• Abnormal brain structure and behavior in MyD88-deficient mice. 

      Schroeder, Patricia; Rivalan, Marion; Zaqout, Sami; Krüger, Christina; Schüler, Jutta; ... more authors ( Elsevier , 2021 , Article)
      While the original protein Toll in Drosophila melanogaster regulates both host defense and morphogenesis, the role of its ortholog Toll-like receptors (TLRs), the interleukin 1 receptor (IL-1R) family, and the associated ...
    • Congenital microcephaly-linked CDK5RAP2 affects eye development 

      Zaqout, Sami; Ravindran, Ethiraj; Stoltenburg-Didinger, Gisela; Kaindl, Angela M ( Wiley , 2020 , Article)
      Biallelic mutations in the cyclin-dependent kinase 5 regulatory subunit-associated protein 2 gene CDK5RAP2 cause autosomal recessive primary microcephaly type 3 (MCPH3). MCPH is characterized by intellectual disability and ...
    • A Golgi study of neurons in the camel cerebellum (Camelus dromedarius) 

      Al-Hussain, Saleh M.; Yousuf, Mustafa S.; Hani, Ayat Bani; Zaqout, Sami; Djouhri, Laiche; ... more authors ( Wiley , 2021 , Article)
      Neurons in the cerebellar cortex of camels were studied using modified Golgi impregnation methods. Neurons were classified according to their position, morphology of their soma, density and distribution of dendrites, and ...
    • Homozygous mutation in MCM7 causes autosomal recessive primary microcephaly and intellectual disability 

      Ravindran, Ethiraj; Gutierrez de Velazco, Cynthia; Ghazanfar, Ali; Kraemer, Nadine; Zaqout, Sami; ... more authors ( BMJ Publishing Group , 2021 , Article)
      Minichromosomal maintenance (MCM) complex components 2, 4, 5 and 6 have been linked to human disease with phenotypes including microcephaly and intellectual disability. The MCM complex has DNA helicase activity and is ...
    • Immunofluorescence Staining of Paraffin Sections Step by Step. 

      Zaqout, Sami; Becker, Lena-Luise; Kaindl, Angela M ( Frontiers Media , 2020 , Article)
      Immunofluorescence staining is the most frequently applied technique to detect and visualize various molecules in biological samples. Many protocols can be found in the literature and the websites of commercial antibody ...
    • The murine ortholog of Kaufman oculocerebrofacial syndrome protein Ube3b regulates synapse number by ubiquitinating Ppp3cc. 

      Ambrozkiewicz, Mateusz C; Borisova, Ekaterina; Schwark, Manuela; Ripamonti, Silvia; Schaub, Theres; ... more authors ( Springer Nature , 2020 , Article)
      Kaufman oculocerebrofacial syndrome (KOS) is a severe autosomal recessive disorder characterized by intellectual disability, developmental delays, microcephaly, and characteristic dysmorphisms. Biallelic mutations of UBE3B, ...
    • Neuronal Cell Types in the Anterior Ventral Thalamic Nucleus of the Camel. 

      Al-Hussain, Saleh M; Albostanji, Shaden A; Mustafa, Ayman G; Zaqout, Sami ( Wiley , 2021 , Article)
      The anterior ventral nucleus neurons in of the camel brain were morphologically studied by Golgi impregnation method. Two neuronal types of were found in the camel anterior ventral thalamic nucleus, namely, Golgi-type I ...
    • Role of Cdk5rap2 in neocortical inhibition and excitation balance 

      Zaqout, Sami; Becker, Lena-Luise; Mustafa, Ayman; Kramer, Nadine; Strauss, Ulf; ... more authors ( Qatar University Press , 2020 , Poster)
      Autosomal recessive primary microcephaly type 3 (MCPH3) is characterized by congenital microcephaly and intellectual disability. Further features include hyperactivity and seizures. The disease is caused by biallelic ...