تصفح حسب المؤلف "Kobeissy, Firas"
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2-Nucleobase-substituted 4,6-Diaminotriazine Analogs: Synthesis and Anti-cancer Activity in 5-Fluorouracil-Sensitive and Resistant Colorectal Cancer Cells.
Hamze, Khalil; Abdallah, Rola H; Younis, Nour K; Fardoun, Manal; Darwiche, Nadine; Kobeissy, Firas; Iratni, Rabah; Bouhadir, Kamal; Eid, Ali H... more authors ... less authors ( Bentham Science Publishers , 2022 , Article)Cancer continues to be the second leading cause of death worldwide with colorectal cancer (CRC) being the third most common type. Despite significant advances in cancer therapies, current treatment of CRC remains suboptimal. ... -
Acute exposure to cigarette smoking followed by myocardial infarction aggravates renal damage in an in vivo mouse model
Kobeissy, Firas; Shaito, Abdullah; Kaplan, Abdullah; Baki, Lama; Hayek, Hassan; Dagher-Hamalian, Carole; Nehme, Ali; Ghali, Rana; Abidi, Emna; Husari, Ahmad; Zeidan, Asad; Zouein, Fouad A.; Zibara, Kazem... more authors ... less authors ( Hindawi Limited , 2017 , Article)Cigarette smoking (S) is a risk factor for progressive chronic kidney disease, renal dysfunction, and renal failure. In this study, the effect of smoking on kidney function was investigated in a mouse model of myocardial ... -
Advances in Cardiovascular Biomarker Discovery.
Ghantous, Crystal M; Kamareddine, Layla; Farhat, Rima; Zouein, Fouad A; Mondello, Stefania; Kobeissy, Firas; Zeidan, Asad... more authors ... less authors ( MDPI , 2020 , Article Review)Cardiovascular diseases are the leading causes of mortality worldwide. Among them, hypertension and its pathological complications pose a major risk for the development of other cardiovascular diseases, including heart ... -
Assessing the psychological impact of Beirut Port blast: A cross-sectional study
Al Hariri, Moustafa; Zgheib, Hady; Abi Chebl, Karen; Azar, Maria; Hitti, Eveline; Bizri, Maya; Rizk, Jennifer; Kobeissy, Firas; Mufarrij, Afif... more authors ... less authors ( Lippincott, Williams & Wilkins , 2022 , Article)Beirut Port blast's magnitude is considered the third after Hiroshima and Nagasaki atomic bombings. This blast occurred in the densely populated section of Beirut, leaving more than six thousand injured patients. The ... -
The Brain And Exercise: In Sickness And In Health
Reslan, Mohammad Amine; Tabet, Maha; Yehya, Yara; Shaito, Abdullah; Kobeissy, Firas ( Frontiers Media , 2022 , Article)The brain, like any other organ in the body, is made up of various types of cells. Nerve cells called neurons are the major cells in the brain. Their main function is to transfer messages and orders to and from the organs ... -
Cannabinoids and Myocardial Ischemia: Novel insights, Updated Mechanisms, and Implications for Myocardial Infarction
El Dahan, Karim Seif; Machtoub, Dima; Massoud, Gaelle; Nasser, Suzanne A.; Hamam, Bassam; Kobeissy, Firas; Zouein, Fouad A.; Eid, Ali H.... more authors ... less authors ( Bentham Science Publishers , 2022 , Article)Cannabis is the most widely trafficked and abused illicit drug due to its calming psychoactive properties. It has been increasingly recognized as having potential health benefits and relatively less adverse health effects ... -
Crosstalk between Microglia and Neurons in Neurotrauma: An Overview of the Underlying Mechanisms.
Haidar, Muhammad Ali; Ibeh, Stanley; Shakkour, Zaynab; Reslan, Mohammad Amine; Nwaiwu, Judith; Moqidem, Yomna Adel; Sader, Georgio; Nickles, Rachel G; Babale, Ismail; Jaffa, Aneese A; Salama, Mohamed; Shaito, Abdullah; Kobeissy, Firas... more authors ... less authors ( Bentham Science Publishers , 2022 , Article Review)Microglia are the resident immune cells of the brain and play a crucial role in housekeeping and maintaining homeostasis of the brain microenvironment. Upon injury or disease, microglial cells become activated, at least ... -
Dysregulation of angiotensin converting enzyme 2 expression and function in comorbid disease conditions possibly contributes to coronavirus infectious disease 2019 complication severity
Hammoud, Safaa H.; Wehbe, Zena; Abdelhady, Samar; Kobeissy, Firas; Eid, Ali H.; El-Yazbi, Ahmed F.... more authors ... less authors ( American Society for Pharmacology and Experimental Therapy , 2021 , Article Review)ACE2 has emerged as a double agent in the COVID-19 ordeal, as it is both physiologically protective and virally conducive. The identification of ACE2 in as many as 72 tissues suggests that extrapulmonary invasion and damage ... -
Early metabolic impairment as a contributor to neurodegenerative disease: Mechanisms and potential pharmacological intervention
Fakih, Walaa; Zeitoun, Ralph; AlZaim, Ibrahim; Eid, Ali H.; Kobeissy, Firas; Abd-Elrahman, Khaled S.; El-Yazbi, Ahmed F.... more authors ... less authors ( Wiley , 2022 , Article Review)The metabolic syndrome comprises a family of clinical and laboratory findings, including insulin resistance, hyperglycemia, hypertriglyceridemia, low high-density lipoprotein cholesterol levels, and hypertension, in addition ... -
Epac as a tractable therapeutic target
Hasan, Slika; Mansour, Hadi; Nasser, Suzanne A.; Shaito, Abdullah; Kobeissy, Firas; Orekhov, Alexander N.; Pintus, Gianfranco; Eid, Ali H.... more authors ... less authors ( Elsevier , 2023 , Article)In 1957, cyclic adenosine monophosphate (cAMP) was identified as the first secondary messenger, and the first signaling cascade discovered was the cAMP-protein kinase A (PKA) pathway. Since then, cAMP has received increasing ... -
Estrogen receptor and the gender bias in Raynaud's phenomenon.
Fardoun, Manal; Kobeissy, Firas; Eid, Ali ( Bentham Science Publishers , 2023 , Other)Cold-induced vasoconstriction is a normal physiological reaction aiming at redirecting blood into internal more vital body organs [1]. It is mediated by sympathetic release of norepinephrine as well as by local effectors ... -
G protein estrogen receptor as a potential therapeutic target in Raynaud’s phenomenon
Fardoun, Manal; Mondello, Stefania; Kobeissy, Firas; Eid, Ali H. ( Frontiers Media , 2022 , Article)Exaggerated cold-induced vasoconstriction can precipitate a pathogenesis called Raynaud’s phenomenon (RP). Interestingly, RP is significantly more prevalent in females than age-matched men, highlighting the potential ... -
High fat diet exacerbates long-term metabolic, neuropathological, and behavioral derangements in an experimental mouse model of traumatic brain injury
Stanley, Ibeh; Bakkar, Nour-Mounira Z.; Ahmad, Fatima; Nwaiwu, Judith; Barsa, Chloe; Mekhjian, Sarine; Reslan, Mohammad Amine; Eid, Ali H.; Harati, Hayat; Nabha, Sanaa; Mechref, Yehia; El-Yazbi, Ahmed F.; Kobeissy, Firas... more authors ... less authors ( Elsevier , 2023 , Article)AimsTraumatic brain injury (TBI) constitutes a serious public health concern. Although TBI targets the brain, it can exert several systemic effects which can worsen the complications observed in TBI subjects. Currently, ... -
Inflammasomes as biomarkers and therapeutic targets in traumatic brain injury and related-neurodegenerative diseases: A comprehensive overview
Dania, Kattan; Barsa, Chloe; Mekhijian, Sarin; Shakkour, Zaynab; Jammoul, Maya; Doumit, Mark; Zabala, Maria Camila Pareja; Darwiche, Nadine; Eid, Ali H.; Mechref, Yehia; Wang, Kevin K.; de Rivero Vaccari, Juan Pablo; Munoz Pareja, Jennifer C.; Kobeissy, Firas... more authors ... less authors ( Elsevier , 2023 , Article)Given the ambiguity surrounding traumatic brain injury (TBI) pathophysiology and the lack of any Food and Drug Administration (FDA)-approved neurotherapeutic drugs, there is an increasing need to better understand the ... -
Inflammation and hypertension: Underlying mechanisms and emerging understandings
Aboukhater, Diana; Morad, Bassel; Nasrallah, Nadim; Nasser, Suzanne A.; Sahebkar, Amirhossein; Kobeissy, Firas; Boudaka, Ammar; Eid, Ali H.... more authors ... less authors ( wiley online library , 2023 , Article Review)Hypertension remains a major contributor to cardiovascular disease (CVD), a leading cause of global death. One of the major insults that drive increased blood pressure is inflammation. While it is the body's defensive ... -
Inflammatory basis of atherosclerosis: Modulation by sex hormones
Nasser, Suzanne A.; Afify, Elham A.; Kobeissy, Firas; Hamam, Bassam; Eid, Ali H.; El-Mas, Mahmoud M.... more authors ... less authors ( Bentham Science Publishers , 2021 , Other)Atherosclerosis-related cardiovascular diseases (CVDs) are the leading cause of death globally. Several lines of evidence are supportive of the contributory role of vascular inflammation in atherosclerosis. Di-verse immune ... -
Mitoquinone supplementation alleviates oxidative stress and pathologic outcomes following repetitive mild traumatic brain injury at a chronic time point
Maha, Tabet; El-Kurdi, Marya; Haidar, Muhammad Ali; Nasrallah, Leila; Reslan, Mohammad Amine; Shear, Deborah; Pandya, Jignesh D.; El-Yazbi, Ahmed F.; Sabra, Mirna; Mondello, Stefania; Mechref, Yehia; Shaito, Abdullah; Wang, Kevin K.; El-Khoury, Riyad; Kobeissy, Firas... more authors ... less authors ( Elsevier , 2022 , Article)Traumatic brain injury (TBI) is a major cause of disability and death. Mild TBI (mTBI) constitutes ~75% of all TBI cases. Repeated exposure to mTBI (rmTBI), leads to the exacerbation of the symptoms compared to single mTBI. ... -
Nano-Engineering in Traumatic Brain Injury
Al-Thani, Najlaa; Haider, Mohammad Z.; Al-Mansoob, Maryam; Patel, Stuti; Ahmad, Salma M.S.; Kobeissy, Firas; Shaito, Abdullah... more authors ... less authors ( Wiley , 2023 , Book chapter)Traumatic brain injury (TBI) is a leading cause of mortality and chronic disability worldwide TBI involves an initial primary phase triggered by an impactful force to the brain and a subsequent secondary pathological phase. ... -
Nanoparticles: Attractive tools to treat colorectal cancer
Nour K., Younis; Roumieh, Rami; Bassil, Emmanuel P.; Ghoubaira, Joseph A.; Kobeissy, Firas; Eid, Ali H.... more authors ... less authors ( Elsevier , 2022 , Article)Colorectal Cancer (CRC) is one of the leading causes of cancer-related deaths worldwide. Despite the notable advances achieved over the last few decades, CRC remains a hard-to-treat deadly disease in many patients. This ... -
Neurotrauma investigation through spatial omics guided by mass spectrometry imaging: Target identification and clinical applications
Mallah, Khalil; Zibara, Kazem; Kerbaj, Coline; Eid, Ali; Khoshman, Nour; Ousseily, Zahraa; Kobeissy, Abir; Cardon, Tristan; Cizkova, Dasa; Kobeissy, Firas; Fournier, Isabelle; Salzet, Michel... more authors ... less authors ( Wiley , 2023 , Article Review)Traumatic brain injury (TBI) represents one of the major public health concerns worldwide due to the increase in TBI incidence as a result of injuries from daily life accidents such as sports and motor vehicle transportation ...