Browsing by Author "Zupin, Luisa"
Now showing items 21-32 of 32
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Persistent viral infectivity after 27 days from COVID-19 symptoms onset
Zupin, Luisa; Fontana, Francesco; Clemente, Libera; Boschian-Bailo, Pierino; Ruscio, Maurizio; Crovella, Sergio... more authors ... less authors ( BMJ Publishing Group , 2021 , Article)The persistence of SARS-CoV- 2 in pharyngeal swabs belonging to patients affected by COVID-19 is not a rare occurrence. Indeed, the viral load determined through real-time reverse-transcriptase PCR (rRT-PCR) test peaks at ... -
Pleiotropic role of notch signaling in human skin diseases
Gratton, Rossella; Tricarico, Paola Maura; Moltrasio, Chiara; de Oliveira, Ana Sofia Lima Estevão; Brandão, Lucas; Marzano, Angelo Valerio; Zupin, Luisa; Crovella, Sergio... more authors ... less authors ( MDPI , 2020 , Article Review)Notch signaling orchestrates the regulation of cell proliferation, differentiation, migration and apoptosis of epidermal cells by strictly interacting with other cellular pathways. Any disruption of Notch signaling, either ... -
Proteomic study identifies glycolytic and inflammation pathways involved in recurrent otitis media
Ura, Blendi; Celsi, Fulvio; Zupin, Luisa; Arrigoni, Giorgio; Battisti, Ilaria; Gaita, Bartolomea; Grasso, Domenico Leonardo; Orzan, Eva; Sagredini, Raffaella; Barbi, Egidio; Crovella, Sergio... more authors ... less authors ( MDPI , 2020 , Article)Recurrent acute otitis media (RAOM) in children is clinically defined as the occurrence of at least three episodes of acute otitis media over a course of 6 months. A further common pathological condition of interest in the ... -
SARS-CoV-2 does not replicate in HaCaT spontaneously immortalized human keratinocytes: implications for the pathogenesis of COVID-19-associated skin manifestations
Zupin, Luisa; Moltrasio, Chiara; Genovese, Giovanni; Milani, Margherita; Fontana, Francesco; Ruscio, Maurizio; Valerio Marzano, Angelo; Crovella, Sergio... more authors ... less authors ( John Libbey Eurotext , 2022 , Article)Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)-related cutaneous manifestations have been reported [1], however, the direct or indirect role of SARS-CoV-2 infection in their pathophysiology is still debated ... -
SARS-CoV-2 modulates virus receptor expression in placenta and can induce trophoblast fusion, inflammation and endothelial permeability
Agostinis, Chiara; Toffoli, Miriam; Spazzapan, Mariagiulia; Balduit, Andrea; Zito, Gabriella; Mangogna, Alessandro; Zupin, Luisa; Salviato, Tiziana; Maiocchi, Serena; Romano, Federico; Crovella, Sergio; Fontana, Francesco; Braga, Luca; Confalonieri, Marco; Ricci, Giuseppe; Kishore, Uday; Bulla, Roberta... more authors ... less authors ( Frontiers Media , 2022 , Article)SARS-CoV-2 is a devastating virus that induces a range of immunopathological mechanisms including cytokine storm, apoptosis, inflammation and complement and coagulation pathway hyperactivation. However, how the infection ... -
SARS-CoV-2 RNA Recovery from Air Sampled on Quartz Fiber Filters: A Matter of Sample Preservation?
Licen, Sabina; Zupin, Luisa; Martello, Lorenzo; Torboli, Valentina; Semeraro, Sabrina; Gardossi, Anna Lilian; Greco, Enrico; Fontana, Francesco; Crovella, Sergio; Ruscio, Maurizio; Palmisani, Jolanda; Di Gilio, Alessia; Piscitelli, Prisco; Pallavicini, Alberto; Barbieri, Pierluigi... more authors ... less authors ( MDPI , 2022 , Report)The airborne route of transmission of SARS-CoV-2 was confirmed by the World Health Organization in April 2021. There is an urge to establish standardized protocols for assessing the concentration of SARS-CoV-2 RNA in air ... -
SARS-CoV-2 Short-Time Infection Produces Relevant Cytopathic Effects in Vero E6 Cell Line.
Zupin, Luisa; Fontana, Francesco; Gratton, Rossella; Milani, Margherita; Clemente, Libera; Pascolo, Lorella; Ruscio, Maurizio; Crovella, Sergio... more authors ... less authors ( MDPI , 2021 , Article)Severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) is mainly transmitted through respiratory droplets from positive subjects to susceptible hosts or by direct contact with an infected individual. Our study ... -
Strategies and Perspectives for UV Resonance Raman Applicability in Clinical Analyses of Human Sperm RNA.
Pachetti, Maria; D'Amico, Francesco; Zupin, Luisa; Luppi, Stefania; Martinelli, Monica; Crovella, Sergio; Ricci, Giuseppe; Pascolo, Lorella... more authors ... less authors ( MDPI , 2021 , Article)Developing a deeper knowledge about the impact of DNA and RNA epigenetic mutations on sperm production and fertilization performance is essential for selecting best quality samples in Assisted Reproductive Technologies ... -
Think like a Virus: Toward Improving Nanovaccine Development against SARS-CoV-2
Mohamed, Nura A.; Abou-Saleh, Haissam; Mohamed, Hana A.; Al-Ghouti, Mohammad A.; Crovella, Sergio; Zupin, Luisa... more authors ... less authors ( MDPI , 2022 , Article Review)There is no doubt that infectious diseases present global impact on the economy, society, health, mental state, and even political aspects, causing a long-lasting dent, and the situation will surely worsen if and when the ... -
Transient Receptor Potential Ankyrin 1 (TRPA1) Methylation and Chronic Pain: A Systematic Review
Celsi, Fulvio; Peri, Francesca; Cavasin, Julia; Zupin, Luisa; Cozzi, Giorgio; Barbi, Egidio; Crovella, Sergio... more authors ... less authors ( MDPI , 2023 , Other)Background and Objective: Chronic pain represents a major global health issue in terms of psycho-physiological, therapeutic, and economic burden, not limited to adults but also to the pediatric age. Despite its great impact, ... -
Unraveling the Role of Sex Hormones on Keratinocyte Functions in Human Inflammatory Skin Diseases
Gratton, Rossella; Del Vecchio, Cecilia; Zupin, Luisa; Crovella, Sergio ( MDPI , 2022 , Article Review)The skin exerts several fundamental functions that are the first physical, chemical and immune barriers to the human body. Keratinocytes, the main cell type of the epidermis, provide mechanical defense, support skin integrity ... -
Upside-Down Preference in the Forskolin-Induced In Vitro Differentiation of 50B11 Sensory Neurons: A Morphological Investigation by Label-Free Non-Linear Microscopy.
Zupin, Luisa; Psilodimitrakopoulos, Sotiris; Celsi, Fulvio; Papadimitriou, Lina; Ranella, Anthi; Crovella, Sergio; Ricci, Giuseppe; Stratakis, Emmanuel; Pascolo, Lorella... more authors ... less authors ( MDPI , 2023 , Other)In this study, we revealed a peculiar morphological feature of 50B11 nociceptive sensory neurons in in vitro culture related to the forskolin-induced differentiation of these cells growing upside-down on cover glass supports. ...