• Animal Health Monitoring Program (AHMP) of LARC 

      Shanmugakonar, Muralitharan; Abujassoum, Hamda; Khan, Imran; Al Naemi, Hamda (2017 , Poster)
      Animal health monitoring is important to maintain the health of the animals used for research purpose. Maintaining healthy research animals is the prime requisite for best research outcomes. Health monitoring is performed ...
    • Cardiac Myosin Binding Protein-C in Sprague Dawley (SD) Rats exposed to Sub-Chronic oral dose of Cadmium Chloride 

      Al-Borshaid, Enjoud Khalifa; Varadharajan, Kavitha; Shanmugakonar, Muralitharan; Al-Naemi, Hamda ( Qatar University Press , 2021 , Poster)
      Cadmium is one of the major environmental pollutants associated with an increment in industrial and urbanization activities. It has health consequences when it reaches the human diet through the soil, water, and plant. ...
    • Diagnostic Microbiology Laboratory Monitoring of LARC 

      Khan, Imran; Shanmugakonar, Muralitharan; Aboujassoum, Hamda; Al Naemi, Hamda (2017 , Poster)
      Microbial free environment of a research facility is critical to maintain animal health. Establishing Microbiological Monitoring Program is mandatory to assure the quality of the system. Microbiological monitoring involves ...
    • Effect of CARMA 2sh gene in Mouse embryonic stem (ES) cells 

      Shanmugakonar, Muralitharan; Varadharajan, Kavitha; Vito, Pasquale (2017 , Poster)
      CARMA2 belongs to the CARMA family of proteins. They are involved in the regulation and activation of NF-κB that have a central role in the control of immune and inflammatory response, and cell survival and proliferation. ...
    • Environmental Health Monitoring Program (EHMP) of LARC 

      Shanmugakonar, Muralitharan; Abujassoum, Hamda; Khan, Imran; Al Naemi, Hamda (2017 , Poster)
      Routine environmental monitoring is the prime necessity to maintain a Specific Pathogen Free (SPF) facility. Monitoring the animals & its environment is important to control the contamination and outbreak of disease. ...
    • Expression of active and inactive forms of CIK and CARMA 2sh proteins in Normal Human Epidermal Keratinocytes (NHEK) 

      Shanmugakonar, Muralitharan; Varadharajan, Kavitha; Vito, Pasquale (2016 , Poster)
      Psoriasis is a debilitating skin disease affecting approximately 23% of human population. The disease is considered to have key genetic underpinning and genome wide association studies and meta analysis have identified ...
    • Functional In Vivo Imaging of Tumors. 

      Haris, Mohammad; Nisar, Sabah; Hashem, Sheema; Bhat, Ajaz A; Yadav, Santosh; ... more authors ( Springer , 2020 , Book chapter)
      Noninvasive imaging of functional and molecular changes in cancer has become an indispensable tool for studying cancer in vivo. Targeting the functional and molecular changes in cancer imaging provides a platform for the ...
    • Gut Microbiota and Health: Understanding the Role of Diet 

      Alasmar, Reem Moath; Varadharajan, Kavitha; Shanmugakonar, Muralitharan; Al-Naemi, Hamda A. ( Scientific Research Publishing , 2019 , Article Review)
      Microbiome now is considered as an organ within our system to regulate metabolism, cellular immune response and eventually maintain the health. Gut microbiota has been studied extensively in the recent past due to the ...
    • Gut Microbiota and Health: Understanding the Role of Diet 

      Alasmar, Reem; Varadharajan, Kavitha; Shanmugakonar, Muralitharan; Al-Naemi, Hamda ( Qatar University Press , 2020 , Poster)
      Gut microbiota plays a major role in regulating the host metabolism and immune system. However, the structure of microbiome population is altered constantly by diverse factors including diet and environment. In particular, ...
    • Gut Microbiota Dysbiosis and Their Impact on Biochemical and Inflammatory Profiles in Cafeteria Diet Fed Sprague Dawley Rats 

      Alasmar, Reem Moath; Varadharajan, Kavitha; Shanmugakonar, Muralitharan; Al-Naemi, Hamda A. ( Scientific Research Publishing , 2019 , Article)
      Gut microbiota plays a major role in regulating the host metabolism and immune system. However, the structure of microbiome population is altered constantly by diverse factors including diet and environment. In particular, ...
    • Gut Microbiota Dysbiosis in Cafeteria Diet Fed Sprague Dawley Rats 

      Varadharajan, Kavitha; Shanmugakonar, Muralitharan; Das, Sandra Concepcion; Al-Naemi, Hamda A. ( Scientific Research Publishing , 2018 , Article)
      Diet plays a major role in the body physiology and metabolism. The quantity, nature and stability of the macronutrients present in the diet have a major impact on the composition of gut microbiota. Gut microbiota plays a ...
    • In Vitro Analysis of Psoriasis Linked CARMA2sh Gene in Keratinocytes and Mouse Embryonic Stem Cells towards Developing a Murine Transgenic Model 

      Varadharajan, Kavitha; Shanmugakonar, Muralitharan; Vito, Pasquale ( American Association For Laboratory Animal Science , 2017 , Poster)
      Psoriasis is a debilitating skin disease affecting approximately 23% of human population. Genome-wide association studies have identified more than 40 susceptibility loci for psoriasis. CARMA2 proteins play a major role ...
    • LABORATORY ANIMAL RESEARCH CENTRE (LARC) “A SPECIFIC PATHOGEN FREE RODENT FACILITY” - COVID – 19 PANDEMIC RESPONSE PLAN 

      Shanmugakonar, Muralitharan; Govindharajan, Vijay Kanth; Varadharajan, Kavitha; Al-Naemi, Hamda ( Qatar University Press , 2020 , Poster)
      Laboratory Animal Research Centre (LARC) has developed an early emergency operational plan for COVID-19 pandemic situation. Biosafety and biosecurity measures were planned and implemented ahead of time to check the functional ...
    • Quantification of bioburden in LARC'S Vivarium 

      Khan, Imran; Shanmugakonar, Muralitharan; Al-Naemi, Hamda ( Qatar University Press , 2020 , Poster)
      Sanitization of cleanrooms in animal facilities is important as it ensures the level of contamination by different means including personnel activities and failures of HVAC system.Cleanrooms are highly controlled to provide ...
    • RAS-mediated oncogenic signaling pathways in human malignancies 

      Khan, Abdul Q.; Kuttikrishnan, Shilpa; Kodappully S., Siveen; Kirti S., Prabhu; Shanmugakonar, Muralitharan; ... more authors ( Elsevier , 2018 , Article Review)
      Abnormally activated RAS proteins are the main oncogenic driver that governs the functioning of major signaling pathways involved in the initiation and development of human malignancies. Mutations in RAS genes and or its ...
    • Tight Junction Proteins and Signaling Pathways in Cancer and Inflammation: A Functional Crosstalk. 

      Bhat, Ajaz A; Uppada, Srijayaprakash; Achkar, Iman W; Hashem, Sheema; Yadav, Santosh K; ... more authors ( Frontiers Media , 2019 , Article)
      The ability of epithelial cells to organize through cell-cell adhesion into a functioning epithelium serves the purpose of a tight epithelial protective barrier. Contacts between adjacent cells are made up of tight junctions ...