Browsing by Author "n 93088512"
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Blood pressure and bladder cancer risk in men by use of survival analysis and in interaction with NAT2 genotype, and by Mendelian randomization analysis
Teleka, Stanley; Hindy, George; Drake, Isabel; Poveda, Alaitz; Melander, Olle; Liedberg, Fredrik; Orho-Melander, Marju; Stocks, Tanja... more authors ... less authors ( Public Library of Science , 2020 , Article)The association between blood pressure (BP) and bladder cancer (BC) risk remains unclear with confounding by smoking being of particular concern. We investigated the association between BP and BC risk among men using ... -
Genome-wide polygenic score, clinical risk factors, and long-term trajectories of coronary artery disease
Hindy, George; Aragam, Krishna G.; Ng, Kenney; Chaffin, Mark; Lotta, Luca A.; Baras, Aris; Drake, Isabel; Orho-Melander, Marju; Melander, Olle; Kathiresan, Sekar; Khera, Amit V.... more authors ... less authors ( American Heart Association , 2020 , Article)OBJECTIVE: To determine the relationship of a genome-wide polygenic score for coronary artery disease (GPSCAD) with lifetime trajectories of CAD risk, directly compare its predictive capacity to traditional risk factors, ... -
Methodological considerations for identifying multiple plasma proteins associated with all-cause mortality in a population-based prospective cohort
Drake, Isabel; Hindy, George; Almgren, Peter; Engström, Gunnar; Nilsson, Jan; Melander, Olle; Orho-Melander, Marju... more authors ... less authors ( Nature Research , 2021 , Article)Novel methods to characterize the plasma proteome has made it possible to examine a wide range of proteins in large longitudinal cohort studies, but the complexity of the human proteome makes it difficult to identify robust ...