Browsing by Author "Elrayess, Mohamed A."
Now showing items 41-60 of 62
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Metabolomic Profiling of Pregnancies With Polycystic Ovary Syndrome Identifies a Unique Metabolic Signature and Potential Predictive Biomarkers of Low Birth Weight
Diboun, Ilhame; Ramanjaneya, Manjunath; Ahmed, Lina; Bashir, Mohammed; Butler, Alexandra E; Albagha, Omar; Abou-Samra, Abdul Badi; Atkin, Stephen L; Mazloum, Nayef A; Elrayess, Mohamed A... more authors ... less authors ( Frontiers Media , 2021 , Article)Polycystic ovary syndrome (PCOS) is a complex syndrome with clinical features of an endocrine/metabolic disorder. Various metabolites show significant association with PCOS; however, studies comparing the metabolic profile ... -
Metabolomics and doping analysis: promises and pitfalls.
Botrè, Francesco; Georgakopoulos, Costas; Elrayess, Mohamed A ( Future Science , 2020 , Article)This brief commentary presents an overview of the potential utility of metabolomics-based approaches in doping analysis, with particular emphasis on areas where the current analytical procedures would most benefit from ... -
Metabolomics of lean/overweight insulin resistant females reveals alterations in steroids and fatty acids.
Diboun, Ilhame; Al-Mansoori, Layla; Al-Jaber, Hend; Albagha, Omar; Elrayess, Mohamed A ( Endocrine Society , 2020 , Article)The global diabetes epidemic is largely attributed to obesity-triggered metabolic syndrome. However, the impact of insulin resistance (IR) prior to obesity on the high prevalence of diabetes and the molecular mediators ... -
Metabolomics Profiling of Vitamin D Status in Relation to Dyslipidemia
Mousa, Hanaa; Elrayess, Mohamed A.; Diboun, Ilhame; Jackson, Simon K.; Zughaier, Susu M. ( MDPI , 2022 , Article)Vitamin D deficiency is a global disorder associated with several chronic illnesses including dyslipidemia and metabolic syndrome. The impact of this association with both dyslipidemia and vitamin D deficiency on metabolomics ... -
Metformin increases 3-hydroxy medium chain fatty acids in patients with type 2 diabetes: a cross-sectional pharmacometabolomic study
Naja, Khaled; Anwardeen, Najeha; Malki, Ahmed M.; Elrayess, Mohamed A. ( Frontiers Media SA , 2024 , Article)Background: Metformin is a drug with a long history of providing benefits in diabetes management and beyond. The mechanisms of action of metformin are complex, and continue to be actively debated and investigated. The aim ... -
Molecular Big Data in Sports Sciences: State-of-Art and Future Prospects of OMICS-Based Sports Sciences.
Sellami, Maha; Elrayess, Mohamed A; Puce, Luca; Bragazzi, Nicola Luigi ( Frontiers Media , 2022 , Article)Together with environment and experience (that is to say, diet and training), the biological and genetic make-up of an athlete plays a major role in exercise physiology. Sports genomics has shown, indeed, that some DNA ... -
Molecular regulators of exercise-mediated insulin sensitivity in non-obese individuals
Almuraikhy, Shamma; Doudin, Asmaa; Domling, Alexander; Althani, Asmaa Ali J.F.; Elrayess, Mohamed A. ( John Wiley and Sons Inc , 2023 , Article)Insulin resistance is a significant contributor to the development of type 2 diabetes (T2D) and is associated with obesity, physical inactivity, and low maximal oxygen uptake. While intense and prolonged exercise may have ... -
Predictive Biomarkers of Intensive Care Unit and Mechanical Ventilation Duration in Critically-Ill Coronavirus Disease 2019 Patients.
Taleb, Sara; Yassine, Hadi M; Benslimane, Fatiha M; Smatti, Maria K; Schuchardt, Sven; Albagha, Omar; Al-Thani, Asmaa A; Ait Hssain, Ali; Diboun, Ilhame; Elrayess, Mohamed A... more authors ... less authors ( Frontiers Media , 2021 , Article)Detection of early metabolic changes in critically-ill coronavirus disease 2019 (COVID-19) patients under invasive mechanical ventilation (IMV) at the intensive care unit (ICU) could predict recovery patterns and help in ... -
Prevalence and Predictors of Insulin Resistance in Non-Obese Healthy Young Females in Qatar
Elrayess, Mohamed A.; Rizk, Nasser M.; Fadel, Amina S.; Kerkadi, Abdelhamid ( MDPI , 2020 , Article)The state of Qatar suffers from diabetes epidemic due to obesity-associated metabolic syndrome. However, the prevalence of insulin resistance prior to obesity, which could play an important role in the high prevalence of ... -
Profiling the Oral Microbiome and Plasma Biochemistry of Obese Hyperglycemic Subjects in Qatar
Sohail, Muhammad U; Elrayess, Mohamed A; Al Thani, A A; Al-Asmakh, M; Yassine, Hadi M ( MDPI , 2019 , Article)The present study is designed to compare demographic characteristics, plasma biochemistry, and the oral microbiome in obese (N = 37) and lean control (N = 36) subjects enrolled at Qatar Biobank, Qatar. Plasma hormones, ... -
Protein tyrosine phosphatase 1B inhibition improves endoplasmic reticulum stress-impaired endothelial cell angiogenic response: A critical role for cell survival
ABDELSALAM, SHAHENDA S.; PASHA, MAZHAR; EL-GAMAL, HEBA; HASAN, MARAM; ELRAYESS, MOHAMED A.; ZEIDAN, ASAD; KORASHY, HESHAM M.; AGOUNI, ABDELALI... more authors ... less authors ( Spandidos publications , 2021 , Article)Endoplasmic reticulum (ER) stress contributes to endothelial dysfunction, which is the initial step in atherogenesis. Blockade of protein tyrosine phosphatase (PTP)1B, a negative regulator of insulin receptors that is ... -
The Relationship between Changes in MYBPC3 Single-Nucleotide Polymorphism-Associated Metabolites and Elite Athletes’ Adaptive Cardiac Function
Riguene, Emna; Theodoridou, Maria; Barrak, Laila; Elrayess, Mohamed A.; Nomikos, Michail ( MDPI , 2023 , Article Review)Athletic performance is a multifactorial trait influenced by a complex interaction of environmental and genetic factors. Over the last decades, understanding and improving elite athletes’ endurance and performance has ... -
The retrospective study of the metabolic patterns of BCG-vaccination in type-2 diabetic individuals in COVID-19 infection
Anwardeen, Najeha R.; Cyprian, Farhan S.; Yassine, Hadi M.; Al-Thani, Asmaa A.; Abdallah, Abdallah M.; Emara, Mohamed M.; Elrayess, Mohamed A.... more authors ... less authors ( Frontiers Media , 2023 , Article)Background: The cross-protective nature of Bacillus Calmette-Guerin (BCG) vaccine against SARS-CoV-2 virus was previously suggested, however its effect in COVID-19 patients with type 2 diabetes (T2D) and the underlying ... -
Role of Inflammatory Cytokines, Growth Factors and Adipokines in Adipogenesis and Insulin Resistance
Al-Mansoori, Layla; Al-Jaber, Hend; Prince, Mohammad Shoaib; Elrayess, Mohamed A. ( Springer , 2021 , Article Review)Obesity, manifested by increased adiposity, represents a main cause of morbidity in the developed countries, causing increased risk of insulin resistance and type 2 diabetes mellitus. Recruitment of macrophages and activation ... -
Sestrin2 as a Protective Shield against Cardiovascular Disease
Zahid, Muhammad Ammar; Abdelsalam, Shahenda Salaheldin; Raïq, Hicham; Parray, Aijaz; Korashy, Hesham Mohamed; Zeidan, Asad; Elrayess, Mohamed A.; Agouni, Abdelali... more authors ... less authors ( Multidisciplinary Digital Publishing Institute (MDPI) , 2023 , Article)A timely and adequate response to stress is inherently present in each cell and is important for maintaining the proper functioning of the cell in changing intracellular and extracellular environments. Disruptions in the ... -
Sestrin2 suppression aggravates oxidative stress and apoptosis in endothelial cells subjected to pharmacologically induced endoplasmic reticulum stress
Fatima, Munazza T; Hasan, Maram; Abdelsalam, Shahenda S; Sivaraman, Siveen K; El-Gamal, Heba; Zahid, Muhammad A; Elrayess, Mohamed A; Korashy, Hesham M; Zeidan, Asad; Parray, Aijaz S; Agouni, Abdelali... more authors ... less authors ( Elsevier , 2021 , Article)Endoplasmic reticulum (ER) stress is an inflammatory response that contributes to endothelial dysfunction, a hallmark of cardiovascular diseases, in close interplay with oxidative stress. Recently, Sestrin2 (SESN2) emerged ... -
Signal transducer and activator of transcription 3 (Stat3) suppresses stat1/interferon signaling pathway and inflammation in senescent preadipocytes
Madani, Aisha Y.; Majeed, Yasser; Abdesselem, Houari B.; Agha, Maha V.; Vakayil, Muneera; Al Sukhun, Nour K.; Halabi, Najeeb M.; Kumar, Pankaj; Hayat, Shahina; Elrayess, Mohamed A.; Rafii, Arash; Suhre, Karsten; Mazloum, Nayef A.... more authors ... less authors ( MDPI , 2021 , Article)© 2021 by the authors. Licensee MDPI, Basel, Switzerland. Obesity promotes premature aging and dysfunction of white adipose tissue (WAT) through the accumulation of cellular senescence. The senescent cells burden in WAT ... -
Signal Transducer and Activator of Transcription 3 (STAT3) Suppresses STAT1/Interferon Signaling Pathway and Inflammation in Senescent Preadipocytes.
Madani, Aisha Y; Majeed, Yasser; Abdesselem, Houari B; Agha, Maha V; Vakayil, Muneera; Sukhun, Nour K Al; Halabi, Najeeb M; Kumar, Pankaj; Hayat, Shahina; Elrayess, Mohamed A; Rafii, Arash; Suhre, Karsten; Mazloum, Nayef A... more authors ... less authors ( MDPI , 2021 , Article)Obesity promotes premature aging and dysfunction of white adipose tissue (WAT) through the accumulation of cellular senescence. The senescent cells burden in WAT has been linked to inflammation, insulin-resistance (IR), ... -
SIRT1 promotes lipid metabolism and mitochondrial biogenesis in adipocytes and coordinates adipogenesis by targeting key enzymatic pathways.
Majeed, Yasser; Halabi, Najeeb; Madani, Aisha Y; Engelke, Rudolf; Bhagwat, Aditya M; Abdesselem, Houari; Agha, Maha V; Vakayil, Muneera; Courjaret, Raphael; Goswami, Neha; Hamidane, Hisham Ben; Elrayess, Mohamed A; Rafii, Arash; Graumann, Johannes; Schmidt, Frank; Mazloum, Nayef A... more authors ... less authors ( Nature Research , 2021 , Article)The NAD-dependent deacetylase SIRT1 controls key metabolic functions by deacetylating target proteins and strategies that promote SIRT1 function such as SIRT1 overexpression or NAD boosters alleviate metabolic complications. ... -
Soluble ACE2 and Angiotensin II levels Modulated in Hypertensive COVID-19 Patients treated with different Antihypertension Drugs
Yalcin, Huseyin C.; Elrayess, Mohamed A; Al-Jighefee, Hadeel T; Al-Ruweidi, Mahmoud Khatib A. A.; Almuraikhy, Shamma; Yassine, Hadi M.... more authors ... less authors ( Qatar University Press , 2021 , Poster)Hypertension is a major risk factor and common comorbidity among severe Coronavirus Disease 2019 (COVID-19) patients. Prominent antihypertensive drugs, such as angiotensin-converting-enzyme inhibitors (ACEi) and angiotensin ...