Browsing by Subject "G protein-coupled receptor"

Now showing items 1-2 of 2

Cyclic AMP-Rap1A signaling activates RhoA to induce α2c-adrenoceptor translocation to the cell surface of microvascular smooth muscle cells

Jeyaraj, Selvi C.; Unger, Nicholas T.; Eid, Ali H.; Mitra, Srabani; Paul El-Dahdah, N.; Quilliam, Lawrence A.; Flavahan, Nicholas A.; Chotani, Maqsood A.... more authors ... less authors ( American Physiological Society , 2012 , Article)
Intracellular signaling by the second messenger cyclic AMP (cAMP) activates the Ras-related small GTPase Rap1 through the guanine exchange factor Epac. This activation leads to effector protein interactions, activation, ...
In-frame fusion of SUMO1 enhances βarrestin2's association with activated GPCRs as well as with nuclear pore complexes

Karim, Nagi; Kaur, Suneet; Bai, Yushi; Shenoy, Sudha K. ( Elsevier , 2020 , Article)
Small ubiquitin like modifier (SUMO) conjugation or SUMOylation of βarrestin2 promotes its association with the clathrin adaptor protein AP2 and facilitates rapid β2 adrenergic receptor (β2AR) internalization. However, ...