Browsing by Author "n 2015017406"

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Aberrant DNA methylation of PTPRG as one possible mechanism of its under-expression in CML patients in the State of Qatar

Ismail, Mohamed A; Samara, Muthanna; Al Sayab, Ali; Alsharshani, Mohamed; Yassin, Mohamed A; Varadharaj, Govindarajulu; Vezzalini, Marzia; Tomasello, Luisa; Monne, Maria; Morsi, Hisham; Qoronfleh, M Walid; Zayed, Hatem; Cook, Richard; Sorio, Claudio; Modjtahedi, Helmout; Al-Dewik, Nader I... more authors ... less authors ( Wiley Open Access , 2020 , Article)
Several studies showed that aberrant DNA methylation is involved in leukemia and cancer pathogenesis. Protein tyrosine phosphatase receptor gamma (PTPRG) expression is a natural inhibitory mechanism that is downregulated ...
Description of PTPRG genetic variants identified in a cohort of Chronic Myeloid Leukemia patients and their ability to influence response to Tyrosine kinase Inhibitors

Mohamed A., Ismail; Nasrallah, Gheyath K.; Monne, Maria; AlSayab, Ali; Yassin, Mohamed A.; Varadharaj, Govindarajulu; Younes, Salma; Sorio, Claudio; Cook, Richard; Modjtahedi, Helmout; Al-Dewik, Nader I.... more authors ... less authors ( Elsevier , 2022 , Article)
Tyrosine kinase inhibitors (TKIs) have remarkably transformed Ph+ chronic myeloid leukemia (CML) management; however, TKI resistance remains a major clinical challenge. Mutations in BCR-ABL1 are well studied but fail to ...