Browsing by Author "Elrayess, Mohamed A."
Now showing items 21-40 of 62
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From an Apple to a Pear: Moving Fat around for Reversing Insulin Resistance.
Alser, Maha; Elrayess, Mohamed A ( MDPI , 2022 , Article Review)Type 2 diabetes (T2D) is a chronic condition where the body is resistant to insulin, leading to an elevated blood glucose state. Obesity is a main factor leading to T2D. Many clinical studies, however, have described a ... -
GATA-3 as a potential therapeutic target for insulin resistance and type 2 diabetes mellitus.
Al-Jaber, Hend; Al-Mansoori, Layla; Elrayess, Mohamed A ( PubMed Central , 2020 , Article Review)Impaired adipogenesis plays an important role in the development of obesity-associated insulin resistance and type 2 diabetes as it leads to ectopic fat deposition. The anti-adipogenic transcription factor GATA-3 was ... -
Genome-Wide Association Study Reveals a Novel Association Between MYBPC3 Gene Polymorphism, Endurance Athlete Status, Aerobic Capacity and Steroid Metabolism.
Al-Khelaifi, Fatima; Yousri, Noha A; Diboun, Ilhame; Semenova, Ekaterina A; Kostryukova, Elena S; Kulemin, Nikolay A; Borisov, Oleg V; Andryushchenko, Liliya B; Larin, Andrey K; Generozov, Edward V; Miyamoto-Mikami, Eri; Murakami, Haruka; Zempo, Hirofumi; Miyachi, Motohiko; Takaragawa, Mizuki; Kumagai, Hiroshi; Naito, Hisashi; Fuku, Noriyuki; Abraham, David; Hingorani, Aroon; Donati, Francesco; Botrè, Francesco; Georgakopoulos, Costas; Suhre, Karsten; Ahmetov, Ildus I; Albagha, Omar; Elrayess, Mohamed A... more authors ... less authors ( Frontiers Media , 2020 , Article)The genetic predisposition to elite athletic performance has been a controversial subject due to the underpowered studies and the small effect size of identified genetic variants. The aims of this study were to investigate ... -
High Endurance Elite Athletes Show Age-dependent Lower Levels of Circulating Complements Compared to Low/Moderate Endurance Elite Athletes
Al-Muraikhy, S.; Al-Muraikhy, Shamma; Ramanjaneya, Manjunath; Dömling, Alexander S.; Bettahi, Ilham; Donati, Francesco; Botre, Francesco; Abou-Samra, Abdul Badi; Sellami, Maha; Elrayess, Mohamed A.... more authors ... less authors ( Frontiers Media , 2021 , Article)Introduction: Aerobic exercise activates the complement system in the peripheral blood. However, the effect of age and high intensity endurance training on the levels of circulating complements and sassociated inflammatory ... -
Identification of Prognostic Metabolomic Biomarkers at the Interface of Mortality and Morbidity in Pre-Existing TB Cases Infected With SARS-CoV-2
Diboun, I.; Diboun, Ilhame; Cyprian, Farhan S.; Anwardeen, Najeha Rizwana; Yassine, Hadi M.; Elrayess, Mohamed A.; Rahmoon, Samreen Mumtaz; Sayed, Sarah Khaled; Schuchardt, Sven; Khatib, Malkan; Bansal, Devendra; Farag, Elmoubashar Abu Baker Abd; Emara, Mohamed M.; Abdallah, Abdallah M.... more authors ... less authors ( Frontiers Media S.A. , 2022 , Article)Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection currently remains one of the biggest global challenges that can lead to acute respiratory distress syndrome (CARDS) in severe cases. In line with this, ... -
The Impact of Acute and Chronic Exercise on Immunoglobulins and Cytokines in Elderly: Insights From a Critical Review of the Literature.
Sellami, Maha; Bragazzi, Nicola Luigi; Aboghaba, Baha; Elrayess, Mohamed A ( Frontiers Media , 2021 , Article Review)The level of immunoglobulins and cytokines changes with an ageing immune system. This review summarizes findings from studies that have examined the impact of acute and chronic exercise on immunoglobulins and cytokines in ... -
Impact of Moderate Physical Activity on Inflammatory Markers and Telomere Length in Sedentary and Moderately Active Individuals with Varied Insulin Sensitivity
Almuraikhy, Shamma; Sellami, Maha; Al-Amri, Hadaia Saleh; Domling, Alexander; Althani, Asmaa A.; Elrayess, Mohamed A.... more authors ... less authors ( Dove Medical Press , 2023 , Article)Introduction: Physical activity-associated immune response plays a crucial role in the aging process. This study aimed to determine the impact of short-term moderate physical activity on cytokine levels, oxidative stress ... -
Impact of phospholipids, surfactants and cholesterol selection on the performance of transfersomes vesicles using medical nebulizers for pulmonary drug delivery
Iftikhar, Khan; Needham, Rachel; Yousaf, Sakib; Houacine, Chahinez; Islam, Yamir; Bnyan, Ruba; Sadozai, Sajid Khan; Elrayess, Mohamed A.; Elhissi, Abdelbary... more authors ... less authors ( Elsevier , 2021 , Article)The aim of this study is to formulate and optimize novel transfersome formulations for pulmonary drug delivery. Transfersome formulations (F1 – F18) were prepared by a thin-film method using three phospholipids (Soya ... -
In Vitro and In Vivo Validation of GATA-3 Suppression for Induction of Adipogenesis and Improving Insulin Sensitivity
Al-Jaber, Hend; Mohamed, Nura A.; Govindharajan, Vijay K.; Taha, Samir; John, Jomon; Halim, Sharique; Alser, Maha; Al-Muraikhy, Shamma; Anwardeen, Najeha Rizwana; Agouni, Abdelali; Elhissi, Abdelbary; Al-Naemi, Hamda A.; Al-Mansoori, Layla; Elrayess, Mohamed A.... more authors ... less authors ( MDPI , 2022 , Article)Impaired adipogenesis is associated with the development of insulin resistance and an increased risk of type 2 diabetes (T2D). GATA Binding Protein 3 (GATA3) is implicated in impaired adipogenesis and the onset of insulin ... -
Letrozole-loaded nonionic surfactant vesicles prepared via a slurry-based proniosome technology: Formulation development and characterization
Nada, Khudair; Agouni, Abdelali; Elrayess, Mohamed A.; Najlah, Mohammad; Younes, Husam M.; Elhissi, Abdelbary... more authors ... less authors ( Elsevier , 2020 , Article)Slurry-based Letrozole (LTZ)-loaded proniosomes were designed using sucrose or sorbitol as carriers and various ratios of cholesterol (CH) and Tween 80 (T80) as lipid composition. Proniosomes were hydrated and probe-sonicated ... -
Level of Maternal Respiratory Syncytial Virus (RSV) F Antibodies in Hospitalized Children and Correlates of Protection.
Taleb, Sara A; Al-Ansari, Khalid; Nasrallah, Gheyath K; Elrayess, Mohamed A; Al-Thani, Asmaa A; Derrien-Colemyn, Alexandrine; Ruckwardt, Tracy J; Graham, Barney S; Yassine, Hadi M... more authors ... less authors (2021)RSV is a major cause of lower respiratory infections among children, where no vaccine is available. The stabilized form of the fusion (F) protein, pre-F, is a leading vaccine candidate targeting different populations, ... -
Liposome mediated-CYP1A1 gene silencing nanomedicine prepared using lipid film-coated proliposomes as a potential treatment strategy of lung cancer.
Zhang, Mengtian; Wang, Qin; Wan, Ka-Wai; Ahmed, Waqar; Phoenix, David A; Zhang, Zhirong; Elrayess, Mohamed A; Elhissi, Abdelbary; Sun, Xun... more authors ... less authors ( Elsevier , 2019 , Article)The occurrence of lung cancer is linked with tobacco smoking, mainly through the generation of polycyclic aromatic hydrocarbons (PAHs). Elevated activity of cytochrome P4501A1 (CYP1A1) plays an important role in the metabolic ... -
Mediators of Impaired Adipogenesis in Obesity-Associated Insulin Resistance and T2DM
Al-Sulaiti, Haya; Dömling, Alexander S.; Elrayess, Mohamed A ( IntechOpen , 2019 , Book chapter)Obesity has become a global health issue due to its high prevalence and associated comorbidities including insulin resistance (IR) and type 2 diabetes mellitus (T2DM). Obesity is associated with the expansion of adipose ... -
Metabolic consequences of obesity on the hypercoagulable state of polycystic ovary syndrome.
Moin, Abu Saleh Md; Sathyapalan, Thozhukat; Diboun, Ilhame; Elrayess, Mohamed A; Butler, Alexandra E; Atkin, Stephen L... more authors ... less authors ( Nature Research , 2021 , Article)Polycystic ovary syndrome (PCOS) women have a hypercoagulable state; however, whether this is intrinsically due to PCOS or, alternatively, a consequence of its metabolic complications is unclear. We determined plasma ... -
Metabolic profiling of elite athletes with different cardiovascular demand
Al-Khelaifi, Fatima; Donati, Francesco; Botrè, Francesco; Latiff, Aishah; Abraham, David; Hingorani, Aroon; Georgakopoulos, Costas; Suhre, Karsten; Yousri, Noha A; Elrayess, Mohamed A... more authors ... less authors ( John Wiley & Sons Ltd , 2019 , Article)Intensive exercise of elite athletes can lead to physiological alterations in the cardiovascular system in response to increased stroke volume and blood pressure, known collectively as cardiovascular demand (CD). This study ... -
Metabolic profiling of pre-gestational and gestational diabetes mellitus identifies novel predictors of pre-term delivery.
Diboun, Ilhame; Ramanjaneya, Manjunath; Majeed, Yasser; Ahmed, Lina; Bashir, Mohammed; Butler, Alexandra E; Abou-Samra, Abdul Badi; Atkin, Stephen L; Mazloum, Nayef A; Elrayess, Mohamed A... more authors ... less authors ( BMC , 2020 , Article)Pregnant women with gestational diabetes mellitus (GDM) or type 2 diabetes mellitus (T2DM) are at increased risks of pre-term labor, hypertension and preeclampsia. In this study, metabolic profiling of blood samples collected ... -
Metabolic Signature of Leukocyte Telomere Length in Elite Male Soccer Players
Al-Muraikhy, Shamma; Sellami, Maha; Domling, Alexander S; Rizwana, Najeha; Agouni, Abdelali; Al-Khelaifi, Fatima; Donati, Francesco; Botre, Francesco; Diboun, Ilhame; Elrayess, Mohamed A... more authors ... less authors ( Frontiers Media , 2021 , Article)Biological aging is associated with changes in the metabolic pathways. Leukocyte telomere length (LTL) is a predictive marker of biological aging; however, the underlying metabolic pathways remain largely unknown. The aim ... -
Metabolic signature of obesity-associated insulin resistance and type 2 diabetes.
Al-Sulaiti, Haya; Diboun, Ilhame; Agha, Maha V; Mohamed, Fatima F S; Atkin, Stephen; Dömling, Alex S; Elrayess, Mohamed A; Mazloum, Nayef A... more authors ... less authors ( BMC , 2019 , Article)Obesity is associated with an increased risk of insulin resistance and type 2 diabetes mellitus (T2DM). However, some obese individuals maintain their insulin sensitivity and exhibit a lower risk of associated comorbidities. ... -
Metabolic Signatures of Type 2 Diabetes Mellitus and Hypertension in COVID-19 Patients With Different Disease Severity.
Elrayess, Mohamed A; Cyprian, Farhan S; Abdallah, Abdallah M; Emara, Mohamed M; Diboun, Ilhame; Anwardeen, Najeha; Schuchardt, Sven; Yassine, Hadi M... more authors ... less authors ( Frontiers Media , 2022 , Article)Increased COVID-19 disease severity is higher among patients with type 2 diabetes mellitus and hypertension. However, the metabolic pathways underlying this association are not fully characterized. This study aims to ... -
The Metabolic Switch of Physical Activity in Non-Obese Insulin Resistant Individuals.
Almuraikhy, Shamma; Anwardeen, Najeha; Doudin, Asmma; Sellami, Maha; Domling, Alexander; Agouni, Abdelali; Al Thani, Asmaa A; Elrayess, Mohamed A... more authors ... less authors ( MDPI , 2023 , Article)Healthy non-obese insulin resistant (IR) individuals are at higher risk of metabolic syndrome. The metabolic signature of the increased risk was previously determined. Physical activity can lower the risk of insulin ...