• Global pattern, trend, and cross-country inequality of early musculoskeletal disorders from 1990 to 2019, with projection from 2020 to 2050 

      Yingzhao, Jin; Guo, Cui; Abbasian, Mohammadreza; Abbasifard, Mitra; Abbott, J. Haxby; ... more authors ( Elsevier , 2024 , Article)
      BackgroundThis study aims to estimate the burden, trends, forecasts, and disparities of early musculoskeletal (MSK) disorders among individuals ages 15 to 39 years. MethodsThe global prevalence, years lived with disabilities ...
    • Global, regional, and national burden of diabetes from 1990 to 2021, with projections of prevalence to 2050: a systematic analysis for the Global Burden of Disease Study 2021 

      Kanyin Liane, Ong; Stafford, Lauryn K; McLaughlin, Susan A; Boyko, Edward J; Vollset, Stein Emil; ... more authors ( Elsevier , 2023 , Article)
      BackgroundDiabetes is one of the leading causes of death and disability worldwide, and affects people regardless of country, age group, or sex. Using the most recent evidentiary and analytical framework from the Global ...
    • Global, regional, and national burden of disorders affecting the nervous system, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021 

      Jaimie D, Steinmetz; Seeher, Katrin Maria; Schiess, Nicoline; Nichols, Emma; Cao, Bochen; ... more authors ( Elsevier , 2024 , Article)
      Background Disorders affecting the nervous system are diverse and include neurodevelopmental disorders, late-life neurodegeneration, and newly emergent conditions, such as cognitive impairment following COVID-19. Previous ...
    • Impact of bariatric surgery on circulating irisin levels: a systematic review and meta‑analysis 

      Jamialahamdi, Tannaz; Mirhadi, Elaheh; Almahmeed, Wael; Eid, Ali H.; Al-Rasadi, Khalid; ... more authors ( Springer Nature , 2024 , Article)
      This systematic review and meta-analysis evaluated changes in circulating irisin levels after bariatric surgery. A systematic search was performed across Embase, Scopus, PubMed, and Web of Science for this study. The ...
    • Inflammation and hypertension: Underlying mechanisms and emerging understandings 

      Aboukhater, Diana; Morad, Bassel; Nasrallah, Nadim; Nasser, Suzanne A.; Sahebkar, Amirhossein; ... more authors ( wiley online library , 2023 , Article Review)
      Hypertension remains a major contributor to cardiovascular disease (CVD), a leading cause of global death. One of the major insults that drive increased blood pressure is inflammation. While it is the body's defensive ...
    • Intermittent fasting favorably modulates adipokines and potentially attenuates atherosclerosis 

      Al Zein, Mohammad; Zein, Omar; Diab, Rawan; Dimachkie, Lina; Sahebkar, Amirhossein; ... more authors ( Elsevier Inc. , 2023 , Article)
      Adipose tissue is now recognized as an endocrine organ that secretes bioactive molecules called adipokines. These biomolecules regulate key physiological functions, including insulin sensitivity, energy metabolism, appetite ...
    • Measuring universal health coverage based on an index of effective coverage of health services in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019 

      Rafael, Lozano; Fullman, Nancy; Mumford, John Everett; Knight, Megan; Barthelemy, Celine M; ... more authors ( Elsevier , 2020 , Article)
      Background Achieving universal health coverage (UHC) involves all people receiving the health services they need, of high quality, without experiencing financial hardship. Making progress towards UHC is a policy priority ...
    • MicroRNA-mediated regulation of LDL receptor: biological and pharmacological implications. 

      Keshavarz, Reyhaneh; Reiner, Željko; Zengin, Gokhan; Eid, Ali H; Sahebkar, Amirhossein ( Europe PM , 2023 , Article)
      One of the main causes of atherosclerosis is a disruption in cellular cholesterol hemostasis. The low-density lipoprotein receptor (LDLR) is an important factor in maintaining cholesterol homeostasis by the receptor-mediated ...
    • Paradoxical effects of statins on endothelial and cancer cells: the impact of concentrations 

      Ahmadi, Yasin; Fard, Javad Khalili; Ghafoor, Dlzar; Eid, Ali H.; Sahebkar, Amirhossein ( Springer Nature , 2023 , Article)
      In addition to their lipid-lowering functions, statins elicit additional pleiotropic effects on apoptosis, angiogenesis, inflammation, senescence, and oxidative stress. Many of these effects have been reported in cancerous ...
    • The pharmaco-epigenetics of hypertension: a focus on microRNA 

      Yaacoub, Serge; Boudaka, Ammar; AlKhatib, Ali; Pintus, Gianfranco; Sahebkar, Amirhossein; ... more authors ( Springer Nature , 2024 , Article)
      Hypertension is a major harbinger of cardiovascular morbidity and mortality. It predisposes to higher rates of myocardial infarction, chronic kidney failure, stroke, and heart failure than most other risk factors. By 2025, ...
    • Pleiotropic properties of statins via angiogenesis modulation in cardiovascular disease 

      Fatemeh, Zahedipour; Butler, Alexandra E.; Eid, Ali H.; Sahebkar, Amirhossein ( Elsevier , 2022 , Article)
      Inhibition of hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase by statins is affected by inhibiting the active site of the enzyme in a competitive manner. Statins reduce plasma cholesterol by inhibiting its de novo ...
    • Therapeutic effects of statins on osteoarthritis: A review 

      Saberianpour, Shirin; Abolbashari, Samaneh; Modaghegh, Mohamad H.S.; Karimian, Maryam S.; Eid, Ali H.; ... more authors ( Wiley , 2022 , Article Review)
      Osteoarthritis (OA) is a progressive joint disease. The etiology of OA is considered to be multifactorial. Currently, there is no definitive treatment for OA, and the existing treatments are not very effective. ...