Browsing by Author "Kobeissy, Firas"

Now showing items 21-30 of 30

    • Novel therapeutic strategies for spinal osteosarcomas 

      M. Akhtar, Anwar; El-Baba, Chirine; Elnaggar, Muhammed H.; Elkholy, Yasmeen O.; Mottawea, Mohamed; ... more authors ( Elsevier , 2020 , Article Review)
      At the dawn of the third millennium, cancer has become the bane of twenty-first century man, and remains a predominant public health burden, affecting welfare and life expectancy globally. Spinal osteogenic sarcoma, a ...

    • Origanum syriacum L. Attenuates the Malignant Phenotype of MDA-MB231 Breast Cancer Cells 

      AlKahlout, Amal; Fardoun, Manal; Mesmar, Joelle; Abdallah, Rola; Badran, Adnan; ... more authors ( Frontiers Media , 2022 , Article)
      Breast cancer is the leading cause of cancer-related deaths among women. Among breast cancer types, triple negative breast cancer (TNBC) is the most aggressive, and is resistant to hormonal and chemotherapeutic treatments. ...

    • Phytochemicals as Micronutrients: What Is their Therapeutic Promise in the Management of Alzheimer’s Disease? 

      Reslan, Mohammad Amine; Issa, Hawraa; Al-Haj, Nadine; Ibeh, Stanley; Yehya, Yara; ... more authors ( Springer Singapore , 2022 , Book chapter)
      Alzheimer’s disease (AD) is a debilitating neurodegenerative disease with devastating outcomes to patients and exhaustive burdens to healthcare systems. Alzheimer’s disease has always been the focus of extensive research ...

    • Phytochemicals as Micronutrients: What Is their Therapeutic Promise in the Management of Traumatic Brain Injury? 

      Al-Haj, Nadine; Issa, Hawraa; El Zein, Ola; Ibeh, Stanley; Reslan, Mohammad Amine; ... more authors ( Springer Singapore , 2022 , Book chapter)
      Traumatic brain injury (TBI) is one of the key causes of deaths and disabilities worldwide. TBI progresses in two phases. The primary phase of injury is the direct result of the physical damage caused by the external force ...

    • Retinoids and Reactive Oxygen Species in Cancer Cell Death and Therapeutics 

      El-Baba, Chirine; Eid, Ali H.; Shaito, Abdallah; Kobeissy, Firas; Darwiche, Nadine ( Springer Nature , 2022 , Book chapter)
      Retinoids are a large family of structurally related natural and synthetic molecules that exhibit a variety of effects in embryogenesis and adult life. The parent compound of retinoids is vitamin A which was first discovered ...

    • SARS-CoV-2 involvement in central nervous system tissue damage 

      Haidar, Muhammad Ali; Shakkour, Zaynab; Reslan, Mohammad Amine; Al-Haj, Nadine; Chamoun, Perla; ... more authors ( Wolters Kluwer , 2022 , Article Review)
      As the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to spread globally, it became evident that the SARS-CoV-2 virus infects multiple organs including the brain. Several clinical studies revealed ...

    • The mitochondria: A target of polyphenols in the treatment of diabetic cardiomyopathy 

      Bhagani, Humna; Nasser, Suzanne A.; Dakroub, Ali; El-Yazbi, Ahmed F.; Eid, Assaad A.; ... more authors ( MDPI , 2020 , Article)
      Diabetic cardiomyopathy (DCM) is a constellation of symptoms consisting of ventricular dysfunction and cardiomyocyte disarray in the presence of diabetes. The exact cause of this type of cardiomyopathy is still unknown; ...

    • Therapeutic potential of flavonoids in cancer: ROS-mediated mechanisms 

      Hasan, Slika; Mansour, Hadi; Wehbe, Nadine; Nasser, Suzanne A.; Iratni, Rabah; ... more authors ( Elsevier , 2022 , Article)
      Cancer is a leading cause of morbidity and mortality around the globe. Reactive oxygen species (ROS) play contradicting roles in cancer incidence and progression. Antioxidants have attracted attention as emerging therapeutic ...

    • Traumatic Brain Injury Can Affect Emotions and Behaviors 

      Shakkour, Zaynab; Habashy, Karl John; Haidar, Muhammad Ali; Nasrallah, Leila; Tabet, Maha; ... more authors ( Frontiers Media , 2023 , Article)
      Proper brain functioning is responsible for our feelings, behavior, and thinking. However, an injury to the brain can disrupt brain function, which can affect our emotions and behaviors. A traumatic brain injury (TBI) can ...

    • Visfatin : An emerging adipocytokine bridging the gap in the evolution of cardiovascular diseases 

      Dakroub, Ali; Nasser, Suzanne A; Kobeissy, Firas; Yassine, Hadi M; Orekhov, Alexander; ... more authors ( Wiley , 2021 , Article)
      Visfatin/nicotinamide phosphoribosyltransferase (NAMPT) is an adipokine expressed predominately in visceral fat tissues. High circulating levels of visfatin/NAMPT have been implicated in vascular remodeling, vascular ...