances vascular smooth muscle cell (VSMC) proliferation and contributes ... -
The Impact of Pamam Dendrimers on Her2-Positive Breast Cancer and the Early Stages of Embryogenesis
(2020 , Master Thesis)Poly (amidoamine) (PAMAM) dendrimers are widely used in drug delivery systems and gene transfection as drug carriers. They also exert several biological effects including modulating gene expression and interfering with ... -
In honour of Professor Ruth Duncan, recipient of the Journal of Drug Targeting's Lifetime Achievement Award for 2017
( Taylor and Francis Ltd , 2017 , Article)A photograph of Professor Ruth Duncan, recipient of the Journal of Drug Targeting’s Lifetime Achievement Award for 2017 (courtesy of R. Duncan).It is the time of year to honour the recipient of the Journal of Drug Targeting’s ... -
Is there truly an increase in risk of cardiovascular and hematological adverse events with vascular endothelial growth factor receptor tyrosine kinase inhibitors?
( Taylor & Francis , 2019 , Article)Recent studies have shown an increase risk of cardiovascular and hematological adverse events associated with vascular endothelial growth factor tyrosine kinase inhibitors (VEGF-TKIs). The authors hypothesize that the ... -
Mitigating Cardiotoxicity of Dendrimers: Angiotensin-(1-7) via Its Mas Receptor Ameliorates PAMAM-Induced Cardiac Dysfunction in the Isolated Mammalian Heart
( Multidisciplinary Digital Publishing Institute (MDPI) , 2022 , Article)Aim: The influence of the physiochemical properties of dendrimer nanoparticles on cardiac contractility and hemodynamics are not known. Herein, we investigated (a) the effect of polyamidoamine (PAMAM) dendrimer generation ... -
Naked Poly(amidoamine) Dendrimer Nanoparticles Exhibit Intrinsic Embryotoxicity During the Early Stages of Normal Development.
( American Science Publishers ASP , 2020 , Article)To investigate the impact of poly(amidoamine) dendrimers (PAMAMs) in the embryo, we explored the outcome of different generations (G₄ and G) on the early stages of embryogenesis using the chicken embryo as a model. We also ... -
PAMAM Dendrimers as Anti-HER2 Positive Breast Cancer Treatment
( Qatar University Press , 2020 , Poster)Background: Poly (amidoamine) dendrimers (PAMAMs) are widely used in drug delivery systems and gene transfection as drug carriers. They also exert several biological effects like modulating gene expression, particularly ... -
Recent advances in stem cell-based therapies for type 1 diabetes: A glimpse into the future.
( The Association of Basic Medical Sciences , 2025 , Article Review)Type 1 diabetes mellitus (T1DM) is a serious, chronic metabolic and autoimmune disease that affects millions globally. While insulin administration remains the most effective treatment, it is not a cure. Long-term therapies, ... -
The Role of Epstein-Barr Virus in Cervical Cancer: A Brief Update.
( Frontiers Media , 2018 , Article Review)Epstein-Barr virus (EBV) belongs to the group of gamma-herpes viruses and was the first recognized human oncovirus. EBV is responsible for infectious mononucleosis and multiple lymphoid and epithelial malignancies including ... -
Substantial cell apoptosis provoked by naked PAMAM dendrimers in HER2-positive human breast cancer via JNK and ERK1/ERK2 signalling pathways
( Elsevier , 2021 , Article)HER2-positive breast cancer is one of its most challenging subtypes, forming around 15–25% of the total cases. It is characterized by aggressive behavior and treatment resistance. On the other hand, poly (amidoamine) (PAMAM) ...
